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SBIR/STTR Phase I is a grant from the National Cancer Institute (NCI) that funds small businesses developing innovative technologies and solutions with potential to advance cancer research, detection, and treatment. The SBIR program supports small businesses, while STTR requires a partnership with a nonprofit research institution.
Phase I awards typically range from $150,000 to $250,000 and fund feasibility studies for proposed innovations. Note: As of October 1, 2025, NIH's legislative authority for SBIR/STTR programs expired; current recipients should contact their Program Officer. Eligible applicants are small businesses meeting SBA size standards.
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SBIR Application Process & Resources - NCI NIH has no active Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) solicitations because the legislative authority for the programs expired on October 1, 2025. Current recipients should direct any questions to their Program Officer. See NOT-OD-26-006 .
Small Business Application Process and Resources This page features resources to help small businesses apply for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding.
SBIR/STTR Application Basics Omnibus Solicitation and other grant opportunities follow the NIH Standard Receipt Dates for SBIR and STTR (September 5, January 5, April 5) SF424 SBIR/STTR Application Guide for NIH and Other PHS Agencies (Forms I) Annotated Form Set for NIH Small Business (SBIR/STTR) Grant Applications (Forms H) Using NIH ASSIST to help submit your grant application Talk to our program directors before you start your preparation!
Who is Eligible for SBIR/STTR Funding? The NCI's SBIR/STTR funding is for small businesses based in the United States. Companies must meet eligibility criteria.
Status : Applicant must be a for-profit US small business. Location : Applicant must be based in the US, with work performed in the US. Size : Applicant must have 500 or fewer employees, including affiliates.
Ownership : >50% owned by U.S. individuals and independently operated OR >50% owned and controlled by another (one) business concern that is >50% owned and controlled by one or more individuals OR >50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these (SBIR only) SBIR/STTR Sample Applications Funded Company Application Type Technology Type Application Links ISPIN, Inc. Small Business Innovation Research Grant (SBIR) Digital Health R43 (Forms-D) Specific Aims page Courier Therapeutics, Inc. Small Business Technology Transfer Grant (STTR) Drug Discovery and Development R41 (Forms-D) Specific Aims page Enspectra Health, Inc. Phase IIB Bridge Award Medical Device R44 (Forms-F) Specific Aims page Stingray Therapeutics, Inc. Direct to Phase II (SBIR Only) Therapeutics R44 (Forms-G) NIH SBIR/STTR Application Processes —Learn about the National Institutes of Health (NIH) SBIR/STTR funding application processes.
NIH Grant Processes —Learn about the steps required for an application to proceed from planning and submission through to award and closeout. NIH SBIR/STTR Just-in-Time Procedures —The Just-in-Time feature of the eRA Commons allows a signing official to electronically submit additional grant application information that is requested by the grantor agency after the completion of the peer review and prior to funding.
NIH ASSIST —The Application Submission System & Interface for Submission Tracking (ASSIST) system is used to prepare and submit grant applications electronically to NIH. NCI Resources for Researchers —Find NCI-supported tools and services for cancer researchers. NIH Matchmaker —Use this site to conduct keyword searches on particular topic areas to identify NIH Institutes and Centers that have previously funded research in that area.
NIH RePORTER —Find previously funded projects through this site. Agency and State Contacts: Information about Incubators, Business Development Centers, Bio Life Science Centers, and State Commercialization Organizations Life Sciences Resources by State [HA1] Find the Small Business Association’s Local Assistance
According to the current listing, eligibility includes: Small businesses (SBIR) or small businesses partnering with research institutions (STTR). Confirm the full requirements in the official notice before applying.
The current listing shows $150,000 - $250,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
This listing does not include a published deadline, but it is an annual program. Check the official notice for the current cycle's exact dates.
SBIR/STTR Phase I is funded by National Cancer Institute. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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