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Scientific Instrumentation for Sensing and Imaging (NSF X-Labs initiative) is sponsored by U.S. National Science Foundation (NSF). The NSF X-Labs initiative invites proposals for independent teams of researchers, engineers, and entrepreneurs to build the next generation of scientific instruments, drawing on quantum sensing, artificial intelligence-driven computational imaging, and entirely new chemical moda…
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NSF announces $1. 5B NSF X-Labs initiative to pursue generational breakthrough science efforts | NSF - U.S. National Science Foundation NSF announces $1.
5B NSF X-Labs initiative to pursue generational breakthrough science efforts NSF X-Labs will scale a new generation of transformative independent research organizations to advance breakthrough science outside of traditional institutions Today, the U.S. National Science Foundation announced $1.
5 billion over the next decade toward the NSF X-Labs initiative to tackle pressing scientific challenges through novel and innovative research partnerships. This substantial long-term investment underscores NSF's commitment to new models of research outside of traditional institutions, reflecting the truly interdisciplinary nature of today's modern science ecosystem.
NSF X-Labs are independent teams of researchers, engineers and entrepreneurs pursuing milestone-based federal funding to solve specific scientific challenges. Scientific Instrumentation for Sensing and Imaging — NSF is seeking X-Labs to build the next generation of scientific instruments, drawing on quantum sensing, artificial intelligence-driven computational imaging and entirely new chemical modalities.
Quantum Systems: Interconnects and Integrated Photonics — NSF is seeking X-Labs to develop novel components to transfer quantum information and integrate heterogeneous quantum systems — key enablers of the computing frontier beyond classical systems.
The NSF X-Labs initiative is guided by the ambition of President Donald Trump's mandate to revitalize and strengthen America's science and technology ecosystem by exploring innovative models for funding and sharing high-value scientific research infrastructure and results.
The design choices underpinning these efforts are informed by thoughtful science policy scholarship and entrepreneurship from both emerging and established think tanks, metascience experts, congressionally chartered study commissions and the broader scientific community.
"The NSF X-Labs initiative represents our ambitious commitment to meeting the needs of the scientific enterprise today and tomorrow," said Brian Stone, performing the duties of the NSF director. "With an initial investment of up to $1.
5 billion in independent, milestone-driven research teams pursuing sector-defining platform capabilities, we're creating the conditions for transformative breakthroughs and accelerating America's leadership in the technologies that will define this century." "NSF X-Labs represent a bold step forward in revitalizing American innovation, consistent with our goal of expanding possibilities for American scientists.
I encourage all federal research agencies to follow suit. By backing a new generation of independent research organizations, we are giving entrepreneurial teams of scientists and engineers the autonomy, resources and milestone-driven focus to tackle challenges that were difficult to pursue in conventional academic and industry labs, opening brand new lines of inquiry.
This is how we build the scientific institutions of the 21st century and secure our technological leadership for decades to come," said Michael Kratsios, assistant to the president and director of the White House Office of Science and Technology Policy.
NSF X-Labs, initially previewed during the early design stages as Tech Labs , was launched through a request for information (RFI) in December 2025 , grounded in the recognition that many of today's science and technology acceleration and translation challenges require new approaches with coordinated, interdisciplinary teams to succeed.
NSF X-Labs will move beyond traditional research outputs (e.g., publications and datasets), with sufficient resources, financial runway and independence to transition critical technology from early concepts or prototypes to commercially viable platforms ready for private investment to scale and deploy.
To help shape the initiative and inform the program's initial topics, the NSF Directorate for Technology, Innovation and Partnerships (NSF TIP) invited input from the broader community through an RFI. In response, NSF TIP received constructive feedback and has used that input to inform this first funding opportunity. TIP will further consider how to incorporate feedback from the RFI into future opportunities.
