RFA: Cancer Health Research Centers (CHERCs)

RFA: Cancer Health Research Centers (CHERCs) is sponsored by American Cancer Society. Supports research centers focusing on cancer health equity, including cancer genomics.

Onpe page landing template with pricing & others RFA: Cancer Health Research Centers (CHERCs) Aesthetic and Cosmetic Surgery Endocrinology and Diabetes Leadership and Administration Microscopy and Cell Imaging Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba British Indian Ocean Territory Congo, the Democratic Republic of the Falkland Islands (Malvinas) French Southern Territories Heard Island and McDonald Mcdonald Islands Holy See (Vatican City State) Iran, Islamic Republic of Korea, Democratic People's Republic of Lao People's Democratic Republic Macedonia, the Former Yugoslav Republic of Micronesia, Federated States of Saint Helena, Ascension and Tristan da Cunha Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Sint Maarten (Dutch part) South Georgia and the South Sandwich Islands Tanzania, United Republic of United States Minor Outlying Islands Venezuela, Bolivarian Republic of Other (Select all that apply) RFA: Cancer Health Research Centers (CHERCs) Summer Cycles: New, renewal, and resubmitted applications will be accepted Winter Cycles: Only resubmissions of previously reviewed applications, including renewals, will be accepted; no new applications accepted.

LOIs Materials Available: December Application Materials Available: March Anticipated Start: April 1 LOI Materials Available: Not applicable Application Materials Available: September Applications Due: December 1 Anticipated Start: October 1 As part of the American Cancer Society (ACS) mission to promote fair and just opportunity to prevent, detect, treat, and survive cancer, we have created the Cancer Health Research Center (CHERC) program.

CHERCs are designed to address cancer health disparities that affect local or regional communities. Priority will be given to Centers that focus on actionable, solution-based research designed to improve the health of the community and advance our goals for achieving health equity and reducing cancer mortality.

Societal conditions where people are born, grow up, live, work, worship, and age, have a profound effect on their health, access to cancer care, and ability to carry out care recommendations. Health outcomes are impacted by intersecting factors of wealth, education, employment, geography, language, neighborhood, health systems, insurance coverage, and access to care.

There remains a critical need for research that seeks to better understand the context surrounding these health disparities, values community input, and proposes and tests viable solutions. Successful applications will propose well-designed research projects poised to make an impact on their local community within the framework of a coordinated center approach that's focused on demonstrated health inequities.

Projects may span the cancer continuum and include health promotion, cancer prevention, screening, treatment, access to care, care delivery, and/or survivorship. Community engagement is vital for successful implementation and should be central to the development of the CHERC.

The description of the CHERC should clearly present the center's overall scientific agenda, magnitude of the health inequity(ies) being addressed, thematic connection to the presented research, and how the CHERC achieves more as a unit, rather than conducted independently. There are many examples of health disparities affecting the population in the United States.

ACS has identified the following priority areas (additional topics may be considered with appropriate justification by the applicant): Rural Communities/Access to Health Racial/Ethnic Disparities - Asian, Hispanic, Black, American Indian/Alaskan Native, Native Hawaiian/Pacific Islander Age-specific Needs (pediatrics, adolescent/young adults, older adults) Environmental Justice (radon, climate change) Physical and Mental Disabilities This RFA is a call for solution-based research addressing cancer health disparities that will enable fair and just opportunities to prevent, detect, treat, and survive cancer for everyone.

Applicants should clearly demonstrate their ability to reach populations of interest and describe how the proposed methodologies will produce meaningful results. In support of its overall mission, the CHERC should include a Supportive Core that is managed and coordinated by the Principal Investigator (PI).

The Supportive Core should include operational and scientific activities designed to develop, promote, and enhance the scientific agenda of the CHERC, creating an optimal environment to address health equity research.

Acceptable activities may include developing commonly used methods and tools, sharing resources, collaborations, facilitating relevant mentoring and training, pilot projects, community engagement, and disseminating research findings. Proposed evaluation metrics to monitor the progress and successes of the Core should be included in the application. Project Budget and Subaward Mechanism(s) New awards support a total budget of $1.

65 M ($1. 5 M direct costs plus 10% indirect costs) for a 4-year project period to include one research subaward and CHERC Supportive Core activities. There is no designated budget cap for the CHERC Supportive Core, but all activities must be fully described in the budget justification.

Research subawards include the following ACS research grant mechanisms: Clinician Scientist Development Grants (CSDGs) provide support for protected time to allow faculty who are involved with patient care to be mentored and participate in research training to aid their development as independent clinician scientists. Faculty already serving as PI of an independent research program may not apply for a CSDG.

