Research Centers in Trauma, Burn, and Peri-Operative Injury (P50)

Research Centers in Trauma, Burn, and Peri-Operative Injury (P50) is sponsored by National Institutes of Health (NIH) - NIGMS. This program encourages grant applications from institutions/organizations for Research Centers in Trauma, Burn, and Peri-operative Injury.

Expired PAR-09-048: Research Centers in Trauma, Burn, and Peri-Operative Injury (P50) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Institutes of Health (NIH), ( http://www.

nih. gov/ ) Components of Participating Organizations Institute of General Medical Sciences (NIGMS), ( http://www. nigms.

nih. gov/ ) Centers in Trauma, Burn, and Peri-Operative Injury (P50) Update: The following update relating to this announcement has been issued: January 10, 2012 - See Notice NOT-GM-11-118. The purpose of this Notice is to inform interested applicants from eligible institutions that NIGMS is extending the expiration date.

November 16, 2009 - This FOA has been updated to reflect the new requirements from NIH’s Enhancing Peer Review Initiative. The new requirements are effective for submissions intended for due dates January 25, 2010 and beyond. If submitting an application intended for a due date of January 25, 2010 and beyond, follow the guidance below and be sure to use the 06/2009 version of the PHS 398 application forms and instructions.

If applying for a due date before January 25, 2010, follow the guidance in the archived version of this FOA and be sure to use the 11/2007 version of the PHS 398 application forms and instructions. of the Department of Health and Human Services' implementation of e-Government the NIH will gradually transition each research grant mechanism to electronic submission through Grants.

gov and the use of the SF 424 Research and Related (R&R) forms. For more information and an initial timeline, see http://grants. nih.

gov/grants/guide/notice-files/NOT-OD-06-035. html . NIH will announce each grant mechanism change in the NIH Guide to Grants and Contracts ( http://grants.

nih. gov/grants/guide/index. html ).

Program Announcement (PA) Number: PAR-09-048 Catalog of Federal Domestic Receipt Date(s): Letters of intent should arrive at NIGMS at least 30 days prior to the intended submission date. http://grants1. nih.

gov/grants/funding/submissionschedule. htm Application Submission Dates(s): Standard dates apply, please see http://grants1. nih.

gov/grants/funding/submissionschedule. htm Peer Review Date(s): Standard dates apply, please see http://grants1. nih.

gov/grants/funding/submissionschedule. htm#reviewandaward Council Review Date(s): Standard dates apply, please see http://grants1. nih.

gov/grants/funding/submissionschedule. htm#reviewandaward Earliest Anticipated Start Date: Standard dates apply, please see http://grants1. nih.

gov/grants/funding/submissionschedule. htm#reviewandaward Information To Be Available Date (Url Activation Date): N/A Expiration Date: (Extended to May 7, 2012 per NOT-GM-11-118 ), Original Date January Purpose .

This FOA issued by NIGMS, National Institutes of Health, encourages grant applications from institutions/ organizations for Research Centers in Trauma, Burn, and Peri-operative Injury (RCTBPI) program meant to provide support to 1) Improve understanding at all levels of the biological processes invoked after traumatic or burn injury, or in critically ill patients, including molecular and cellular, physiological, and multilevel integration of homeostatic loss and recovery; 2) Foster translational research, bringing basic scientific observations and principles into the clinical arena and using clinical observations to generate or validate mechanistic hypotheses; and 3) Foster interactions and communications within institutions and throughout the trauma community.

RCTBPI applications may include interventional studies if and only if there is connection, harmonization and synergy with the biological and physiological processes under investigation. An application that only proposes an interventional clinical trial would not be appropriate for this funding mechanism. Mechanism of Support.

This FOA will utilize P50 Research Center grant mechanism. Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Budget and Project Period. The project period may not exceed 5 years.

For this funding opportunity, budgets up to $7 million direct costs (exclusive of subcontractual facilities and administrative costs) for the entire 5 year period may be requested. Requests for large equipment necessary for the proposed research may be included in excess of this cap. An additional $250,000 direct cost per year may be requested specifically to support a Human Subjects Core as Eligible Institutions/Organizations.

Institutions/organizations listed in Section III, 1. A. are Eligible Project Directors/Principal Investigators with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. Only one PD/PI (i.e., no multiple PDs/PIs) may be designated on the application.

