Research to Advance the Science of Primary Care (R01)

Research to Advance the Science of Primary Care (R01) is sponsored by Agency for Healthcare Research and Quality. Supports research to build evidence on primary care characteristics influencing patient outcomes and health equity.

Expired PA-24-205: Research to Advance the Science of Primary Care (R01) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1. Overview Information Participating Organization(s) Agency for Healthcare Research and Quality ( AHRQ ) NOTE: The policies, guidelines, terms, and conditions stated in this announcement may differ from those used by the NIH.

Where this Notice of Funding Opportunity (NOFO) provides specific written guidance that may differ from the general guidance provided in the grant application form, please follow the instructions given in this NOFO. Also note that AHRQ may have different page limits than NIH for the application Research Strategy, which can be found within each individual NOFO.

of Participating Organizations Funding Opportunity Title Research to Advance the Science of Primary March 6, 2026 - Notice of Early Expiration PA-24-205 -- Research to Advance the Science of Primary Care (R01). See Notice NOT-HS-26-001 March 31, 2025 - This funding opportunity was updated to align with agency priorities.

Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 2024 - Notice of Intent to Publish a Funding Opportunity Announcement for Research to Advance the Science of Primary Care (R01).

See 7, 2024 - Guidance on Salary Limitation for Grants and Cooperative Agreements FY 2024. See NOT-HS-24-007 . 16, 2023 - Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Improve Healthcare for Persons Living with Disabilities.

See Notice NOT-HS-24-004 . 2023 - Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Advance Health and Healthcare Equity. See NOT-HS-23-013.

26, 2023 - AHRQ Small Research Projects to Advance the Science of Primary Care (R03). See 11, 2022 - Competitive Revision Supplements to Existing AHRQ Grants and Cooperative Agreements to Enhance Workforce Diversity in Health Services Research. See PA-22-175 21, 2023 - Reminder of eRA Commons ID Requirement for All Personnel on the R&R Senior/Key Person Profile Form.

See Notice NOT-OD-24-042 . 11, 2019 - AHRQ Announces Change in Grant Recipient Purchasing of Identifiable CMS Data, effective FY2019. See NOT-HS-19-007 .

October 5, 2016 - AHRQ Policy Guidance Regarding Inflationary Increases (aka, cost-of-living adjustments, or COLAs) beginning in Fiscal Year 2017. See NOT-HS-17-001 . Notice of Funding Opportunity (NOFO) Number Companion Funding Opportunity Additional Information on Eligibility .

Assistance Listing Number(s) Funding Opportunity Purpose The purpose of this Notice of Funding Opportunity (NOFO) is to build evidence about the characteristics and value of primary care that influence patient outcomes and advance health equity, such as care coordination, continuity of care, and comprehensiveness of care, person-centered, whole healthcare, and trust, and how these can be improved and effectively delivered to strengthen primary healthcare.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) dates apply. The first application due date is June 5, 2024. All applications are due by 5:00 PM local time of Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s) Generally, four months after receipt date. Generally, four months after the scientific merit review New Date March 6, 2026 per issuance of NOT-HS-26-001 . (Original Expiration Date: November 6, 2029) It is critical that applicants follow the Research (R) Instructions (R&R) Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV and follow the AHRQ Grants Policy and Guidance found on the AHRQ website at http://www. ahrq.

gov/funding/policies/nofoguidance/index. html . the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of the Announcement I. Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement I. Funding Opportunity Description The mission of the Agency for Healthcare Research and Quality (AHRQ) is to produce evidence to make healthcare safer, higher quality, and more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure the evidence is understood and used.

Primary care is a core component of the United States healthcare system, and a strong primary care foundation is necessary to the health of people and populations.

The COVID-19 pandemic has made the multitude of challenges facing primary care more visible and more severe, including workforce shortages, attrition, and burnout; unsustainable primary care payment, underfunding and underspending; inequitable access, increasing disparities, and lack of affordability; fragmentation and shifting practice organization and ownership; an aging and complex patient population with a high burden of multimorbidity, and the impact of climate change and other natural and manmade events on individual and population health.

