Seed Instrumentation Support (SIS) Program (PAR-27-021)

Seed Instrumentation Support (SIS) Program (PAR-27-021) is sponsored by National Institutes of Health (NIH). Supports the purchase of equipment to enhance biomedical research capabilities.

PAR-27-021: Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed) Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs ( ORIP ) National Institute of Allergy and Infectious Diseases ( NIAID ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers. Office of Data Science Strategy ( ODSS ) Funding Opportunity Title Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed) S10 Biomedical Research Support Shared Instrumentation Grants Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON) Companion Funding Opportunity Biomedical Research Support Shared Instrumentation Grants See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93. 351, 93. 855, 93.

310, 93. 866 Funding Opportunity Purpose This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution.

Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.

Funding Opportunity Goal(s) The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).

Open Date (Earliest Submission Date) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Use Grants. gov Workspace to prepare and submit your application and eRA Commons to track your application.

Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Through the Seed Instrumentation Support (SIS) Program, NIH supports the purchase of a single commercialized research instrument that is currently unavailable to the applicant institutions.

Like a seed, the instruments are expected to help promote new research opportunities, expand existing research capabilities, foster collaboration and training, and support the growth of future research activities. Modern research instruments are essential for generating high quality and reproducible data that drive innovations in biomedical and biobehavioral research in all institutions, including low-resource ones.

Instruments funded through this program will be shared among users to promote cost-effective research for reproducible biomedical data generation. Hence, the instrument is expected to be placed in a safe and accessible shared resource to maximize collaboration.

This NOFO encourages different outcomes based on institutional type: (i) For research-intensive institutions, emphasis is placed on acquiring new or emerging technologies that enable innovative and novel research; and (ii) For low-resource institutions (e.g., R15-eligible institutions that have not received more than $6 million per year in NIH funding in 4 of the last 7 federal fiscal years), the focus is on building foundational research capacity, expanding the biomedical research workforce, and supporting sustainable, long-term research programs.

Institutions applying under this category will clearly justify their low-resource status in the application. Eligible instruments include, but are not limited to, mass spectrometers, cell sorters, bioimagers, DNA and protein sequencers, light microscopes, 3D printers, and high-performance computers.

Applications for general purpose computer systems (computer clusters and data storage systems) will only be considered if the system is solely dedicated to biomedical research. Foreign-made instruments are allowed. However, the reasons for choosing foreign-made instruments over domestically manufactured instruments will be justified.

NIH urges that every effort should be made to give preference to domestically manufactured instruments to the maximum extent possible. Additionally, requesting funds towards purchasing an instrument under a lease agreement is strongly discouraged.

Program Director/Principal Investigator (PD/PI): Each applicant institution will propose a PD/PI who can assume administrative and scientific oversight responsibility for the requested instrument. The PD/PI will also be responsible for: Preparing (and working with the institution to submit) a Final Research Performance Progress Report (Final RPPR) at the end of the project budget period. See Section VI.

4 for the content of a Final RPPR. Preparing and submitting Annual Usage Reports (AURs) of the instrument to the NIH for a period of four years after the project end date, see Section VI. 4.

Requesting no-cost extensions of the project period, if needed. Advisory Committee: An Advisory Committee will be named to assist the PD/PI in administering the grant, overseeing the usage of the instrument, and advising on expanding the user base.

The PD/PI and the Advisory Committee should convene regular meetings and issue annual reports on the instrument status, including their recommendations for the instrument operations and plans for a growing user base. For details on the composition of the Advisory Committee, see Section IV. 2 under "Administration."

The PD/PI and the Advisory Committee are responsible for the development of guidelines for: A plan for the management and safe operation of the instrument. A plan to ensure that access to the instrument is limited to users whose projects have received approval from the Institutional Review Board, the Institutional Animal Care and Use Committee or a Biosafety Committee, as applicable.

A financial plan for the long-term operation and maintenance of the instrument. Recommending a new PD/PI, if such a need arises. A relocation of the instrument within or outside the institution or change(s) of ownership, if such changes are necessary.

Applications Not Responsive to this NOFO The following types of applications are not responsive to this NOFO and will not be reviewed: Instruments or integrated systems that are not commercially available and do not have a manufacturer's warranty. More than one stand-alone workstation for data processing, multiple software licenses, and duplicate software items.