Number of Applications. Applicants may submit more than one application, provided that each application is scientifically distinct. Resubmissions.

Resubmission applications will be accepted. Such application must include an Introduction addressing the previous peer review critique (Summary Statement). See new NIH policy on resubmission (amended) applications ( NOT-OD-09-003 , NOT-OD-09-016 ).

Renewals. Applicants may submit a See Section IV. 1 for application All applications, including resubmission, revision and renewal, submitted for due dates January 25, 2010 and beyond, must utilize the current forms and instructions.

Impaired. Telecommunications for the hearing impaired are available at: TTY 301-451-5936. Part II Full Text of Announcement Section I.

Funding Opportunity Section II. Award Information 2. Cost Sharing or Matching 3.

Other - Special Eligibility Criteria IV. Application and Submission Information 1. Address to Request Application Information 2.

Content and Form of Application Submission 3. Submission Dates and Times A. Receipt and Review and B.

Sending an Application to C. Application Processing 4. Intergovernmental Review 6.

Other Submission Requirements and Information V. Application Review Information 2. Review and Selection Process A.

Additional Review Criteria B. Additional Review Considerations C. Resource Sharing Plan(s) Anticipated Announcement and Award Dates VI.

Award Administration Information 2. Administrative and National Policy Requirements 1. Scientific/Research Contact(s) 2.

Peer Review Contact(s) 3. Financial/ Grants Management Contact(s) VIII. Other Information - Required Federal Citations - Full Text of Announcement Section I.

Funding Opportunity Description The purpose of this FOA is to re-announce the National Institute of General Medical Sciences (NIGMS) "Research Centers in Trauma, Burn, and Peri-operative Injury program (RCTBPI). This FOA was originally issued as PAR-02-092. Both new and competing renewal applications will be accepted under this FOA.

The overall mission of the RCTBPI program is to foster hypothesis-based and translational research around a theme related to the human physiological response to injury and/or processes of acute/critical illness.

Specifically, these research centers are multi-disciplinary efforts that employ state-of-the-art technology and procedures to further the goal of understanding and better controlling the bodys response to the acute illness as is invoked by severe trauma or burn injury.

Relevant research could cover the immediate post-trauma period through ultimate resolution and is inclusive of conditions and complications commonly referred to as critical illness such as systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction syndrome (MODS) as well as the process through which wounds caused by injury are repaired and/or healed.

A RCTBPI application must feature collaborations and team approaches that would otherwise not be established, including individuals from multiple medical and scientific fields.

NIGMS expects that these collaborations be central to the RCTBPI, elevating a successful program beyond a collection of independent R01-type projects, meaning that there must be demonstrable evidence of significant value-added to grouping the research efforts together in a unified effort beyond a simple economy of resources.

A vital foundation for all RCTBPI within this program is that an emphasis must be placed on translational research. Appropriate RCTBPIs will adhere to the vision promoted as part of are increasingly aware that this bench-to-bedside approach to translational research is really a two-way street.

Basic scientists provide clinicians with new tools for use in patients and for assessment of their impact, and clinical researchers make novel observations about the nature and progression of disease that often stimulate basic investigations. programs must focus on what is now considered to be T1 translational research.

In light of the requirement for two-way communication between laboratory/clinical science and the bedside, it is expected that the successful centers will include research on human subjects, and most likely be patient-oriented. The entire research effort need not be solely based on human studies however, and a mix of in vitro or experimental model systems may be appropriate given the overall theme of the center.

Applications should propose some human and/or patient oriented research beyond creation and maintenance of a database containing clinical and/or biological/physiological information. Discovery-based/high-throughput studies may be proposed as an integral part but not the sole purpose of the RCTBPI application.

include interventional studies, or may in fact be based around trials if and only if there are complementary studies proposed that will further the understanding of the fundamental biological and physiological mechanisms underlying the human response to injury or acute critical illness. Accordingly, an interventional study with only associated discovery science activities would not be considered responsive to this FOA.

Any interventional study proposed must be within a project and not as a core activity. that the presence of a center structure is essential for the accomplishment of the research activities. It is expected that a RCTBPI will transform knowledge in the sciences it is studying.