In 2021, the NASEM Report, "Implementing High-Quality Primary Care: Rebuilding the Foundation of Health Care" emphasized the need for an increased investment in primary care research to build the evidence base underlying quality primary care and inform and transform the delivery of Primary care research is critical to AHRQ's mission and vital to ensure a strong primary care foundation.

Per the 2021 NASEM Report, AHRQ defines high quality primary care as: The provision of whole-person, integrated, accessible, and equitable healthcare by interprofessional teams who are accountable for addressing the majority of an individual’s health and wellness needs across settings and through sustained relationships with patients, families, and communities.

Primary care research is research conducted for the purpose of better understanding or improving primary care; more specifically, it is research that is a) conducted in a primary care setting, b) about primary care patients, clinicians, or teams, or c) on a topic that is integral to, or has direct implications for, the delivery of primary AHRQ funds and disseminates research on primary care systems and innovations, including primary care as the usual source for addressing personal healthcare needs and providing whole person healthcare, the management of commonly occurring and undifferentiated clinical problems, and the continuity and coordination of health services.

AHRQ has made significant investments in research to understand how to improve primary care including investing in primary care training and practice-based research networks, integrating behavioral health and primary care, and evaluating the patient-centered medical home and the costs of primary care transformation.

Through this NOFO, AHRQ will support innovative research to find actionable solutions to the challenges confronting primary care that can be scaled and spread across The purpose of this Notice of Funding Opportunity (NOFO) is to advance the understanding of the role, capacity, and value of primary care to improve patient outcomes and population health by delivering whole healthcare across the life course, and to build evidence about the characteristics and value of primary care that influence patient outcomes and advance health equity, such as care coordination, continuity of care, and comprehensiveness of care, person-centered, whole healthcare, and trust, and how these can be improved and effectively delivered to strengthen primary healthcare.

Answering these critical questions is necessary to revitalize primary care in a way that improves individual and population health while increasing access to care, reducing burden on patients and clinicians, and improving equity and quality of care.

The overarching objective of this NOFO is to advance understanding of the role and capacity of primary care to increase the value and quality of care and improve patient outcomes and population health by delivering person-centered care.

This NOFO will prioritize research projects that aim to improve primary care in terms of quality, safety, access, affordability, and equity, which may include attention to the primary care workforce, patient experience or outcomes, social determinants of health, care delivery models, payment, or digital healthcare.

The research strategy proposed by applicants must be related to the mission and research interests of AHRQ and its National Center for Excellence in Primary Care Research (NCEPCR). Within AHRQ’s mission, the primary care-specific priority areas of focus are: 1.

Research to improve primary care, including regarding quality, safety, access and affordability, the workforce, care delivery models, financing, digital healthcare, person-centeredness, and health equity. 2.

Harnessing data and technology to conduct research on characteristics of primary care that may influence patient outcomes, such as person-centered whole healthcare, care coordination, continuity of care, and comprehensiveness of care. 3.

Research on management of clinical areas unique to primary care, such as multiple chronic conditions, preventive care, undifferentiated syndromes, or behavioral and mental healthcare that is integrated within primary care.

Topics: This NOFO aims to support research that a) builds evidence about the characteristics of primary care that influence patient outcomes, such as care coordination, continuity of care, comprehensiveness of care, person-centered, whole healthcare, clinician-patient relationships, and trust; b) focuses on care provided in primary healthcare settings and/or practices; and c) focuses on clinical areas unique to primary care, such as prevention and management of multiple chronic conditions, preventive care and implementation of the United States Preventive Services Task Force (USPSTF) recommendations, undifferentiated syndromes, or behavioral and mental healthcare that is integrated within primary care.

In addition, projects that examine the role of primary care throughout the life course, including pediatric and adolescent health, transition from pediatric to adult care, sexual and reproductive health, women's health, perinatal care, men's health, and geriatric care and aging are welcome, as are studies focused on reducing patient and clinician burden, increasing trust between patients, clinicians, and clinical teams, and the healthcare system, and addressing time-related issues and concerns in healthcare delivery.

