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Small Business Innovation Research and Small Business Technology Transfer Programs is sponsored by National Institutes of Health (NIH). NIH's SBIR and STTR programs support research and development in small businesses, with a focus on biomedical/behavioral research areas, including health tech and AI. These programs aim to stimulate technological innovation and increase private sector commercialization of innovations.
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U.S. Department of Health and Human Services National Institutes of Health The SBIR and STTR programs were reauthorized on April 13, 2026. Currently, NIH has no active SBIR or STTR Notices of Funding Opportunity (NOFOs). Future NOFOs are forecasted at Grants.
gov prior to opening for applications. The next standard receipt date is September 5, 2026. Learn if your company is eligible for NIH SBIR or STTR funding, how to apply , and what to expect during each step of the application process.
Multiple registrations are required to prepare your application and apply for funding.
Small Business Program Basics Understanding SBIR and STTR Foreign Disclosure and Risk Management SBIR and STTR Grants (NOFO s ) SBIR Contract Solicitations Commercialization Readiness Pilot (CRP) Small Business Transition Grant for New Entrepreneurs Navigate NIH's Research Areas Applicant Assistance Programs --> Transition Award (Coming Soon) Our team can help you maximize the benefits from NIH programs and resources which help you bring your innovations to life.
NIH's Technical and Business Assistance (TABA) Concept to Clinic Commercializing Innovation (C3i) The NIH is actively turning discovery into health by helping small businesses develop innovative technologies that improve health and save lives. See how .
Small Business Portfolio Overview Active Small Business Awards Research Evaluation and Commercialization Hubs (REACH) Search Technologies from Academic Centers and Hubs Our team can help you maximize the benefits from NIH programs and resources which help you bring your innovations to life. We value biomedical innovation and strive to empower scientists and entrepreneurs to bring their discoveries to patients.
HHS Small Business Program Managers Non-dilutive funding for early-stage research and development. [ Parent Announcements ] [ Specific Opportunities ] More information on HHS SBIR contracts is available on the NIH SBIR contracts webpage . NIH has committed $20 million to support academic product development and innovation.
Learn more about the five new Research Evaluation and Commercialization Hubs (REACH) in the funding opportunity announcement (RFA-OD-23-005) Standard Application Due Dates are September 5, January 5, and April 5. Due dates that fall on weekends or Federal holidays are moved to the next business day. Some SBIR/STTR grant solicitations are focused on specific research areas.
Some specific NOFOs, identified as RFAs (Requests for Applications) or PASs (Program Announcements with Set-aside funds), have funding set-aside in the Institute/Center's budget for that targeted program. National Institutes of Health Product Development Support Looking for the NIH SBIR & STTR site? The new seed.
nih. gov has everything you’re looking for about the NIH small business research and development programs (SBIR & STTR) . In addition, you can learn about other types of product development and commercialization support for NIH award recipients .
Questions? Check out About the NIH SEED Office or email us at [email protected] .
According to the current listing, eligibility includes: U.S.-owned and operated small businesses with a focus on biomedical/behavioral research areas and strong potential for commercialization. Confirm the full requirements in the official notice before applying.
The current listing shows varies (Phase I generally up to $256,580; Phase II up to $1,710,531). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Small Business Innovation Research and Small Business Technology Transfer Programs are due September 5, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Small Business Innovation Research and Small Business Technology Transfer Programs is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward interdisciplinary projects that leverage AI, machine learning, and advanced data science to address pressing questions in biomedical and public health research. It seeks to advance fundamental scientific and engineering contributions across disciplines to solve key health problems.
NIH R25 Summer Research Education Experience Program is a grant from the National Institutes of Health (NIH) that funds universities and institutions of higher education to provide summer research experiences in environmental health sciences to high school students, college undergraduates, and science teachers. Administered through the National Institute of Environmental Health Sciences (NIEHS), the program aims to attract young people to scientific careers and help teachers communicate about the scientific process more effectively. Eligible applicants are U.S. institutions eligible for NIH grants. The application deadline was March 17, 2026.
NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32) is a grant from the National Cancer Institute (NCI) that funds early postdoctoral fellows from diverse backgrounds, including underrepresented groups, to pursue research training in cancer-related fields. The K32 award supports fellows within 12 months prior to transitioning into, or within the first two years of, a postdoctoral position. The program, operated through NCI's Center to Reduce Cancer Health Disparities (CRCHD), aims to enhance the pool of qualified diverse cancer researchers. Beginning with the June 12, 2025 due date, the CURE ACE Award is available in both Independent Clinical Trial Required and Independent Clinical Trial Not Allowed versions. Eligible applicants must be U.S. citizens or permanent residents at time of award.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward interdisciplinary projects that leverage AI, machine learning, and advanced data science to address pressing questions in biomedical and public health research. It seeks to advance fundamental scientific and engineering contributions across disciplines to solve key health problems.
As of October 1, 2025, NIH no longer posts Notices of Funding Opportunity in the NIH Guide — Grants.gov is now the single official source (NOT-OD-25-143). The weekly Guide table-of-contents email that thousands of investigators relied on to discover funding no longer lists opportunities. Combined with the January 25, 2026 SciENcv certified-PDF requirement, the mechanics of finding and applying for NIH money have changed underneath everyone. Here is how to rebuild your discovery workflow so nothing slips through.
Read articleThe HEAL Initiative's Studies to Enable Analgesic Discovery award (RFA-NS-25-023) puts federal money exactly where private capital won't go — the assay-building, screening, and hit-characterization stage of non-opioid pain therapeutics. It's a phased R61/R33, up to $350,000 in direct costs per year, with the next application deadline September 17, 2026. Here is how the two-phase structure works, who's eligible, and how to build a proposal that survives the R61-to-R33 milestone gate.
Read articleThe NIH Director's New Innovator Award (DP2, RFA-RM-27-002) closes August 17, 2026, offering roughly 30 Early Stage Investigators up to $475,000 in direct costs a year for five years — $2.375 million total — to pursue bold ideas without the preliminary data a standard R01 demands. Here is how the High-Risk, High-Reward program actually evaluates applications, who qualifies, and why the usual R01 instincts will sink you.
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