Incremental work should not be the sole focus of center activities; rather, new and creative directions are required. Injury is the leading cause of death for Americans under the age of 44 years. In 2005, unintentional injury resulted in the death of more than 117,000 individuals per year in the United States (National Center for Health Statistics, http://www.

cdc. gov/ncipc/wisqars/), ranking fifth behind heart disease, cancer, stroke, and lung disease as a cause of death. The years of potential life lost due to trauma are significant.

Taking into account the potential years of life lost, the estimated cost of each trauma-related death in the United States is 2. 4 times more than that of cancer and cardiovascular disease combined. Based on the best available data, trauma will equal or surpass communicable diseases in 2020 as the number one cause of disability-adjusted life years worldwide.

social and economic impact of morbidity after injury also constitutes a significant public health issue. Trauma victims not killed by the initial injury may have prolonged and complicated recovery periods.

Similarly, surgical interventions for other disease conditions constitute a class of controlled injuries and have peri-operative complications, which are also a Advances in understanding the basic physiological responses to injury have yielded improved strategies of care, but, for a multitude of clinical problems, the scientific understanding needed to create effective new treatments is still lacking.

For example, scientists have developed some means to prevent early death after injury (such as aggressive fluid resuscitation after a severe burn), but victims then face various life-threatening complications well after the initial injury.

Research suggests that molecular, cellular, and systemic events occurring shortly after a traumatic event may be protective and precipitate programmed potential responses that cause complications immediately or much later. Ideally, appropriate therapeutic interventions shortly after injury would not only keep a patient alive, but also enhance repair and restoration.

The future of clinical care for victims of traumatic or burn injury, including treatment of the inevitable ensuing shock, depends on having a fundamental understanding of the physiological responses that occur at the molecular, cellular, tissue, organ, and systemic levels.

Applying newly available expertise and technology (e.g., genomics, proteomics, metabolomics, quantitative analytical approaches, and high-throughput testing) to clinical problems makes it possible to discover new interactions and physiological mechanisms. Simultaneously, scientists who understand the clinical issues faced by injured patients can offer specific direction for mechanistic laboratory investigations.

Approaching problems from multiple directions is necessary. injury is a complex systemic process that is difficult to address, particularly in narrowly defined individual research projects.

Moreover, funding mechanisms for independent, individual investigators (the R01 award, for example) necessarily limit the scope of their research projects, making the gathering of an adequate and appropriate diversity of expertise and insight often impossible. Studies of injured humans are difficult because of medical, scientific, and ethical reasons, but they are still possible and necessary.

The multi-component RCTBPI program offers investigators the opportunity to enhance the scientific effort from multiple perspectives and to allocate and leverage resources efficiently, thus allowing optimal research progress. Successful wound healing requires a complex and integrated interplay of different cell types, pathways, and processes.

Over the years, basic and clinical research has revealed much about the individual molecular and cellular processes involved in wound healing, but attempts to accelerate and/or improve wound healing by enhancing, inhibiting, or modifying isolated aspects of the wound-healing process have met with only limited success.

Previous progress was hampered by the limitations of animal model systems in mimicking human wound healing, gaps in the understanding of how the molecular and cellular processes of wound healing are interconnected and interdependent, and perceived barriers that have prevented scientific collaboration.

At this point in time, long-term research efforts by the wound healing community have produced a large and detailed knowledge base about many of the individual molecular and cellar processes involved in wound healing.

There is also a realization that break-through findings in wound healing will likely result from understanding the interdependencies of the individual wound-healing processes and that research efforts that target these kinds of questions will require the collaborative efforts of different scientists with diverse skills research for RCTBPI from NIGMS broadly covers the mechanisms of immediate and/or long-term adaptive and maladaptive physiological responses to injury (which is defined as blunt, penetrating, surgical, or burn injury and including hemorrhage occurring due to tissue damage).

This research includes but is not Whole organism, organ, tissue, cellular, and molecular responses (adaptive, compensatory, or dysfunctional), including shock (e.g., hypovolemic, cardiogenic, or septic) Mechanisms of cellular and organ failure (alterations in cellular bioenergetics, necrosis, apoptosis; single organ failure; and acute respiratory distress syndrome or multiple organ dysfunction syndrome) Resuscitation strategies and mechanisms Post-injury alterations of metabolic patterns and Normal or pathophysiological changes after injury and factors or therapies influencing stabilization and recovery Alterations in host-defense mechanisms (innate and adaptive immune mechanisms, systemic inflammatory response syndrome, compensatory anti-inflammatory response syndrome) Wound healing, tissue repair and regeneration, or tissue engineering related to repair of traumatic injuries Behavioral antecedents or consequences of trauma or burn injury as related to physiological responses, including effects of allostasis and allostatic load Individual, age-related, gender-specific, or population-specific responses to trauma, burn, or perioperative injury Mathematical and computational approaches needed to better understand the complex systems biology presented by injury and critical The time frame suitable for research is from immediately post-injury through ultimate resolution (recovery or death).