This NOFO strongly encourages a focus on issues that address health disparities and have the potential to improve health equity in terms of race and ethnicity, gender, socioeconomic status, age, disability, or geography/rurality.

All projects must include a discussion regarding how their research might be implemented or used to improve delivery of primary care or patient outcomes, and how improvements from the evidence generated could be sustained.

studying person-centered care planning and care coordination are encouraged to consider use of open-source tools developed through the Multiple Chronic Conditions Electronic Care Plan project to improve interoperability of data for people living with multiple chronic conditions. Such tools include SMART on FHIR care planning applications, FHIR data standards, and value sets from common clinical terminologies.

The tools are available on the Agency for Healthcare Research and Quality's (AHRQ) eCare Plan webpage. Methodologies: This NOFO will support primary care research projects that propose methodology, technology, theoretical frameworks, conceptual models, or practice innovation that may lead to new ways to facilitate and implement the redesign of primary care and its critical role in healthcare systems.

AHRQ welcomes innovative methodologies and approaches that will accelerate evidence development to support primary care transformation. Methodologies and theoretical/analytic approaches may include, but are not limited to, rapid cycle research, partnership research, agile implementation, journey mapping, complex adaptive designs, intersectionality, critical theories, chaos theory, and complexity science.

AHRQ is interested in evidence generation from practice-based data and qualitative and mixed methods. AHRQ encourages projects that produce and disseminate timely insights that can be used to improve patient care and inform healthcare delivery at multiple levels and that can be spread and scaled.

All projects must describe methods and theoretical frameworks relevant for advancing issues in primary care Partnerships: Applicants are encouraged to partner with practices, clinicians, communities, and patients using innovative approaches to evaluation with patients and communities.

In this NOFO, AHRQ is particularly interested in applications that leverage the infrastructure, expertise, and relationships of primary care practice-based research networks (PBRNs). AHRQ defines a PBRN as a group of ambulatory practices devoted principally to the primary care of patients and affiliated in their mission to investigate questions related to primary care.

Applicants are also encouraged to demonstrate (e.g., in research design, methodological approach, with a letter of support, etc.) engagement with relevant end users (such as a health system, practice, payer, policymaker, applicant institution, etc.) that can implement a practice improvement, policy, or other change based on the Sample primary care research areas relevant to this NOFO include, The role of primary care throughout the life course or at a particular point in the lifespan, including pediatric and adolescent health, transition from pediatric to adult care, sexual and reproductive health, women's health, perinatal care, and geriatric care and aging.

The role of primary care in improving infant and maternal mortality, including caring for prenatal and postpartum women, prevention of cardiovascular issues during pregnancy.

The role of primary care in improving women’s health outcomes, including an increased focus on evidence-based preventative care and early intervention (e.g., through contraception, pre-conception screening and menopause management); building trusting patient-clinician relationships; and an understanding of social and cultural determinants of health that uniquely The role of primary care in optimizing health and function as people age, including preventive care, managing and coordinating care, and person-centered care planning for older patients at risk for or living with multiple chronic conditions, as well as those experiencing normal changes that come with aging, including menopause, functional decline/frailty, and other physical and mental-behavioral health issues.

The role of primary care in response to pandemics, natural and man-made disasters, climate change, or other national health emergencies, and the impact of these events on primary care delivery and the health system, including in minoritized and socioeconomically disadvantaged communities, and in older adults and people living with disabilities.

Measurement of key aspects of primary care, such as comprehensiveness, care coordination, or team performance in diverse primary care settings.

Characteristics and value of primary care that influence patient outcomes and advance health equity, such as care coordination, continuity of care, comprehensiveness of care, person-centered care, whole healthcare, and The delivery of person-centered, whole healthcare (see NASEM report) that addresses social determinants of health.

The impact of primary care patient-clinician relationships, trust between and among patients, clinicians, and the healthcare system, and the effect on outcomes and experience.

