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SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) is sponsored by U.S. Department of Health and Human Services (HHS) / National Institutes of Health (NIH). The SBIR/STTR Commercialization Readiness Pilot Program provides funding to small businesses for late-stage research and development activities not typically supported through Phase II awards, but are needed for successful commercialization.
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Opportunity Listing - SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders 93. 837 -- Cardiovascular Diseases Research 93.
859 -- Biomedical Research and Research Training 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93. 838 -- Lung Diseases Research 93.
839 -- Blood Diseases and Resources Research 93. 865 -- Child Health and Human Development Extramural Research 93. 172 -- Human Genome Research 93.
233 -- National Center on Sleep Disorders Research 93. 143 -- NIEHS Superfund Hazardous Substances_Basic Research and Education 93. 351 -- Research Infrastructure Programs 93.
307 -- Minority Health and Health Disparities Research 93. 273 -- Alcohol Research Programs 93. 840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93.
394 -- Cancer Detection and Diagnosis Research 93. 855 -- Allergy and Infectious Diseases Research 93. 846 -- Arthritis, Musculoskeletal and Skin Diseases Research 93.
350 -- National Center for Advancing Translational Sciences 93. 113 -- Environmental Health 93. 121 -- Oral Diseases and Disorders Research 93.
286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health 93. 242 -- Mental Health Research Grants 93. 173 -- Research Related to Deafness and Communication Disorders 93.
395 -- Cancer Treatment Research 93. 313 -- NIH Office of Research on Women's Health 93. 393 -- Cancer Cause and Prevention Research 93.
867 -- Vision Research Last Updated: June 1, 2026 View version history on Grants. gov The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support.
This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.
Independent school districts Private institutions of higher education Public and state institutions of higher education City or township governments Federally recognized Native American tribal governments Special district governments Public and Indian housing authorities Nonprofits non-higher education without 501(c)(3) Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) For-profit organizations other than small businesses Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.
gov/apply) are eligible to submit applications for this opportunity. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.
Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Grantor contact information NIH SEED (Small business Education and Entrepreneurial Development) NIH SEED (Small business Education and Entrepreneurial Development) File name Description Last updated PAR-27-098-Revised-Full-Announcement. html PAR-27-098-Revised-Full-Announcement.
html Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Small businesses that have previously received SBIR or STTR awards. Confirm the full requirements in the official notice before applying.
SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) is funded by U.S. Department of Health and Human Services (HHS) / National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) is sponsored by U.S. Department of Health and Human Services (HHS) / National Institutes of Health (NIH). The NIH STTR program expands funding opportunities in the federal innovation research and development arena, requiring a partnership between a small business and a non-profit research institution.
NIH-led Bio Genesis Mission is sponsored by U.S. Department of Health and Human Services (HHS) / National Institutes of Health (NIH). A government-wide effort that will use artificial intelligence, advanced computing, and cross-sector partnerships to modernize the biomedical research ecosystem and cut in half the time it takes for scientific discoveries to reach patients.
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