Applicants serving as the PI (current or former) of independent extramural research grants that are more than 1 year duration AND more than $100k total direct costs, including multi-PI awards, are not eligible to apply. CSDG applicants can propose 3-, 4-, or 5-year projects, at $135,000 direct costs per year and 8% indirect costs.

Research Scholar Grants (RSGs) provide support to independent, self-directed researchers for 4 years at $215,000 per year direct costs and 10% indirect costs. To be eligible, RSG subaward PIs must have a full-time faculty position and a doctoral degree. For this RFA, faculty may have any rank.

Note: As of 2025, individual postdoctoral fellowships are no longer included as part of this award, but postdocs are encouraged to apply through our standard PF mechanism. Postdoctoral fellows may be included in the Center or the subaward budgets as personnel. AI Based Application Success Predictor 🔑 1.

High-Impact, Hypothesis-Driven Science (Most Critical) ACS reviewers prioritize: Clear, testable hypothesis (not exploratory only) Strong biological or population-science rationale Innovation that meaningfully advances the field 👉 Weak hypothesis = one of the most common rejection reasons 🎯 2.

Direct Relevance to Cancer Burden Funded proposals clearly address: Cancer risk, prevention, detection, treatment, or survivorship Or major contributors (e.g., tobacco, obesity, disparities) 👉 ACS is mission-driven: “How does this reduce cancer burden? ” must be obvious 🌍 3.

Population-Level or Patient-Level Impact Public health impact (very strong weight) Behavioral, epidemiological, or implementation research Interventions that can scale More weight on real-world impact , not just biology ⚖️ 4. Balance Between Innovation & Feasibility Are innovative but not overly risky 👉 Over-ambitious = frequent rejection 👩‍🔬 5.

Investigator Potential (Key Differentiator) ACS strongly funds people, not just projects : Clear trajectory toward independence Established investigators: Productivity (publications, prior grants) 👉 Weak CV can sink even a good idea 🧪 6. Rigorous Study Design Clearly defined aims (usually 2–4) Appropriate methodology and statistics Feasible recruitment/sample access 👉 Vague methods = major scoring penalty 🤝 7.

Alignment with ACS Priority Areas Higher success rates seen in: Cancer disparities research Prevention (lifestyle, screening) Survivorship and quality of life 👉 These areas are often strategically prioritized 🏥 8. Strong Institutional & Mentorship Support Clear institutional backing 👉 Especially critical for fellowships and junior awards 💰 9.

Realistic Budget & Scope Budget matches project scale 👉 Over-scoped proposals often fail feasibility review 📑 10.

Clear, Reviewer-Friendly Writing Are easy to read and logically structured Hypothesis → Methods → Impact 👉 Poor presentation can undermine strong science 📊 What Actually Wins (Practical Ranking) Strong hypothesis + innovation Real-world or population impact ⚖️ Major differentiators: Feasible, rigorous design Alignment with ACS priorities Compared with other cancer funders: American Cancer Society = “impact-balanced science” Not as biology-heavy as AACR Not as purely clinical as ASCO 👉 The winning formula is: Strong science + clear path to reducing cancer burden (especially at population level) All applicants must be independent researchers at eligible US academic institutions or non-profits.

Applicants from underrepresented groups and from Minority Serving Institutions (MSIs) are encouraged to apply. Previous CHERC awardees may submit applications for competitive renewals of the CHERC Supportive Core only.

The Center's PI must have a strong track record of addressing cancer health disparities as evidenced by extramural cancer research funding, mentoring junior investigators, publications in peer-reviewed journals, and administrative/leadership experience. Sponsor Institute/Organizations: American Cancer Society Sponsor Type: Corporate/Non-Profit Address: P. O.

Box 6704. Hagerstown, MD 21741 Legal & Affiliation Disclaimer Accuracy and Verification Disclaimer: Trialect makes no warranties regarding the accuracy, completeness, or reliability of the information provided by sponsors. Users are advised to verify the details of any funding opportunity directly with the sponsor before taking action.

Trialect cannot be held liable for any discrepancies, omissions, or inaccuracies in third-party postings. Affiliation: American Cancer Society Address: P. O.

Box 6704. Hagerstown, MD 21741 Website URL: https://www. cancer.

org/research/we-fund-cancer-research/apply-research-grant/grant-types/rfa-cancer-health-research-centers. html Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www. protrip-world-liability.

com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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