Single-Cell Biology Data Insights is sponsored by Chan Zuckerberg Initiative. This grant program seeks to support computational experts to advance tools and resources that make it possible to gain greater insights into health and disease from single-cell biology datasets.

Single-Cell Biology Data Insights RFA | CZI Science This RFA closed on December 5, 2023 The Chan Zuckerberg Initiative invites applications for the third of three cycles for 18-month projects focused on advancing tools and resources that make it possible to gain greater insights into health and disease from single-cell biology datasets. Learn about our grantees from Cycle 1 and view the RFA .

Learn about our grantees from Cycle 2 and view the RFA . Learn about our grantees from Cycle 3 and view the RFA. For administrative and programmatic inquiries, or other questions pertaining to this RFA, please contact sciencegrants@chanzuckerberg.

com . We invite applications for consideration for funding during three distinct cycles: Cycle 3 Application opening date Cycle 3 Applications due by 5 p. m.

Pacific Time Cycle 3 Earliest notification of decisions (subject to change) Cycle 3 Earliest start date (subject to change) Award period and start date: Proposed projects should be 18 months; expected start date for awards in Cycle 3 is August 1, 2024. Institutional Approval Form The Chan Zuckerberg Initiative (CZI) seeks to support projects that will advance the fields of single-cell biology and data science.

Grantees will be expected to interact with existing groups to build community and accelerate progress. Applications are encouraged from computational experts outside the field of single-cell biology, but with expertise relevant to overcoming current bottlenecks and driving discoveries in the single-cell biology field.

Projects may include: dedicated efforts to democratize access and usability of existing datasets; demonstration of utility by leveraging existing datasets to address impactful and challenging biological questions; and developing methods that enable greater biological insight and other major challenges brought forward.

This request for applications is the last of three currently planned cycles, with successful projects receiving 18 months of funding support. Applications for two types of grants are welcome and will be reviewed independently. The maximum budgets for proposed projects are $400,000 total costs for Expanded Projects and $200,000 total costs for Focused Projects .

All project awards will be for an 18-month duration. The goal of this opportunity is to create a network of projects that address broad computational challenges and needs within single-cell biology at a variety of scales. Applicants may highlight existing or prospective collaboration among projects, but should note that all applications will be reviewed for their individual merit and impact.

Single-cell biology has undergone rapid growth over the last five years, with a recent increase in the volume of available and openly accessible datasets and cell atlases, including the release of the 37+ million cells CZ CELLxGENE Discover Census .

This funding opportunity is specifically intended to motivate and incentivize the development, refinement, and implementation of approaches that make it possible for greater insights to be gained from available single-cell data. With this in mind, any form of data generation is considered out of scope.

Projects must propose and rely on existing data that is openly and freely available (count matrices at minimum) at the time of application via the inclusion of a link to specific datasets in the applications. Furthermore, we strongly encourage applications to use data generated outside of their labs to enable interoperability and advances that are extensible to a wider segment of interested researchers.

Addressing computational challenges and bottlenecks in single-cell biology will drive the field forward and make it possible for a greater number of scientists to benefit from emerging datasets and tissue atlases. This opportunity puts forward a broad scope that fundamentally aims to enable greater insight into specific biological questions to be gleaned from single-cell data.

Successful proposals are likely to incorporate some or multiple of the following attributes: Meta-analysis of single-cell datasets or collections, such as available via CZ CELLxGENE Discover Census, that highlights its characteristics, usability, and utility and enables insight into more specific biological questions and unlock mysteries of the cell and how cells interact in systems.

Address specific challenges, such as predicting cellular responses to perturbations, modeling regulatory networks, understanding evolutionary differences at the cellular level or cellular basis of traits and diseases, system-level delineation of lineage establishment, or deciphering cell-cell interactions and spatial organization. Democratize access and usability of existing datasets.

For example, the development of subsampling approaches or scalable and accessible models for data representation (embeddings), querying, and downstream tasks of broad interest. Applications of AI and machine learning to open problems in single-cell biology with a possible focus on infusing domain knowledge in a model and experimental design and development of novel training paradigms or model evaluation strategies.

Connecting data across scales and modalities. Using data from underrepresented ancestries or populations. It is also an explicit goal of this effort to build a community among international participants that encourages collaboration and coordination, and we envision that the overlap between funding cycles will allow continuity and learning.

