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Small Business Innovation Research (SBIR) Program (Parent SBIR [R43/R44]) is sponsored by National Institutes of Health (NIH), Department of Health and Human Services (HHS), Centers for Disease Control (CDC), Food and Drug Administration (FDA). This omnibus solicitation encourages small businesses to submit investigator-initiated SBIR grant applications for research and development across a broad spectrum of health-related topics with commercialization potential.
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Or search similar grants →Extracted from the official opportunity page/RFP to help you evaluate fit faster.
Opportunity Listing - NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 068 -- Chronic Diseases: Research, Control, and Prevention 93. 351 -- Research Infrastructure Programs 93.
083 -- Prevention of Disease, Disability, and Death through Immunization and Control of Respiratory and Related Diseases 93. 350 -- National Center for Advancing Translational Sciences 93. 273 -- Alcohol Research Programs 93.
867 -- Vision Research 93. 859 -- Biomedical Research and Research Training 93. 326 -- Strengthening Public Health through Surveillance, Epidemiologic Research, Disease Detection and Prevention 93.
847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93. 395 -- Cancer Treatment Research 93. 879 -- Medical Library Assistance 93.
073 -- Birth Defects and Developmental Disabilities - Prevention and Surveillance 93. 393 -- Cancer Cause and Prevention Research 93. 084 -- Prevention of Disease, Disability, and Death by Infectious Diseases 93.
233 -- National Center on Sleep Disorders Research 93. 394 -- Cancer Detection and Diagnosis Research 93. 173 -- Research Related to Deafness and Communication Disorders 93.
070 -- Environmental Public Health and Emergency Response 93. 121 -- Oral Diseases and Disorders Research 93. 136 -- Injury Prevention and Control Research and State and Community Based Programs 93.
840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93. 865 -- Child Health and Human Development Extramural Research 93. 846 -- Arthritis, Musculoskeletal and Skin Diseases Research 93.
837 -- Cardiovascular Diseases Research 93. 172 -- Human Genome Research 93. 279 -- Drug Use and Addiction Research Programs 93.
855 -- Allergy and Infectious Diseases Research 93. 286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health 93. 113 -- Environmental Health 93.
839 -- Blood Diseases and Resources Research 93. 213 -- Research and Training in Complementary and Integrative Health 93. 103 -- Food and Drug Administration Research 93.
143 -- NIEHS Superfund Hazardous Substances_Basic Research and Education 93. 361 -- Nursing Research 93. 307 -- Minority Health and Health Disparities Research 93.
242 -- Mental Health Research Grants 93. 313 -- NIH Office of Research on Women's Health 93. 142 -- NIEHS Hazardous Waste Worker Health and Safety Training 93.
853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders 93. 838 -- Lung Diseases Research Last Updated: June 1, 2026 View version history on Grants. gov The Small Business Innovation Research (SBIR) program helps United States small business concerns (SBCs) bring scientific innovations to the marketplace.
The SBIR program supports feasibility studies to later research and development (R&D) needed to develop a commercial product. Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir. gov/apply) are eligible to submit applications for this opportunity.
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Grantor contact information NIH SEED (Small business Education and Entrepreneurial Development) NIH SEED (Small business Education and Entrepreneurial Development) File name Description Last updated PA-27-100-Revised-Full-Announcement. html PA-27-100-Revised-Full-Announcement.
html Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Small business concerns (SBCs) that meet SBIR eligibility requirements. Confirm the full requirements in the official notice before applying.
The current listing shows up to $275,766 for Phase I; Up to $1,838,436 for Phase II (statutory limits, waivers may apply for higher amounts). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Small Business Innovation Research (SBIR) Program (Parent SBIR [R43/R44]) are due September 5, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Small Business Innovation Research (SBIR) Program (Parent SBIR [R43/R44]) is funded by National Institutes of Health (NIH), Department of Health and Human Services (HHS), Centers for Disease Control (CDC), Food and Drug Administration (FDA). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32) is a grant from the National Cancer Institute (NCI) that funds early postdoctoral fellows from diverse backgrounds, including underrepresented groups, to pursue research training in cancer-related fields. The K32 award supports fellows within 12 months prior to transitioning into, or within the first two years of, a postdoctoral position. The program, operated through NCI's Center to Reduce Cancer Health Disparities (CRCHD), aims to enhance the pool of qualified diverse cancer researchers. Beginning with the June 12, 2025 due date, the CURE ACE Award is available in both Independent Clinical Trial Required and Independent Clinical Trial Not Allowed versions. Eligible applicants must be U.S. citizens or permanent residents at time of award.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward interdisciplinary projects that leverage AI, machine learning, and advanced data science to address pressing questions in biomedical and public health research. It seeks to advance fundamental scientific and engineering contributions across disciplines to solve key health problems.
The HEAL Initiative's Studies to Enable Analgesic Discovery award (RFA-NS-25-023) puts federal money exactly where private capital won't go — the assay-building, screening, and hit-characterization stage of non-opioid pain therapeutics. It's a phased R61/R33, up to $350,000 in direct costs per year, with the next application deadline September 17, 2026. Here is how the two-phase structure works, who's eligible, and how to build a proposal that survives the R61-to-R33 milestone gate.
Read articleThe CDC's Notice of Funding Opportunity CDC-RFA-JG-26-0056, Continuing to Enhance Global Health Security, closes for applications on June 25, 2026, with $75 million on the table and eight cooperative agreements anticipated. The NOFO sits inside an unusually compressed window for global health implementing partners — after the USAID dismantling and the 2025 CDC reorganization, this is one of the largest remaining flexible federal vehicles for outbreak-prevention work executed through bilateral partnerships with foreign health ministries. Here is what the solicitation requires, why the eligibility design favors specific applicant types, and what to do if you are still considering whether to apply.
Read articleNIH posted PAR-27-032 — Maximizing Investigators' Research Award for Early Stage Investigators — on May 12 as the first NOFO under the HHS SimplerNOFO initiative. Plain language, checklists, restructured sections, and explicit guidance replace the dense traditional NIH announcement. What the redesign means for grant writing strategy across HHS and which NOFOs are next in line.
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