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Small Business Innovation Research (SBIR) Program Phase I (DOE Genesis Mission) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This DOE SBIR Phase I opportunity focuses on the Genesis Mission, supporting breakthrough technologies in areas including "Scaling the Biotechnology Revolution."
Projects related to Pichia pastoris, particularly in areas of biotechnology for energy production, biomaterials, or sustainable processes, would be relevant. This is a pitch-first application process.
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Or search similar grants →According to the current listing, eligibility includes: For-profit U.S. small businesses that meet Small Business Administration eligibility requirements. Applicants must first submit a short pitch application. Confirm the full requirements in the official notice before applying.
The current listing shows approximately 40 awards from a combined $10,000,000 Phase I budget, with up to $44,000,000 in potential cumulative funding across all phases. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was September 10, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Small Business Innovation Research (SBIR) Program Phase I (DOE Genesis Mission) is funded by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (Genesis Mission Phase I) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I opportunity, focused on DOE's Genesis Mission, supports technologies in four areas including "Scaling the Biotechnology Revolution." Pichia pastoris is a significant host for biotechnology, particularly in the production of enzymes, biopharmaceuticals, and other biomolecules. Proposals advancing biotechnology, especially those with strong commercial potential and alignment with DOE mission areas, would be relevant.
DOE Genesis Mission SBIR/STTR Phase I Funding Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This funding opportunity supports small businesses in developing breakthrough technologies that advance DOE's Genesis Mission. The opportunity targets four AI-driven topic areas: biotechnology, quantum computing, materials design, and autonomous laboratories.
The Small Business Innovation Research (SBIR) Program for CHIPS for America – CHIPS Metrology seeks applications from eligible applicants to explore the technical merit or feasibility of an innovative idea or technology with the aim of developing a viable product or service that will be introduced to the commercial microelectronics marketplace. This NOFO contains multiple topics on research projects for critically needed measurement services, tools, and instrumentation; innovative manufacturing metrologies; novel assurance and provenance technologies and advanced metrology research and development (R&D) testbeds to help secure U.S. leadership in the global semiconductor industry. Funding Opportunity Number: 2024-SBIR-CHIPS-01. Assistance Listing: 11.042,11.620. Funding Instrument: CA. Category: ST.
JobsOhio Small Business Grant is sponsored by JobsOhio. This grant offers financial support for real estate investments, equipment, and more for eligible projects and businesses. While broad in scope, if the autonomous scientific instrumentation or miniaturized microscope sensor payload directly leads to job creation or significant fixed-asset investment in Ohio, it could be relevant.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn August 24, 2026, DOE and SBA signed a memorandum of agreement creating the Small Business Investment Company-Energy Initiative, pointing a $58 billion SBA-leveraged investment program at DOE's technology priorities. No application, no NOFO, no deadline. Here is how SBIC capital actually works, why a January 2026 rule change made this possible, and what a company sitting on a DOE Phase II award should do about it.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
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