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Small Business Innovation Research (SBIR) Program is sponsored by National Institute of Neurological Disorders and Stroke (NINDS) of the NIH. The NINDS Small Business Innovation Research (SBIR) Program supports small businesses in conducting innovative neuroscience research and development with the potential for commercialization and public benefit, including projects related to traumatic brain injury.
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Opportunity Listing - NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional) NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93.
853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders Last Updated: May 13, 2026 View version history on Grants.
gov (Reissue of PAR-18-665) This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) applications from small business concerns (SBCs) that seek additional funding to support clinical trials for projects that were previously funded by NIH SBIR and STTR Phase II awards.
The projects must focus on products related to the mission and goals of the National Institute of Neurological Disorders and Stroke (NINDS) and may evaluate drugs, biologics, devices, or diagnostics, as well as surgical, behavioral or rehabilitation therapies.
Since conducting the clinical trials needed for commercialization may be capital-intensive, the FOA aims to facilitate the transition of SBIR Phase II projects to the commercialization stage by promoting partnerships between NIH's SBIR/STTR awardees and third-party investors and/or strategic partners.
Consistent with the goals of this funding initiative and as required by the SF424 instructions for all SBIR Phase II applications, applicants must submit a Commercialization Plan, which should include details on any independent third-party investor funding that has already been secured or is anticipated during the project period.
It is expected that the level of this independent third-party funding will equal or exceed the NINDS funds being requested throughout the SBIR Phase IIB project period. Other Eligible Applicants include the following:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. Grantor contact information See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
File name Description Last updated PAR-24-221-Full-Announcement. html PAR-24-221 Full Announcement Text Jun 20, 2024 03:11 PM UTC Link to additional information https://grants. nih.
gov/grants/guide/pa-files/PAR-24-221. html Archived: November 18, 2025 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: American-owned and independently operated, for-profit small businesses with no more than 500 employees. The principal researcher must be employed by the business. Confirm the full requirements in the official notice before applying.
The current listing shows phase I: up to $256,131; Phase II: up to $1,680,879 (hard caps, but can be exceeded with specific NOFOs). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Small Business Innovation Research (SBIR) Program is funded by National Institute of Neurological Disorders and Stroke (NINDS) of the NIH. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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