CZI will support the coordination of this community and promote opportunities for training, documentation, and knowledge sharing across projects and cycles. Applications may be submitted by domestic and foreign nonprofit organizations including public and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local government, and eligible agencies of the federal government.

For-profit organizations are not eligible to receive funding but may be involved in projects as a collaborator. All grants will be awarded to institutions, not individuals. There may be more than one application submitted by each organization.

Each application should designate one Principal Investigator (PI) as the Coordinating Principal Investigator (Coordinating PI). The Coordinating PI will act as the administrative contact between CZI and all other PIs on the grant (Co-PIs). The Coordinating PI must submit the application on behalf of all PIs.

The Coordinating PI must be affiliated with the institution submitting the application, and grant funds will be awarded to that institution, which will take responsibility for distributing funds to any other institutions. Note that institutions outside the U.S. may not subcontract to U.S. institutions, so please be mindful when selecting the Coordinating PI/institution.

All key personnel must be named in the grant in the budget section along with their percent effort. This includes graduate students, postdocs, and staff scientists. Although recruiting new members to the lab is allowable, it is strongly encouraged that key personnel are in place at the outset of the grant to allow for consistent community building and project progression.

Each application must have a minimum of one PI (Coordinating PI), but may designate up to three total PIs (one Coordinating PI and up to two Co-PIs). Principal Investigators may serve as Coordinating Principal Investigator on multiple applications provided that the proposed scope of work for all applications is non-overlapping. PIs/Co-PIs on one application may be employed at the same or at different institutions.

PIs and Co-PIs must each be permitted to receive grant support by the organization they are applying with. This criteria may be defined differently in different types of organizations.

Examples of eligible positions are: Non-tenure track faculty or staff scientists who lead a lab or are engaged in academic activities and are permitted to apply for grants by their institution; Researchers with expertise in the relevant areas that are affiliated with or supported by an institution and permitted to apply for grants; and Postdoctoral fellows and graduate students who are permitted to apply for grants by their institution and apply through the institution at which they will conduct the research.

For graduate students or postdoctoral scholars who wish to participate in a grant but are not eligible to apply for grants through their institution, applications must be submitted through one of the eligible parties listed above. Co-PIs from companies are permitted as long as no funds are requested to support them or their work. Early-career investigators are strongly encouraged to apply as Coordinating PIs as well as Co-PIs.

We believe that the strongest teams incorporate a wide range of voices. Those underrepresented in science and technology are strongly encouraged to apply. Successful awardees from the first and second cycle are eligible to apply in this cycle, with a budget and scope of work that can be either similar or altered depending on project needs.

These applications will be evaluated alongside new applications. Unfunded applications from previous cycles can be submitted in this cycle after revision. Meta employees, including employees of any subsidiary Meta entities, as well as employees of Chan Zuckerberg Initiative, LLC, are not permitted to apply.

CZI reserves the sole right to decide if an applicant PI and applicant organization meet the eligibility requirements. CZI reserves the right to request budget changes prior to award. We welcome applications from any country, provided the proposed work is compliant with the United States Treasury Department’s Office of Foreign Asset Control (OFAC) sanctions program.

Prior to award, all grant applications will be reviewed for compliance with the United States Treasury Department’s Office of Foreign Asset Control (OFAC) sanctions program, the United States Department of Commerce’s export administration regulations, the Foreign Corrupt Practices Act (FCPA), any other applicable U.S. laws and regulations, and any corresponding laws and regulations in the country where the applicant is based.

All grant agreements will also require the grantee to comply with these laws and regulations. For additional information please refer to: the U.S. Treasury Department’s resources , the International Trade Administration’s website on US Export Controls , and the Department of Justice’s website on the FCPA .

While applicants from all countries are welcome to apply, because of required ongoing compliance with U.S. sanctions and export controls, an applicant’s funding eligibility may need to be reassessed if the applicable laws and regulations change at any time.

As a result, even if an applicant is eligible to receive funding at the time the application is reviewed, the applicant’s status may change later in the process or during the course of the grant term. CZI suggests that you consult your home institution to determine eligibility to apply for this grant and your institutional policy on indirect costs.

For questions about eligibility for this award or the application process, please contact us in advance of the proposal deadline at sciencegrants@chanzuckerberg. com . Deadline extensions will not be granted.

