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Find similar grantsThis SBIR/STTR award opportunity is focused on technologies that support DOE's Genesis Mission, which aims to advance American leadership in artificial intelligence (AI), quantum information science, biotechnology, and advanced materials.
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Or search similar grants →According to the current listing, eligibility includes: For-profit U. S. small businesses that meet Small Business Administration eligibility requirements. Participation is limited to U. S. small businesses. Confirm the full requirements in the official notice before applying.
The current listing shows up to $10,000,000 across multiple awards (Phase I projects). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (aligned with Genesis Mission for AI) is funded by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). Verify program details on the funder's official page before applying.
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Small Business Innovation Research (SBIR) Program Phase I (DOE Genesis Mission) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This DOE SBIR Phase I opportunity focuses on the Genesis Mission, supporting breakthrough technologies in areas including "Scaling the Biotechnology Revolution." Projects related to Pichia pastoris, particularly in areas of biotechnology for energy production, biomaterials, or sustainable processes, would be relevant. This is a pitch-first application process.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (Genesis Mission Phase I) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I opportunity, focused on DOE's Genesis Mission, supports technologies in four areas including "Scaling the Biotechnology Revolution." Pichia pastoris is a significant host for biotechnology, particularly in the production of enzymes, biopharmaceuticals, and other biomolecules. Proposals advancing biotechnology, especially those with strong commercial potential and alignment with DOE mission areas, would be relevant.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn August 24, 2026, DOE and SBA signed a memorandum of agreement creating the Small Business Investment Company-Energy Initiative, pointing a $58 billion SBA-leveraged investment program at DOE's technology priorities. No application, no NOFO, no deadline. Here is how SBIC capital actually works, why a January 2026 rule change made this possible, and what a company sitting on a DOE Phase II award should do about it.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
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