Primary care workforce issues, including research that contributes to understanding approaches to support, develop, retain, and grow this workforce and to further understanding and improvement of burnout, moral Time-related issues and concerns in primary healthcare delivery, such as electronic health record burden, patient wait times, how time is spent in a limited primary care patient visit, impact of time pressure on clinician wellbeing and joy in practice, and systems-level structures that impact how clinician and patient time is valued and used.

Interprofessional primary care team composition and configurations and their impact on patient experience of care and health The interface of primary care with pediatric and adult subspecialties, including testing innovative approaches to more effective collaboration, referral, and coordination of care. Challenges and solutions to providing quality primary care to rural and remote areas as well as underserved urban communities.

The impact of financing models, payment, and reimbursement on the ability of primary care to deliver quality care. The impact of shifting primary care practice ownership and settings of primary care delivery on patient and clinician experience, patient outcomes, and quality of care. The impact of community-based and public health partnerships on patient and clinician experience, patient outcomes, and quality of care.

Effective approaches to integrate behavioral health into primary The use of digital healthcare (including electronic health records, electronic care plans, clinical decision support tools, telehealth, apps, etc.) and technology to improve the delivery of high-quality primary care.

Clinical areas unique to primary care, such as multiple chronic conditions, preventive care and implementation of USPSTF recommendations, undifferentiated syndromes, and behavioral and mental healthcare that is integrated within primary care. Implementation science to translate evidence more rapidly into Any other significant issues or challenges primary care practices face and innovative solutions targeting them.

Information for award authorities and regulations. Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed Optional: Accepting applications that either propose or do not propose clinical trial(s) help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon AHRQ appropriations and the submission of a sufficient number of meritorious Future year funding is contingent upon the availability of funds for each year of support. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

The total costs (direct and indirect) for a project awarded under this NOFO will not exceed $500,000 in any given year and $2. 5 million for the entire project period. Applications requesting more than $500,000 in any one year will not be reviewed.

Funds may be used only for those expenses that are directly related and necessary to the project and must be expended in compliance with applicable Uniform Administrative Requirements, Cost Principles, and Audit Requirements for HHS Awards (45 CFR Part 75) and the The project period may not These projects are being funded pursuant to 42 U.S.C.

299a, which provides that AHRQ shall conduct and support research, support demonstration projects, and disseminate information on healthcare and on systems for the delivery of such care, including activities with respect to the quality, effectiveness, efficiency, appropriateness, and value of healthcare All applications submitted and AHRQ grants made in response to this NOFO are subject to 45 CFR Part 75 (Uniform Administrative Requirements, Cost Principles and Audit Requirements for HHS Awards; https://www.

ecfr. gov/cgi-bin/text-idx? node=pt45.

1. 75) , the HHS Grants Policy Statement (see https://www. ahrq.

gov/funding/policies/hhspolicy/index. html ), and the terms and conditions set forth in the Notice of Award.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for AHRQ support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations AHRQ's authorizing legislation does not allow for-profit organizations to be eligible to lead applications under this research mechanism.

For-profit organizations may participate in projects as members of consortia or as subcontractors only. Because the purpose of this program is to improve healthcare in the United States, foreign institutions may participate in projects as members of consortia or as subcontractors only. Applications submitted by for-profit organizations or foreign institutions will not be reviewed.

Organizations described in section 501(c) 4 of the Internal Revenue Code that engage in lobbying are not eligible. HHS grants policy requires that the grant recipient perform a substantive role in the conduct of the planned project or program activity and not merely serve as a conduit of funds to another party or parties.

If consortium/contractual activities represent a significant portion of the overall project, the applicant must justify why the applicant organization, rather than the party(s) performing this portion of the overall project, should be the recipient and what substantive role the applicant organization will play.

Justification can be provided in the Specific Aims or Research Strategy section of the PHS398 Research Plan Component sections of the SF424 (R&R) application. There is no budget allocation guideline for determining substantial involvement; determination of substantial involvement is based on a review of the primary project activities for which grant support is provided and the organization(s) that will be performing those activities.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as Award Management (SAM) Applicants must complete and maintain an active requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Entity Identifier (UEI)- A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Applicants must have an active SAM registration in order to complete the Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide. The AHRQ multiple PDs/PIs policy can be found at https://grants. nih.

gov/grants/guide/notice-files/NOT-HS-16-018. html . The total PD/PI level of effort must be at least 20% annual full-time effort (i.e., at least 8 hours per week) in each given year of the This NOFO does not require cost sharing.

