Research Grants (Autumn Call - exclusively dedicated to Trisomy 21 research)

Research Grants (Autumn Call - exclusively dedicated to Trisomy 21 research) is sponsored by Jérôme Lejeune Foundation. This call supports fundamental, translational, and clinical research projects specifically focused on Down syndrome (Trisomy 21). The program offers both pilot/exploratory grants for early-stage projects and advanced grants for larger, breakthrough projects.

Jérôme Lejeune Foundation Research Jérôme Lejeune Foundation Research Funding Groundbreaking Research Created in 1995, the Fondation Jérôme Lejeune initiates, develops and finances fundamental, translational and clinical research programs in Down syndrome and other intellectual disabilities of genetic origin.

Our ultimate goal is to identify potential targets for intervention and advance the development of drugs and therapies that will offer patients the opportunity to lead healthier, longer and fulfilling lives. We support innovative research that has the potential to deepen our knowledge of these diseases and that can advance the discovery and development of therapies and treatments.

Likewise, we sponsor research on pathologies associated with Down syndrome that are also present in the general population (e.g. cardiopathies, leukaemia, sleep apnoea, Alzheimer’s disease). This strategy, which we termed research on cross-pathologies/co-occurrent diseases, enables to pool efforts, cross-reference results and develop molecules for the benefit of several therapeutic targets.

We are passionate about finding and funding the most creative and promising research projects and talented scientists, and each year, our scientific advisory board and external reviewers evaluate over 100 grants and postdoctoral fellowship applications to select the most outstanding ones for funding.

The Fondation Jérôme Lejeune is a major funder and incubator of research, facilitating research projects through various grant schemes and fostering researchers’ connections by sponsoring events of major scientific interest and impact in the field.

Recognized as a public utility institution, the Fondation Jérôme Lejeune is the leading project-based funding agency of research on Down syndrome and other intellectual disabilities in France. Four types of funding schemes are available for research projects. Evaluation is conducted by our Scientific Advisory Board and/or external reviewers.

For events, refer to the following button . Our research grants program supports fundamental, translational and clinical research projects. We support early stage and advanced projects for a period of up to two years.

The Autumn call is exclusively dedicated to Trisomy 21 research. Eligibility: Principal investigator is the applicant and must hold a permanent position within an academic institution at least for the duration of the research project. Calls for proposals: Twice a year.

Pilot or exploratory grants: 50. 000 € Advanced grants: 80. 000 € The Jérôme Lejeune Postdoctoral Fellowships are awarded for a period of up to two years and support excellent postdoctoral researchers working in academia.

Each year the call is focused on a specific topic in Down syndrome research. Eligibility: Applicants must hold a doctorate degree or equivalent at the start of the fellowship. Applicants who already hold a PhD degree are eligible up to six years after obtention of their PhD degree.

Calls for proposals : Once a year in December Award amount : 130. 000 € over 2 years This prize aims to reward and encourage the work of talented young researchers that are developing or have developed projects with therapeutic potential for Down syndrome or other intellectual disabilities.

Eligibility: Be enrolled in at least the second year of a PhD program or have defended their PhD thesis no more than one year before the submission date. Carry out your research work within a French institution. Calls for proposals : once a year in March These individual fellowships subsidize the 4 th year of a PhD program for students working on Down syndrome or Fragile X Syndrome .

The objective is to enable these young researchers to finalise their research project and publications in order to advance and pursue their scientific careers. Eligibility: Be enrolled in the third year of a PhD program within a French institution. Calls for proposals: once a year in February Award amount: 40.

000 € over 1 year To foster researchers’ connections, the Fondation Jérôme Lejeune may consider sponsoring events . Organizers are invited to submit a proposal throughout the year by submitting online this completed form and certificate of compliance in accordance with the appropriate guidelines .

Number of fellowships: 27 Number of scholarships: 4 The funds provided by the Fondation Jérôme Lejeune cannot in any way be used to purchase or make use of human embryonic or fetal tissues or another biological material obtained through abortions, IVF or human cloning or to create new human germinal cells.

The results of the research project cannot be published in the same article as the results of work carried out on human embryonic or fetal cells or tissues. The Fondation Jérôme Lejeune does not agree to be associated with such work. It is mandatory for researchers to follow the academic and national Good Laboratory Practices (GLP) .

Legendary geneticist Jérôme Lejeune in a rare interview in English. He co-discovered that Down Syndrome is caused by the trisomy of chromosome 21 For information related to our funding schemes, please contact : Fondation Jérôme Lejeune – Scientific Committee funding@fondationlejeune.

org Respire 21: OSA detection and treatment : recent publication in the Lancet Regional Health – Europe Spring 2024 Scientific board meeting Neurobehavioral dysfunction in a mouse model of Down syndrome: role of CBS/H2S pathway The technical storage or access that is used exclusively for anonymous statistical purposes.

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