To learn more about the initiative and how to apply, read the NSF X-Labs funding opportunity and topic announcements and plan to join an introductory webinar. You must register online to join the webinar. Directorate for Technology, Innovation and Partnerships (TIP)
According to the current listing, eligibility includes: Independent teams of researchers, engineers, and entrepreneurs. Confirm the full requirements in the official notice before applying.
Scientific Instrumentation for Sensing and Imaging (NSF X-Labs initiative) is funded by U.S. National Science Foundation (NSF). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Summary: The fiscal year 2026 (FY26) Duchenne Muscular Dystrophy Research Program (DMDRP) Idea Development Award (IDA) promotes new ideas that are still in the early stages of development and have the potential to yield impactful data and new avenues of investigation. This award supports impactful, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress in improving outcomes for individuals with Duchenne muscular dystrophy (DMD) in the near term. Applications should include a well-formulated, testable hypothesis based on strong scientific rationale. The DMDRP strongly encourages research projects investigating therapies designed to demonstrate efficacy cross the life span, including infants, toddlers and nonambulatory individuals.Distinctive Features: The FY26 DMDRP IDA mechanism offers three eligibility career categories:• The Established Investigator category is for independent investigators at all academic levels, or equivalent• The New Investigator – Early-Stage category is for independent investigators early in their careers (i.e., within 10 years of their first faculty appointment or equivalent). Applicants in this category will be reviewed separately from Established Investigators.• The New Investigator – Transitioning category is for independent investigators at all academic levels, or equivalent, in an area other than muscular dystrophy who are seeking to transition to a career in DMD, thereby bringing their expertise to the field. Applicants in this category will be reviewed separately from Established Investigators.Preliminary data relevant to DMD that supports the feasibility of the research hypotheses and research approaches are required for all applications. Clinical trials or clinical trial aims are not allowed. Funding Opportunity Number: HT942526DMDRPIDA. Assistance Listing: 12.420. Funding Instrument: G. Category: ST. Award Amount: $2.5M total program funding.
Research Infrastructure Programs - Research Centers is sponsored by Department of Health And Human Services. The Office of Research Infrastructure Programs (ORIP), within the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) in the NIH Office of the Director, supports extramural biomedical research by strengthening the infrastructure that enables scientific discovery. ORIP advances human health by fostering the development of critical research models, biomaterials, and technologies; expanding access to state-of-the-art instrumentation and facilities; supporting education and training programs; and assisting small businesses in translating innovative technologies. Through its two divisions, the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI), ORIP plays a critical role in accelerating biomedical research nationwide. DCM develops and sustains essential research models and biological resources, manages the infrastructure required for their use and distribution, and provides training to ensure investigators have reliable access to high-quality models and facilities. DCI supports shared, cost-effective access to advanced scientific instrumentation, modernizing research facilities, and providing critical equipment that enables transformative biomedical discoveries. Together, DCM and DCI strengthen U.S. competitiveness and ensure the biomedical research community has the infrastructure necessary to address emerging health challenges, prevent disease, promote health, and advance foundational science. This listing is currently active. Program number: 93.3RC. Last updated on 2026-01-28.
TCUP lists eight funding tracks and roughly $10.3M a year, but the October 14, 2026 deadline applies to only three of them — CHAI, Pre-TI, and TCUP Partnerships — and each carries a restriction that disqualifies most applicants. Here is the track-by-track math.
Read articleNSF 26-513 makes roughly $100 million available for up to 10 State and Regional AI Infrastructure Hubs at $4M to $12M each over five years. One award per state or multi-state region. One proposal per organization. And NSF is not buying you GPUs — it funds the coordination, the workforce and the faculty training, while the compute has to come from partners you have to already have.
Read articleAs of September 12, NSF had obligated $6.3 billion across 6,200 grants versus $8.1 billion and 8,600 last year. AHRQ has made 61 awards. Judge Allison Burroughs ordered the government to report by September 28 on whether IES will obligate $180 million before it expires. Here is what actually happens to the money on October 1 — and what it means for your FY2027 application.
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