While there is no cost sharing requirement included in this NOFO, AHRQ welcomes applicant institutions, including any collaborating institutions, to devote resources to this effort. An indication of institutional support from the applicant and its collaborators indicates a greater potential of success and sustainability of the project.

Examples of institutional support would include: donated equipment and space, institutional funded staff time and effort, or other resource investments. Applicant institutions should indicate institutional support by outlining the specific contributions to the project and providing assurances that their organization and any collaborators are committed to providing these funds and resources to the project.

This information can be included at the end of the budget justification section of the application, but institutional support dollars are not to be shown/included in the detailed budget request. 3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The AHRQ will not accept duplicate or highly overlapping applications under review at the same time. This means that the AHRQ will A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

and Submission Information The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the Research (R) Instructions (R&R) Application Guide , except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for For this specific NOFO, the Research Strategy section is All page limitations described in the SF424 Application Page Limits must be followed. Instructions for Application Submission The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this NOFO.

All instructions in the SF424 (R&R) Application Guide SF424(R&R) Project/Performance Site Locations All instructions in the SF424 (R&R) Application Guide SF424(R&R) Other Project Information All instructions in the SF424 (R&R) Application Guide SF424(R&R) Senior/Key Person Profile All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide Budget Component: Special Instructions for AHRQ applications AHRQ is not using the Modular Grant Application and Award Process.

Applicants applying for funding from AHRQ are to ignore application instructions concerning the Modular Grant Application and Award Process and prepare applications using instructions for the Research and Related Budget Components of the SF 424 (R&R). Applications submitted in the Modular format will not be reviewed.

All instructions in the SF424 (R&R) Application Guide PHS 398 Cover Page Supplement All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: management plan is required.

AHRQ applicants are reminded to refer to NOT-HS-20-011: The Agency for Healthcare Research and Quality Data Management https://grants. nih. gov/grants/guide/notice-files/NOT-HS-20-011.

html ) for additional information on how to incorporate their data management plan into the resource sharing plan. Sharing Plans are expected, but they are not applicable for this NOFO. Do not use the Appendix to circumvent page limits.

Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.

See NIH/NIOSH/AHRQ New Policy Appendix Guide located PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions: If you answered Yes to the question Are Human Subjects Involved?

on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Record: PHS Human Subjects and Clinical Trials Information All instructions in the SF424 (R&R) Application Guide onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start).

All instructions in the SF424 (R&R) Application Guide must be followed. For details regarding IRB approval, applicants may refer to the "AHRQ Revised Policy for Institutional Review Board (IRB) Review of Human Subjects Protocols in Grant Applications" ( https://grants. nih.

gov/grants/guide/notice-files/not-hs-00-003. html ). Applicant should also be aware of the AHRQ policy for use of single IRB for cooperative research, 45 CFR 46.

114 (b) https://grants. nih. gov/grants/guide/notice-files/NOT-HS-20-005.

html . PHS Assignment Request Form All instructions in the SF424 (R&R) Application Guide 3. Unique Entity Identifier and System for Award Management (SAM) See Part 1.

Section III. 1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants. gov. Part I.

Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next Organizations must submit applications to Grants.

gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants administration. AHRQ and Grants.

gov systems check the application against many of the application instructions upon submission. Errors must be corrected, and a changed/corrected application must be submitted to Grants. gov on or before the application due date and time.

If a Changed/Corrected application is submitted after the deadline, the application will be considered late. are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission. Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

This initiative is not subject to intergovernmental For efficient grant administration, AHRQ grant administration procedures will be used and conducted in accordance with the terms and conditions, cost principles, and other considerations described in the HHS Grants Policy Statement. The HHS Grants