Research topics derived from complications faced by critically ill patients in intensive care units may be responsive to this FOA. In general, applications should address systemic responses to injury and acute critical illness. Applications should not focus on a single organ system, rather multi-system perspectives are encouraged.

In particular, applications that focus only on traumatic brain injury or spinal cord injury or on topics related to epidemiology, prevention of injury, social or behavioral factors that may increase the probability of injury, psychological trauma, long-term rehabilitation strategies, or delivery of health care are outside the mission of NIGMS.

Projects may include research on the nervous systems involvement in the systemic response to injury or specific subprojects on brain, spinal cord, or nerve injury if the overall focus fits within the topics listed above and most of the other research proposed does not center on the nervous system. Similarly, some epidemiological effort may fit well within the general theme of a RCTBPI, but it may not be the predominant element of study.

related to trauma are far-reaching. Applicants are encouraged to leverage the scientific endeavor and infrastructure created by this centers program to seek additional funding from other appropriate Federal agencies or private sources for related activities, such as the application of research findings to patient care and public outreach and education activities.

The ability to obtain institutional and other support for these activities would be viewed as enhancing the chances for success of the RCTBPI application. Elements and Organization of As stated above, each center must be an integrated, coordinated effort, featuring collaborations and team approaches that render it more than a collection of largely independent R01 projects.

Project integration may be reflected in the scientific interdependence of the subprojects and/or shared leadership of the subprojects. It also should be evident in the governance of the Center. The integration of the proposed research projects and of the research team is a key factor that will be assessed in peer review.

The benefits to be achieved through the establishment of multidisciplinary teams and novel collaborations, as opposed to working independently, must be described fully.

The applicant should identify clearly in the abstract, and more fully in the research plan, the overall theme of the RCTBPI and how translational research will be The minimum requirements for a RCTBPI will be three independent research subprojects led by faculty-level participants, and an Administration Core. Additional cores or shared resources may be proposed as appropriate to each center.

A separate Human Subjects Core is possible to maximize efficiency and quality for patient-oriented research, generation and maintenance of a clinical database, and/or generation and distribution of biological samples to subprojects. It is important however that this Human Subjects Core or any other core not contain hypothesis-driven or discovery studies, which need to be placed within the subprojects in the RCTBPI.

NIGMS is not specifying a maximum number of projects, cores or participants; rather, the size of a center should be a function of the science as well as the available funds (see below). The anticipated effectiveness of the proposed RCTBPI structure will be a criterion of the peer-review evaluation prior to an award and will be monitored after an award is made.

Proposed subprojects should have the research scope and depth typical for R01 applications. Applicants should describe collaborative and interdependent research subprojects as well as mechanisms for promoting scientific interactions among the participants. Plans must be presented for effective team communication and coordination of effort that covers the development, implementation, and conduct of all aspects of the research program.

It is essential to justify the proposed center in terms of the "value added" beyond what would be expected from a set of independent R01-style projects. Synergy between subprojects is desirable but not absolutely necessary if a case may be made that a particular subproject benefits from inclusion into the RCTBPI or that the overall center benefits from a non-synergistic subproject.

Regardless of the synergy however, all component parts of the RCTBPI must be interactive. Subprojects and overall RCTBPI applications that are multidisciplinary in nature are encouraged. research resources providing essential services, techniques, or instrumentation to the RCTBPI subprojects, thus enabling more efficient and effective conduct of the research.

Cores must be well-justified central components of the center and clearly non-redundant with support provided within the subprojects or elsewhere in the institution. At a minimum, a core must be used by at least 2 subprojects. Ideally, although not required, cores also should attempt to increase interactions between the center participants.

Whereas cores may also have developmental aspects as part of their overall function, specific hypothesis- or discovery-based research questions must be contained within presented for each subproject and core. This time line should outline the expected goals within the time frame requested for the award. The time line will help NIGMS evaluate progress toward the centers goals.