All applications must be completed and submitted through CZI’s online grants management portal at https://apply. chanzuckerberg. com .

It is recommended that applicants familiarize themselves with this portal well in advance of the application deadline. Detailed application instructions are available on the Chan Zuckerberg Initiative website , as well as in the grants management portal . We invite applications for consideration for funding during three distinct cycles Cycle 3 Application opening date Cycle 3 Applications due by 5 p.

m. Pacific Time Cycle 3 Earliest notification of decisions (subject to change) Cycle 3 Earliest start date (subject to change) Award period and start date: Proposed projects should be 18 months; expected start date for awards in Cycle 3 is August 1, 2024.

Grants will be awarded at two levels: Focused Projects: $200,000 USD total costs (inclusive of up to 15 percent indirect costs) for grants that primarily support the effort of one to two full-time employees (FTEs) working on a given project.

These efforts will benefit from additional collaborations in the network but will generally be directed towards an extension of existing tools for subsampling or querying cell atlases at scale, development of methods to help unlock mysteries of cells, or application and evaluation of novel techniques to open problems in single-cell biology; and Expanded Projects: $400,000 USD total costs (inclusive of up to 15 percent indirect costs) for networked grants that will require the participation of two to four FTEs.

These projects may require dedicated effort from multiple projects to undertake more extensive analysis that enables insight into a specific biological question, methods to connect data across scales, or improvement of existing tools that enable greater insight into health and disease through applications such as predicting cellular response to perturbations, modeling regulatory networks, and deciphering cell-cell interactions and spatial organization.

Funding is not intended to support experimental data generation; and Indirect costs cannot exceed 15 percent of direct costs for any grant proposal. Number of Principal Investigators: Each application must have one Coordinating Principal Investigator (PI), but may designate up to three total PIs (one Coordinating Principal Investigator and up to two Co-PIs).

Detailed Application Instructions The Chan Zuckerberg Initiative uses SurveyMonkey Apply (SMApply) as its grants management portal. All applications must be submitted through this portal (https://apply. chanzuckerberg.

com). SMApply is configured to work best using the Google Chrome browser. It is recommended that you familiarize yourself with this portal well in advance of any deadlines.

Deadline extensions will not be granted. Eligibility: Please refer to the RFA announcement . Grant period and start date: Awards will be 18 months in duration; expected start date for Cycle 3 is August 1, 2024.

Grant amount: $200,000 USD total costs (inclusive of up to 15 percent indirect costs) for Focused Projects or $400,000 USD total costs (inclusive of up to 15 percent indirect costs) for Expanded Projects . Indirect costs cannot exceed 15 percent of direct costs.

Number of Principal Investigators (PI and Co-PIs): Each application must have a minimum of one PI (Coordinating PI), but may designate up to three total PIs (one Coordinating PI and up to two Co-PIs). Principal Investigators may serve as Coordinating Principal Investigator on multiple applications provided that the proposed scope of work for all applications is non-overlapping.

Principal Investigators may serve as Co-PI on multiple applications provided that the proposed scope of work for all applications is non-overlapping. PIs/Co-PIs on one application may be employed at the same or different institutions. Institutional sign-off is required for submission.

The application consists of the following sections (called tasks in the grants portal): Coordinating PI Details, Organization Details for Coordinating PI, Equal Opportunity & Diversity, Project Details, Budget Description, Biosketches, Optional Attachments. Coordinating PI Details: Complete all fields in this task; all fields are required.

The information entered should be for the Coordinating Principal Investigator (Coordinating PI), who will be the person submitting the application on behalf of the team. The Coordinating PI will take responsibility for managing the group collaboration and be the administrative point of contact for CZI and any partners.

Note that institutions outside the U.S. may not subcontract to U.S. institutions, so please be mindful when selecting the Coordinating PI/institution. Information about the Co-Principal Investigator(s) on the proposal should be entered where requested in the Project Details part of the application.

Name and email (auto-filled): To edit your name or email, please do so in your account information by clicking your name in the upper right corner and clicking My Account in the dropdown menu. Career status: Select early-career (0 to 6 years), mid-career (6+ to 10 years), or neither.

Note: Early- or mid- career status is not required to be eligible for this RFA, although we encourage participation and leadership from early-career researchers.

