Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) is sponsored by U.S. Department of Health and Human Services; Office of Research Infrastructure Programs; National Institutes of Health. This grant supports the development of broad-impact models and related materials for studying human health and diseases.

This directly aligns with the focus on modeling in infectious disease and immunology.

Opportunity Listing - Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) Agency: National Institutes of Health Assistance Listings: 93.

351 -- Research Infrastructure Programs Last Updated: May 13, 2026 View version history on Grants.

gov The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease.

The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple... organ systems in order to align with the ORIP"s NIH-wide mission and programs.

Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted.

Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

City or township governments Federally recognized Native American tribal governments Nonprofits non-higher education without 501(c)(3) Nonprofits non-higher education with 501(c)(3) Private institutions of higher education Public and state institutions of higher education For-profit organizations other than small businesses Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.

Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information Office of Research Infrastructure Programs (ORIP) File name Description Last updated RFA-OD-25-010-Full-Announcement. html RFA-OD-25-010-Full-Announcement. html Dec 5, 2025 06:50 PM UTC RFA-OD-25-010-Revised-Full-Announcement.

html RFA-OD-25-010-Revised-Full-Announcement. html Dec 24, 2025 03:16 PM UTC Link to additional information Closing: September 28, 2028 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.