Explicit, quantitative milestones for projects are also recommended for all aspects of Administration and Management complexity of research centers, including collaborative and/or interdependent research projects as well as shared resources, a well thought out and carefully described management plan that ensures that the interests of all participants are represented will be required.

Within the context of the Administrative Core, plans must be presented for the proper strategic and day-to-day handling of the center. The RCTBPI application must specify the administrative and organizational structure(s) that will be used to support the research, and the synergies enabled by those structures as well as how each component part contributes to the centers overall cohesion.

Or, for those situations where a subproject may not be synergistic with the others, a clear explanation of the benefits of inclusion must be provided. The PD/PI of the RCTBPR will be responsible for ensuring that scientific goals are met and for developing and managing a decision-making structure and process that will allow resources to be allocated equitably in order to meet those scientific goals.

To that end, the PD/PI must describe how the scientific focus will be maintained in the overall project and in each of the subprojects, as well as the measures to ensure that progress is strong and steady. It is expected that the overall RCTBPI Director should commit at least 10% effort to the administration of the center; research effort would be in excess of this level of effort.

One or more associate directors should be named as well, with a clearly defined administrative hierarchy presented. A plan covering succession of leadership While it is anticipated that most RCTBPI applications will include participants from one institution, those that involve participants from more than one physical site are welcome under this FOA.

If any of the components is physically separated from the others (e.g., different departments or institutions), the applicant should describe how interactions will be facilitated.

The signature of the authorized organizational official on the Face Page signifies that the applicant and all proposed consortium participants understand and agree to the following statement: The appropriate programmatic and administrative personnel of each organization involved in this grant application are aware of the NIH consortium agreement policy and are prepared to establish the necessary inter-organizational agreement(s) consistent with that policy.

A separate statement is no longer required. Projects of the anticipated degree of complexity, both scientific and managerial, will require a substantial investment of the PI's effort.

The PD/PI for each subproject and core will be required to devote sufficient effort to ensure successful leadership and implementation of the goals of his/her individual part as well advisory boards of research scientists who are not involved in the center may be used to provide independent assessment and advice to the RCTBPI PD/PI and other participants.

The boards would be appointed by the RCTBPI PD/PI and confer as often as required in the manner most efficient for the given situation. Such advisory boards are not a requirement of this PAR but are suggested as a useful resource for the RCTBPI leadership.

If either internal or external advisory boards are to be used, the Administrative Core should provide clear descriptions of how members will be selected; how, when, and where meetings will be held; and how information and suggestions/recommendations flow between the board(s) and RCTBPI participants.

Specific membership for advisory boards should not be named in The Administrative Core should delineate means for ongoing evaluation of each component part of the RCTBPI and describe the framework through which problems (such as under-performing subprojects or cores; scientific changes created through the normal process of progress within or outside the center; internal conflicts over resources, concepts, or publications; etc.) are handled.

Examples of Administrative Core functions include but are not limited to: Oversight of financial considerations and all pertinent issues related to animal care and usage, safety, responsible conduct of science, Institutional Review Boards, and inclusion of human subjects (which may be addressed in the Human Subjects Core, if included in the proposal) Scientific management, including monitoring of the progress of subprojects and cores, mechanisms to foster interactions, and means to assure dissemination of research results Administration of a home page (see "HOME PAGE" below), including expertise to maintain and update the home page Institutional development activities, including coordination of efforts, management of resources, handling and referral of inquiries, follow-up activities, and monitoring of progress Communication with NIGMS and other funded RCTBPI programs (directly or through NIGMS) Provision of ready access to statistical expertise Travel requirements (including attendance at the annual meeting of RCTBPI Directors and NIH staff).

activities included in the application must be detailed. The Administrative Core will be responsible for outreach activities to both further the overall aims and objectives of the RCTBPI and help define the RCTBPI as a focal point for trauma, burn, and peri-operative injury activities within the home institution.

Outreach activities might include a seminar series, guest lectures, research day, workshops, mentor-training courses, symposia, learning experiences (for RCTBPI participants or individuals in the home institution or surrounding community), mini-sabbaticals, or other educational activities.

Travel funds may be used by RCTBPI participants to learn new laboratory techniques at different sites or to bring experts into the RCTBPI for a short period of time, as well as to develop new collaborations or engage in scientific information exchange.