Early-Career Definition: In the context of this RFA, an early-career investigator is someone who has been in an independent position for no more than six years at the time of application (i.e. started their first independent position between December 5, 2017 and December 5, 2023). Graduate students and postdocs who are eligible to apply should select this option.

Mid-Career Definition: In the context of this RFA, a mid-career investigator is someone who has been in an independent position for more than six to 10 years at the time of application (i.e. started their first independent position between December 5, 2013 and December 4, 2017). Short narrative biography of the Coordinating PI (maximum of 100 words). ORCID iD: Enter in format XXXX-XXXX-XXXX-XXXX.

ORCID iDs are unique, digital identifiers that distinguish individual scientists and unambiguously connect their contributions to science over time and across changes of name, location, and institutional affiliation. ORCID iDs will be used to streamline reporting in our applications and grant reports to reduce the burden on grantees. For more information and to register, please visit https://orcid.

org/register . (Please contact us at sciencegrants@chanzuckerberg. com if you wish to opt out).

Organization Details for Coordinating PI: Complete all fields in this task; all fields are required . The information entered should be for the organization of the Coordinating Principal Investigator (Coordinating PI), who will be the person submitting the application on behalf of the team.

The Coordinating PI must be affiliated with the organization listed, and grant funds will be awarded to this organization, which will take responsibility for distributing funds to the institutions of the other team members. Organization name/Street address/City/State/Country/Website. Type of Organization (Academic, Other Nonprofit, Government, Other).

Tax ID: Enter your organization’s Employer Identification Number (EIN), as assigned by the Internal Revenue Service in the 9-digit format (XX-XXXXXXX; 10 characters total). Foreign organizations or others who do not have an EIN should enter 44-4444444. Organizational/Administrative Contact: List the name and contact information for the administrative contact to discuss additional information needed, if selected for award.

First name, Last name, Title/Position, Email. Signing Official: List the name and contact information for the person authorized to sign on behalf of your organization. First name, Last name, Title/Position, Email.

First name, Last name, Title/Position, Email. Institutional Approval Form : Upload as a single PDF.

This form should be reviewed and signed by a person authorized to sign on behalf of your organization agreeing to the stated institutional and investigator requirements and commitments on data, resource sharing, and publication policies, as well as endorsing/verifying your application materials and confirming their ability to receive funding for the project.

In the event of an award, all funds will be awarded to the Coordinating PI institution as the prime institution, and the Coordinating PI institution will be responsible for ensuring compliance of all of the terms, including compliance of all partners/subcontract institutions. These policies are non-negotiable. This form should only be signed if the organization is able to comply with the terms as stated.

While CZI does not require sign-off by all of your partner institutions, please refer to what your institution requires. Note: digital signatures are permitted as long as the document is not encrypted or password-protected. Equal Opportunity & Diversity: CZI Science supports the science and technology that will make it possible to cure, prevent, or manage all diseases by the end of this century.

Everyone is affected by disease, yet different communities are affected by or experience disease in different ways. Moreover, due to systemic barriers, the scientific enterprise itself is not a place where all voices and talents thrive.

We believe the strongest scientific teams — encompassing ourselves, our grantees, and our partners — incorporate a wide range of backgrounds, lived experiences, and perspectives that guide them to the most important unsolved problems. To enable our work, we incorporate diverse perspectives into our strategy and processes, and we also seek to empower community partners to engage in science.

We request demographic information associated with applications submitted to CZI in response to our open calls. This information helps us learn from the RFA process, as well as improve our strategies to help ensure members of underrepresented or marginalized groups in science are aware of and able to apply to CZI opportunities.

Please note that answering the questions below is voluntary, and receiving funding is not contingent on providing this information. Demographic information provided may be used in our grant-making process but will not be used as the sole or determinative factor in our grant funding decisions. We may also publish aggregated data in various public forums, such as a website or blog.

All responses will be shared only with limited personnel and service providers, who will use that information only for the purposes described in this paragraph. If you have any additional questions about why we ask this, what we do with the data, or to share suggestions for improvement, please reach out to sciencegrants@chanzuckerberg. com .

The information below may be entered for the Coordinating PI, who will be submitting the application on behalf of the team. The categories listed below may not capture all possible identities; in the event that the categories do not accurately reflect your identities, please use the space provided to self-describe. What is your race/ethnicity?

(optional) What is the year of your last academic degree? (optional) What is your gender? (optional) Are you transgender?