Software, unless it is integrated in the operation of the instrument and/or necessary for generation of high-quality experimental data from the instrument.

Research equipment to furnish a research facility (such as autoclaves, hoods, equipment to upgrade research facilities) or general-purpose equipment (such as standard machine shop equipment), equipment for routine sustaining infrastructure (such as standard computer networks or general-purpose data storage systems). Purely instructional equipment. Disposable devices, office furniture, and supplies.

Alteration or renovation of space to house the instruments. Applications proposing such requests will be considered non-responsive and will not be reviewed or considered for funding. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO. Not Allowed: Only accepting applications that do not propose clinical trials.

Note: Applications may propose activities involving human subjects that are not deemed clinical trials. Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Applications will be accepted that request a single, commercially available instrument. The minimum award is $50,000. There is no upper limit on the cost of the instrument, but the maximum award is $400,000.

S10 awards do not allow indirect costs. Awards are made for one year only. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III.

Eligibility Information Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Foreign Organizations/Foreign Collaborations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM.

Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM. gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.

Grants. gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role.

Obtaining an eRA Commons account can take up to 2 weeks. All PD(s)/PI(s) must be registered with ORCID . The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID.

For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help .

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms.

3. Additional Information on Eligibility Applicant organizations may submit only one application, provided that the type of instrument does not currently exist in the applicant organization (identified by UEI). The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Minimal User Requirement: A minimum of two NIH-funded users must be identified, with at least one of the NIH-funded users must be from the applicant institution. NIH-funded users from other institutions are highly encouraged.

Each of the NIH funded users must be a PD/PI on a distinct active NIH award (i.e., a grant or a cooperative agreement). An award given to multi-PDs/PIs is counted only once towards the fulfillment of this requirement. Users with funding from sources such as other Federal agencies, private foundations, or academic institutions are eligible to use the instrument.

To justify the requested instrument, the projects supported by NIH research awards should together have a preponderant use of the instrument. While training, curricular instructions, or other non-biomedical research activities may be supported by the instrument, for-profit activities or billable clinical care are not allowed to use the instrument.

Note: The SIS S10 Program is intended to promote innovation and foster sustainable research programs at applicant institutions. Institutions that focus primarily on development rather than research or short-term awards, such as an SBIR/STTR grant, do not directly align with the goal of developing a sustainable research program and may be incompatible or less competitive for this program.

Quote: An itemized quote from the vendor with appropriate academic discounts and warranty terms (specified directly in the quote) is required and must be included in the application. Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice , or other notice from NIH Guide for Grants and Contracts ).

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

For this NOFO, the following specified page limits for each section of the Instrumentation Plan apply as described below. All tables, graphs, figures, diagrams, and charts must be included within the page limits for these sections. The applicants should make every effort to be succinct.

It is expected that the length of the Instrumentation Plan's narrative will depend on the type of the requested instrument and the number of users. To be successful, an application does not have to reach the page limits: Introduction to Resubmission (if applicable): 1 page. Justification of Need: 2 pages in total.

Technical Expertise: 1 page. Research Projects: Including a Summary Table, must not exceed 3 pages in total. Administration (Organizational/Management Plan): 2 pages.

Institutional Commitment: 1 page. Overall Impact/Benefit: 1 page. Note: Letters of Support and Bibliography & References Cited Section are not included in the page limitations.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the How to Apply - Application Guide must be followed. Descriptive Title : Enter the generic name of the instrument requested in the title (for example, Spinning Disk Confocal Microscope).

Proposed Project : CY 2026 submission: enter start date 05/01/2027 and end date 04/30/2028; CY 2027 submission: enter start date 05/01/2028 and end date 04/30/2029; CY 2028 submission: enter start date 05/01/2029 and end date 04/30/2030. Estimated Project Funding : Total Federal Funds Requested : Enter the total Federal funds for the requested instrument. This entry cannot exceed $400,000 which is the maximum award under the Program.

If the cost of the instrument is more than $400,000, enter $400,000. Total Non-Federal Funds : If Total Federal Funds Requested (described immediately above) and Total Federal & Non-Federal Funds (described immediately below) are not the same, enter the difference in this line. Explain how the difference will be paid in the Equipment section on the SF424 (R&R) Other Project Information form (described below).

