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Find similar grantsResearch Infrastructure Programs - Construction is sponsored by Department of Health And Human Services. This opportunity supports mission-aligned projects and measurable outcomes.
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Extramural Construction Programs | Office of Research Infrastructure Programs (ORIP) – DPCPSI – NIH Extramural Construction Programs The overall objective of these programs is to provide modernized physical infrastructure that meets up-to-date engineering requirements to conduct cutting-edge NIH-funded biomedical research.
Such an investment in infrastructure offers long-term benefits because federally funded space must be used to support biomedical research for the next 10 years, depending on the regulatory requirement of an individual program. These investments impact research funded by essentially all NIH Institutes and Centers, benefiting all areas of biomedical sciences from fundamental biology to clinical translational research.
ORIP oversees the use of more than 300 research facilities in 45 states and in Puerto Rico that were funded in the last 20 years. These facilities provide new laboratory space, and set up environments for specialized research protocols and clinical investigations. For example, special facilities support antibody engineering for the development of cancer therapeutics and the synthesis of probes for positron emission tomography.
The projects created designated space, such as barrier facilities to study pathogens and prions, animal facilities in nonhuman primate research centers to research infectious diseases, and shielded rooms for magnetic resonance imaging.
PAR-26-106 “Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)” This NOFO supports two existing construction programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program. No advanced reservation is required.
PAR-25-061 "Biomedical Research Facilities (C06 Clinical Trial Not Allowed)" Deadline: January 27, 2025 PAR-24-033 "Limited Competition: Development and Renovation of Facilities for Expanding the Breeding Capacity of Specific Pathogen Free Non-Human Primates to Support HIV/AIDS-related Research (C06 Clinical Trial Not Allowed)" Deadline: January 7, 2025 Pre-Application Webinar Presentation: PAR-26-106 C06 Program: Frequently Asked Questions FY24 (PAR-23-306) Grantee Webinar Presentation American Recovery and Reinvestment Act (ARRA) Program ORIP oversaw and supported other special initiatives, such as the Extramural Research Facilities Restoration Program: Hurricane Sandy Disaster Relief, to recover the biomedical research capacity in affected states.
Two ORIP grant awards funded the rebuilding of rodent housing facilities and laboratory research space that were lost because of hurricane damage. Since its creation, ORIP has directed significant efforts toward the modernization of animal research facilities.
The funded projects, based on current technologies and engineering principles, improve resource efficiencies, contribute to the accuracy of experimental protocols, and benefit animal care. Various environmental factors may affect the physiology, metabolism, responses to drugs, and other experimental outcomes at the genetic, cellular, and whole organism levels.
For example, a rodents’ ability to hear high-frequency sounds makes them sensitive to noise and vibrations that are generated by heating, ventilation, and air conditioning (HVAC) units in a laboratory setting. Modern HVAC units provide an improved environment for research animals. Similarly, new automated systems monitor and adjust light cycles and intensity to match natural circadian rhythms of animals.
The installation of robotic feeding and watering systems allow accurate assessments of caloric intake, eating patterns, and food preferences. Often, new biological discoveries necessitate the modernization of laboratory space, so that targeted experimental protocols can be performed under well-defined conditions.
For example, a gnotobiotic environment is needed to conduct some studies that research the role of the microbiome in health and disease. Based on the aforementioned examples, the creation, renovation, and modernization of infrastructures are necessary to support cutting-edge biomedical research.
Emerging scientific fields require the support of novel and advanced engineering solutions to conduct robust and reproducible biomedical research. ORIP’s long-standing experience in supporting successful improvements to infrastructures, demonstrates its ability to continue these efforts.
Related Research Highlights ORIP’s C06 Builds a Powerhouse for Preclinical Imaging and Irradiation Research at Wake Forest University School of Medicine University of Miami Biospecimen Repository: Transforming Precision Medicine Research NIH-Funded Gnotobiotic Facility Advances Microbiome Research in Chronic Liver Diseases and Obese Conditions at the University of California, San Diego See More Research Highlights
According to the current listing, eligibility includes: Public/state controlled Nonprofit Institutions/Organizations; Private Institutions of Higher Education; Nonprofit other than Institutions of Higher Education Nonprofits with 501(c)(3) IRS status (Other than Institutions…. Confirm the full requirements in the official notice before applying.
The current listing shows recent federal obligations suggest $80,000,000 (2026). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Research Infrastructure Programs - Construction are due January 25, 2027. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Yes — Research Infrastructure Programs - Construction is offered by Department of Health And Human Services and this listing comes from SAM.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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Research Infrastructure Programs - Research Centers is sponsored by Department of Health And Human Services. The Office of Research Infrastructure Programs (ORIP), within the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) in the NIH Office of the Director, supports extramural biomedical research by strengthening the infrastructure that enables scientific discovery. ORIP advances human health by fostering the development of critical research models, biomaterials, and technologies; expanding access to state-of-the-art instrumentation and facilities; supporting education and training programs; and assisting small businesses in translating innovative technologies. Through its two divisions, the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI), ORIP plays a critical role in accelerating biomedical research nationwide. DCM develops and sustains essential research models and biological resources, manages the infrastructure required for their use and distribution, and provides training to ensure investigators have reliable access to high-quality models and facilities. DCI supports shared, cost-effective access to advanced scientific instrumentation, modernizing research facilities, and providing critical equipment that enables transformative biomedical discoveries. Together, DCM and DCI strengthen U.S. competitiveness and ensure the biomedical research community has the infrastructure necessary to address emerging health challenges, prevent disease, promote health, and advance foundational science. This listing is currently active. Program number: 93.3RC. Last updated on 2026-01-28.
Research Infrastructure Programs - Construction is sponsored by Department of Health And Human Services. The Office of Research Infrastructure Programs (ORIP), within the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) in the NIH Office of the Director, supports extramural biomedical research by strengthening the infrastructure that enables scientific discovery. ORIP advances human health by fostering the development of critical research models, biomaterials, and technologies; expanding access to state-of-the-art instrumentation and facilities; supporting education and training programs; and assisting small businesses in translating innovative technologies. Through its two divisions, the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI), ORIP plays a critical role in accelerating biomedical research nationwide. DCM develops and sustains essential research models and biological resources, manages the infrastructure required for their use and distribution, and provides training to ensure investigators have reliable access to high-quality models and facilities. DCI supports shared, cost-effective access to advanced scientific instrumentation, modernizing research facilities, and providing critical equipment that enables transformative biomedical discoveries. Together, DCM and DCI strengthen U.S. competitiveness and ensure the biomedical research community has the infrastructure necessary to address emerging health challenges, prevent disease, promote health, and advance foundational science. This listing is currently active. Program number: 93.CN1. Last updated on 2026-01-28.
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