Research Grants in Clinical Informatics (R01 Clinical Trial Optional) is sponsored by U.S. Department of Health and Human Services, National Institutes of Health (NIH). This NIH funding opportunity supports innovative clinical informatics research to transform health data into actionable knowledge. While broad, it can include projects leveraging AI for data analysis and integration to advance biomedical research.

Opportunity Listing - Research Grants in Clinical Informatics (R01 Clinical Trial Optional) Research Grants in Clinical Informatics (R01 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 879 -- Medical Library Assistance Last Updated: May 13, 2026 View version history on Grants. gov The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics.

The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery.

This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and... precision health care.

Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data.

The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

Nonprofits non-higher education with 501(c)(3) Other Native American tribal organizations Nonprofits non-higher education without 501(c)(3) For-profit organizations other than small businesses Private institutions of higher education Public and state institutions of higher education Independent school districts Public and Indian housing authorities Federally recognized Native American tribal governments Special district governments City or township governments Refer to Section III.

Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations.

This new requirement was effective, May 1, 2025. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding.

This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors. Grantor contact information File name Description Last updated PAR-26-042-Full-Announcement. html PAR-26-042-Full-Announcement.

html Feb 11, 2026 01:39 PM UTC Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.