Total Federal & Non-Federal Funds : Enter the total cost of the instrument from the quote. Program Income : Enter zero as this does not apply to the Program. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Other Project Information All instructions in the How to Apply - Application Guide must be followed. For specific instructions, please visit the ORIP S10 FAQ page at https://orip. nih.

gov/division-construction-instruments/s10-instrumentation-programs/frequently-asked-questions . Project Summary/Abstract : The Project Summary/Abstract should contain a succinct and accurate description of the requested instrument and an explanation of the need for the instrument to advance research projects of the Users.

The application's broad, long-term objectives should be stated, concisely describing how access to the instrument will support the research projects. Project Narrative : Using no more than three sentences of plain language, describe the relevance of this research to public health.

Bibliography & References Cited : List only publications that demonstrate the researchers' expertise in operation and usage of the requested instrument or that are relevant to research projects which will be supported by the instrument. References to the Research Projects Section may appear in this section or may be listed at the end of individual research subsections. Facilities & Other Resources : Not Applicable.

Do not include an attachment here. Equipment : Describe the requested instrument by stating its manufacturer, model number, specific features, and accessories. Provide a detailed budget breakdown of the main instrument and requested accessories, including tax and import duties (tariffs), if applicable.

An itemized quote from the vendor, with appropriate discounts and warranty terms, is required. The quote must be unaltered and combined in a single attachment with the equipment description as part of this upload. As described above in SF424 Cover form, include an explanation of Total Non-Federal Funds in this section (if applicable).

Applications without a valid quote will be deemed incomplete and will be withdrawn from review. If human, animal, or infectious materials, which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instrument may be requested in the budget.

Do not describe the need for the instrument or accessories in this section; such narrative should be a part of the Justification of Need section of the Instrumentation Plan. I) Instrumentation Plan (in lieu of Research Plan form) The entire Instrumentation Plan (with the sections described below) must be saved as a single PDF file - named Instrumentation Plan - and attached via Other Attachments.

Organize the sections of the Instrumentation Plan in the specified order as described below, starting each section with the appropriate section heading (i.e., Justification of Need, Technical Expertise, Research Projects, etc.). Do not include links to websites for further information. Do not include animations/videos.

Introduction : Only in the case of a resubmission, include an Introduction describing the changes that have been made in response to comments in the previous review. Justification of Need : Name the requested instrument. Compare the performance of the requested model with other similar instruments available on the market.

Justify the need for specific model, features, and special accessories of the requested instrument. Explain how the acquisition of this instrument will act as a catalyst for new research directions/programs, help create new research opportunities, develop expertise, grow research capacities, and expand research activities for long-term success. Justify the need for software, if applicable.

Software supported by this program must be critical to the operation of the instrument or necessary for generation of high-quality data. Stand-alone workstations, duplicate software items, and software licenses are not allowed. Preliminary data is not required, though if access to a demo instrument is practical, it can be included to justify the choice of the instrument.

Requesting instruments under a lease agreement is strongly discouraged, consulting the Scientific/Research contact is strongly recommended. Technical Expertise : Describe the technical expertise of individuals who will set up and run the instrument. Specify who will ensure that the instrument is safely operated and appropriately maintained.

State training plan, who and how will train new users. If the instrument requires complex sample preparation or consultation for experimental designs, describe the expert individuals who will serve in that capacity. Address technical support for data collection, management, and analysis.

If an innovative instrument providing new research capabilities is requested, demonstrate the special technical expertise needed for increasing its adoption in biomedical research. Describe training for the investigators on using the novel technology to advance their research. Research Projects : The Research Projects section should focus on explanation of how the requested instrument will advance research projects.

In this section, describe the benefits of the requested instrument to enhance the users' research projects. Since the research projects have been previously peer-reviewed, their details should be described succinctly and clearly, and only as necessary to explain how the requested instrument will advance the projects' research objectives. The recommendation is 1 or more Major User's projects per page.

The descriptions of other users' projects are expected to be succinct (several projects per page). Summary Tables : State the annual usage hours, as introduced in the Justification of Need Section.

Next, insert the following columns into the summary tables (a sample summary table is available at ORIP S10 FAQ page ): User's name, grant number (for NIH awards, list the grant numbers such as R01CA123456), brief title of the project, grant start and end dates, and estimated usage in annual hours.