(optional) Are you a member of the LGBTQIA+ community? (optional) Do you have one or more disabilities? Please specify (optional) The Coordinating PI may also provide aggregated information on the demographics of the Co-Prinicipal Investigators (Co-PIs) listed in the Project Details section of the application if those Co-PIs agree to share that information with CZI.

The categories listed below may not capture all possible identities; in the event that the categories do not accurately reflect their identities, please use the space provided to describe. How many of the Co-PIs self-identify as each of the following genders? Woman, Man, Non-binary/Third gender, Prefer not to say, Prefer to describe (optional) How many of the Co-PIs self-identify as each of the following races/ethnicities?

Two or More Races, Black and/or African American, Asian, White, Hispanic or Latinx, Middle Eastern or North African, Native Hawaiian or Other Pacific Islander, American Indian or Alaska Native, Prefer not to say, Prefer to describe (optional) Project Details: Complete all sections in this task. All sections are required. Project Title (auto-filled) : Project title is limited to 60 characters, including spaces.

If you need to edit your proposal title, navigate to your application summary page, click on the three dots to the right of the application title (next to the Preview link) and select Rename from the dropdown menu. Project Purpose : One sentence (maximum of 200 characters including spaces). Please use a third-person voice.

Example: To develop a series of workshops and tutorials to increase utilization of single-cell data in biomedical research. Award Type : Single selection: Focused ($200k limit) or Expanded ($400k limit) Amount Requested : Enter the total budget amount requested in U.S. dollars, including indirect costs; this number should match the total described in the Budget section. Enter whole numbers only (no dollar signs, commas, or cents).

This amount should be no more than $200,000 USD total costs (inclusive of up to 15 percent indirect costs) for Focused awards or $400,000 USD total costs (inclusive of up to 15 percent indirect costs) for Expanded awards. Did you previously apply for funding under the CZI Data Insights RFA? Yes/No. If yes, provide the application number: e.g., DI-0000005345.

Did you previously receive funding under the CZI Data Insights RFA? Co-Principal Investigators : Indicate the number of Co-Principal Investigators (maximum of two), not including the Coordinating PI. Complete the table with the following information for each Co-PI.

Do not include the Coordinating PI in this section . You may need to use the scroll bar at the bottom of the table to scroll right to view and complete all fields. Alternatively, you can tab to move through and complete the fields.

For each Co-PI, please provide: Co-PI name, Title/Position, Degrees, ORCID ID (format: XXXX-XXXX-XXXX-XXXX), Email, Career status In the context of this RFA, an early-career investigator is someone who has been in an independent faculty position (or equivalent) for no more than six years at the time of application, i.e. started their first independent position between August 25, 2016 and August 25, 2022, and mid-career as someone who has been in an independent faculty role (or equivalent) for more than six to 10 years at the time of application, i.e. started their first independent position between Augsut 25, 2012 and August 24, 2016.

Funded/Unfunded by this CZI grant to support the proposed work Organization Name, Country, Website Type of organization (drop down menu: Academic, Other Nonprofit, Government, Company/industry, Other). Tax ID: Enter your organization’s Employer Identification Number (EIN), as assigned by the Internal Revenue Service in the 9-digit format (XX-XXXXXXX; total of 10 characters).

Foreign organizations or others who do not have an EIN should enter 44-4444444. Abstract: Describe your project in brief (maximum of 250 words). Keywords: Add keywords that capture the essence of your proposal; e.g., data imputation, batch effects removal, cell cycle identification, cell type identification, trajectory inference, cell–cell interaction, regulatory network inference.

Project / Work Plan : Describe the proposed work, including an overview of the primary challenges that the project seeks to address, and existing work that serves as a foundation (maximum of 1,000 words). Utility: Summarize how the project supports scientific researchers to gain more insight from single-cell data. Clarify the anticipated impact and utility it will have for the community (maximum of 500 words).

Data : Projects must propose and rely on existing data that is openly and freely available at the time of application. List all datasets that will be utilized in the proposed work along with URLs and/or DOIs where they can be accessed (maximum of 25). If you would like to include more than 25, please include a table for the additional datasets in the Optional Attachments section.

Dataset or publication name DOI link or URL to specific dataset(s) Examples: https://cellxgene. cziscience. com/collections/0a839c4b-10d0-4d64-9272-684c49a2c8ba or https://doi.

org/10. 1016/j. cell.

