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Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). This program provides additional funding for small businesses that have successfully completed Phase II SBIR projects and require extraordinary time and effort in the R&D phase to reach the marketplace. It focuses on biomedical technologies with public health impact.
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Opportunity Listing - NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 837 -- Cardiovascular Diseases Research 93. 395 -- Cancer Treatment Research 93.
307 -- Minority Health and Health Disparities Research 93. 273 -- Alcohol Research Programs 93. 865 -- Child Health and Human Development Extramural Research 93.
840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93. 394 -- Cancer Detection and Diagnosis Research 93. 839 -- Blood Diseases and Resources Research 93.
233 -- National Center on Sleep Disorders Research 93. 393 -- Cancer Cause and Prevention Research 93. 351 -- Research Infrastructure Programs 93.
350 -- National Center for Advancing Translational Sciences 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93. 242 -- Mental Health Research Grants 93.
867 -- Vision Research 93. 838 -- Lung Diseases Research 93. 313 -- NIH Office of Research on Women's Health 93.
855 -- Allergy and Infectious Diseases Research 93. 853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders 93. 859 -- Biomedical Research and Research Training Last Updated: June 1, 2026 View version history on Grants.
gov The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).
Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project.
This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.
Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Grantor contact information NIH SEED (Small business Education and Entrepreneurial Development) NIH SEED (Small business Education and Entrepreneurial Development) File name Description Last updated PA-27-101-Revised-Full-Announcement. html PA-27-101-Revised-Full-Announcement.
html Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Small businesses that have completed a Phase II SBIR project and require additional funding for R&D. Applicants should connect with NIH Institute and Center scientific program officers early. Confirm the full requirements in the official notice before applying.
The current listing shows up to $2,153,927 (Phase II, with waiver topics reaching $3 million). Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was September 5, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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