If there are multiple users funded by the same grant, list the total of their estimated usage in annual hours for projects supported by that grant. Following the tables, state the total estimated usage time by all users' projects in annual hours, and the percentage of the estimated usage time devoted to all NIH-funded projects. Administration (Organizational/Management Plan): Describe the organizational plan to administer the grant.

Describe where the instrument will be located, how it will be utilized, how requests to use the instrument will be made, how time will be allocated among users, how other projects and new users will be enlisted. Describe how expertise will be sustained and users will be trained in experimental design, instrument operation and data analysis. Describe typical day-by-day management of the instrument.

If the plans are to install the instrument in a setting other than a core or a shared resource facility, describe the procedures that will implement and assure broad access to the instrument and its use on a shared basis. List the names and titles of the members of the local Advisory Committee.

The membership of this Committee should represent the interests of different users and should include non-user members to avoid conflicts of interest who can resolve disputes if they arise. The membership of this Committee should include at least one senior institutional official who will represent the financial commitment of the institution. It is recommended that the Advisory Committee includes at least 4 members.

The PD/PI cannot serve as the Chairperson or a voting member of the Committee. Users of the instrument may be members, but none should be the Chairperson. The PD/PI and the Advisory Committee should convene meetings and prepare annual reports on the instrument status.

The reports will become part of the Final Research Performance Progress Report (Final RPPR) and the Annual Usage Reports (AUR) (see Section VI. 4). Provide a plan about how the Users will be instructed and reminded about citing the S10 award in their publications and how their compliance will be verified.

Describe a plan for managing access to the instrument if users' projects involve human subjects, vertebrate animals, or biohazards such as infectious materials. Financial Plan: Submit a specific financial plan for the long-term operation and maintenance of the instrument as such costs are not supported by the S10 Program.

Explain how various operational costs will be met; specifically, costs associated with routine operation and maintenance of the instrument, and costs for support personnel. Enumerate the sources of income such as charge back fee structure, grants, or institutional support. The financial plan must include a table for years 1-5 of operation.

For year 1, although the maintenance costs are fully covered by a one-year manufacturer warranty, enter anticipated expenditures and anticipated income, showing how these estimates were derived. For years 2-5, approximate amounts, based on data for year 1, must be considered in the financial plan. A description of projected changes to the financial plan over the four years is also needed.

Operation: Include salary support of expert personnel that will operate the instrument and oversee routine care and procedures for standardization. Maintenance: May include a service contract, or funds for parts and local technical personnel who will maintain the instrument (if such personnel are qualified to do so).

Supplies: Include necessary supplies for operating the instrument such as chemicals, cryogenics, and other expendable items. Software: Include costs for updates/maintenance of software licenses needed for the proper operation of the instrument or additional software for data analysis. Anticipated Income: Enumerate the sources of income, such as any charge back fee structure, grants, or institutional support.

Institutional Commitment : Describe the institutional infrastructure available to support the instrumentation and grow sustainable research activities, including space to house the instrument and site for sample preparation, if applicable. Confirm the institutional support toward the maintenance and operation of the instrument for five years from the installation date of the instrument or for its effective lifetime.

Describe institutional support for personnel. The timeline of institutional support should be consistent with the expected usable lifetime of the type of requested instrument. Overall Impact/Benefit : Explain how the instrument will impact NIH-funded research and contribute to the institution's long-range biomedical research goals.

All letters of support should be combined into a single file named Letters of Support and uploaded as a separate attachment via Other Attachments. This combined file should include, as applicable: Letters from institutional officials, confirming the requested instrument is not available to the institution. Institutional commitment to the proposed financial plan for maintenance and operations.

Letter from Biosafety Official. If human, animal, or infectious materials, which could create a potential biohazard, are to be analyzed, a signed letter from the institutional biosafety officer is required. The letter should state that the proposed containment plan has been reviewed and adheres to documented biosafety regulations.

SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply - Application Guide must be followed. Include the profiles of the PD/PI, users, and technical personnel, as applicable. All instructions in the How to Apply - Application Guide must be followed.

All instructions in the How to Apply - Application Guide must be followed. PHS 398 Cover Page Supplement All instructions in the How to Apply - Application Guide must be followed.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide .

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: A Data Management and Sharing Plan is not applicable for this NOFO. Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide .

No publications or other material, with the exception of blank