2021. 01. 053 Short description (maximum of 50 words) Software (optional): List programming language(s), packages, and tools used, if applicable (maximum of 50 words).

Milestones and Deliverables : List expected milestones and deliverables, and their expected timeline. Be specific and include (where possible) any goals for metrics the project is expected to reach upon completion of the grant. Please use a third-person voice (maximum of 250 words).

Diversity, Equity, and Inclusion (DEI) Plan : Advancing diversity, equity, inclusion, and representation is a core value for CZI, and we are requesting information on your efforts that will clarify how your project and/or team will incorporate similar values into the proposed project.

Potential areas of focus may include efforts to incorporate reproducible notebooks, documentation that encourages reuse, trainings, work that addresses health disparities, or other efforts (maximum of 250 words). Community Statement: In addition to the technical achievements of this RFA, there is a goal of building a community of projects that will complement one another and provide collaborative opportunities among participants.

Please clarify what the proposed project aims to gain and contribute to the larger network (maximum 250 words). Budget (one page maximum per PI): Upload in PDF format; budgets can be uploaded in a combined single PDF or one PDF for each Co-PI; one page maximum per PI; font must be 11 point or larger and margins must be at least one-half inch (top, bottom, left, and right) for all pages (letter size required).

Provide a detailed description of the costs to be funded by this grant at a high level and in tabular form, outlining costs for personnel (including names, if known), supplies, equipment, travel, meetings/hackathons/sprints, subcontracts, other costs, and up to 15 percent indirect costs (excluding equipment and subcontracts).

If budgets are provided for multiple PIs, the Coordinating PI should also generate a summary of no more than one page showing the distribution of grant funds across the PIs. Indirect costs are limited to up to 15 percent of direct costs. Indirect costs may not be assessed on capital equipment or subcontracts, but subcontractors may include up to 15 percent indirect costs of their direct costs.

Budget should be requested in U.S. dollars. Note that institutions outside the U.S. may not subcontract to U.S. institutions, so please be mindful when selecting the Coordinating PI/institution. International grantees must use all grant funds exclusively for activities conducted outside the United States of America.

Travel expenses to the United States (including round-trip tickets) should not be covered from the requested grant funds. Any attendance at CZI meetings in the U.S. will be covered by CZI outside of requested grant funds. All key personnel must be named along with their percent effort.

This includes graduate students, postdocs, and staff scientists. Although recruiting new members to the lab is allowable, it is strongly encouraged that key personnel are in place at the outset of the grant to allow for coordinated community building and project progression. Application budgets must reflect the actual needs of the proposal.

The Chan Zuckerberg Initiative will work closely with successful applicants to arrive at a mutually acceptable budget after review. Biosketches for Coordinating PI and Co-PIs : Upload the biosketches in PDF format for the Coordinating PI and for each of the Co-PIs. Biosketches can be uploaded in a combined single PDF or one PDF for each Co-PI; maximum of five pages per biosketch; NIH format or similar.

Do not include any biosketches for any additional collaborators beyond the Coordinating PI and Co-PIs, as listed. Optional Attachments : Upload in PDF format; attachments should be uploaded in a combined single PDF. Include up to a maximum of three pages of additional information.

This section can include figures, charts and tables, references for the project, or any additional material in support of the project. Uploading any additional information is completely optional and not required. The formatting and component requirements, including word and page limits indicated above, will be enforced by the review team.

Any submitted materials that exceed the word and page limits or do not follow the requirements will not be considered during the application review process. For administrative and programmatic inquiries pertaining to this RFA, please contact sciencegrants@chanzuckerberg. com .

For technical assistance with SMApply, please contact support@smapply. io , or while logged into SMApply, click on the information “i” link in the upper right corner and submit a help request ticket. The Chan Zuckerberg Initiative’s core values center around people, technology, collaboration, and open science.

We adhere to those values in both proposal selection and evaluation of progress. CZI will evaluate all applications for scientific merit and will seek independent expert review. ​Final decisions will be made by CZI staff in consultation with our scientific advisors.

There is no expectation of any specific number of awards, as this will depend on team size and project budgets, and CZI reserves the sole right to not recommend the funding of any applications. CZI does not provide feedback on decisions for unfunded proposals. Application and funding in earlier rounds will not impact eligibility