While there is neither a minimal nor maximal amount of institutional outreach activities allowable, each application should propose what will best enhance achieving the overall goals and objectives of translational research, acquisition and management of human subjects may be consolidated within a separate Human Subjects Core, rather than keeping all aspects of these studies with the relevant subproject(s).

Establishing a Human Subjects Core may be effective if a significant portion of the RCTBPI will focus on the study of injured, burned, or critically ill patients (by studies of isolated cell and tissue samples or physiological assessments of individuals and appropriate controls).

The Human Subjects Core could have responsibility, for example, for development and implementation of standard operating procedures, recruitment and obtaining consent of subjects, collection and distribution of samples, keeping of all records and coordination with subprojects. A particular individual who will directly supervise the cores functions and activities should be specified.

To support these activities, up to $250,000 in direct costs per year above the limits specified in the section on "MECHANISM OF SUPPORT" (see below) may be requested for personnel such as research nurses or data managers and for necessary supplies, patient care, consultant fees, and other pertinent expenses.

Furthermore, if opportunities arise for multi-institutional research studies involving injured humans, the Human Subjects Core may serve as a focal point and/or resource for recruitment, accrual, and coordination of patients and/or samples. Please note that the Human Subjects Core is meant for consolidation and efficient handling of patient-oriented research and is not to be used for proposing or running of actual research protocols.

Rather, all experiments, either hypothesis- or discovery-based or interventional, must be proposed and managed within the subprojects. All subprojects will receive an impact/priority score within the peer review process while the Human Subject Core (like other cores) will simply be rated as acceptable/unacceptable.

Thus, to assure that all experiments on human subjects receive the full benefit of peer review, it is inappropriate to include such experiments in cores. Personnel and NIGMS Staff attend an annual meeting of NIGMS staff and other RCTBPI personnel. Other participants from the Federal government and/or other institutions and organizations may be invited as appropriate.

The goals for this meeting will be to share scientific information, assess progress, solve problems, identify new research opportunities, and establish priorities for enhancing the translation of advances to and from each RCTBPI. The meeting will likely be held on or near the NIH campus or at an alternative location if coordinating with the timing of a national scientific meeting.

At is discretion, NIGMS may consider the award of supplemental funds to support this planning activity if the expense for hosting the meeting becomes the responsibility of one or more RCTBPI; however, all requests for supplemental funds must included verification that funds are currently unavailable to cover these costs, including re-budgeting from other cost categories.

compelling need to promote diversity in the biomedical, behavioral, clinical, and social sciences workforce.

The NIH expects efforts to diversify the workforce to lead to the recruitment of the most talented researchers from all groups; to improve the quality of the educational and training environment to balance and broaden the perspectives in setting research priorities; to improve the ability to recruit subjects from diverse backgrounds into clinical research protocols; and to improve the Nations capacity to address and eliminate health encourages RCTBPI applicants to diversify their investigator populations and thus increase participation of individuals currently under-represented in the biomedical, behavioral, clinical, and social sciences such as: individuals from under-represented racial and ethnic groups, individuals with disabilities, and individuals from socially, culturally, economically, or educationally disadvantaged backgrounds that have inhibited their ability to pursue a career in health-related research.

VIII, Other Information - Required Federal Citations , for policies related to this announcement. opportunity announcement (FOA) will use the P50 Research Center grant award mechanism. The applicant will be solely responsible for planning, directing, and executing the FOA uses Just-in-Time information concepts.

It also uses non-modular budget formats described in the PHS 398 application instructions (see http://grants. nih. gov/grants/funding/phs398/phs398.

html ). does not have an anticipated number of awards but will fund the meritorious applications given available monies existing under normal applicant may request up to $7 million direct costs (exclusive of subcontractual facilities and administrative costs) for the entire 5-year project period. Requests for large equipment necessary for the proposed research may be included in excess of this cap.

If a Human Subjects Core is included, applicants may request funds above the $7 million direct costs for 5 years, but may not exceed $250,000 per year. anticipated start date will be no sooner than June 2009 and no later than September the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

Although the financial plans of the NIGMS provide support for this program, awards pursuant to this funding opportunity are contingent upon the and administrative costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004 . grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA . III.

Eligibility Information organizations/institutions are eligible to apply: Public/State Controlled Institutions of Private Institutions of Higher Education Black Colleges and Universities (HBCUs) Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without