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Small Business Technology Transfer Grant Parent STTR [R41/R42] Clinical Trial Optional is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA). Similar to SBIR, the STTR program focuses on funding research and development.
The core difference is the requirement for a formal collaboration between the small business and an eligible non-profit research institution.
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Or search similar grants →Extracted from the official opportunity page/RFP to help you evaluate fit faster.
Opportunity Listing - NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders 93. 859 -- Biomedical Research and Research Training 93.
361 -- Nursing Research 93. 213 -- Research and Training in Complementary and Integrative Health 93. 273 -- Alcohol Research Programs 93.
286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health 93. 879 -- Medical Library Assistance 93. 393 -- Cancer Cause and Prevention Research 93.
172 -- Human Genome Research 93. 394 -- Cancer Detection and Diagnosis Research 93. 838 -- Lung Diseases Research 93.
395 -- Cancer Treatment Research 93. 855 -- Allergy and Infectious Diseases Research 93. 840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93.
313 -- NIH Office of Research on Women's Health 93. 865 -- Child Health and Human Development Extramural Research 93. 351 -- Research Infrastructure Programs 93.
242 -- Mental Health Research Grants 93. 846 -- Arthritis, Musculoskeletal and Skin Diseases Research 93. 350 -- National Center for Advancing Translational Sciences 93.
233 -- National Center on Sleep Disorders Research 93. 867 -- Vision Research 93. 173 -- Research Related to Deafness and Communication Disorders 93.
839 -- Blood Diseases and Resources Research 93. 837 -- Cardiovascular Diseases Research 93. 121 -- Oral Diseases and Disorders Research 93.
307 -- Minority Health and Health Disparities Research 93. 279 -- Drug Use and Addiction Research Programs 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93.
113 -- Environmental Health Last Updated: June 1, 2026 View version history on Grants. gov The Small Business Technology Transfer (STTR) grant program helps United States small business concerns (SBCs) that partner with a nonprofit research institution bring scientific innovations to the marketplace. The STTR program supports feasibility studies to later stage research and development (R&D) needed to develop a commercial product.
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir. gov/apply) are eligible to submit applications for this opportunity. Refer to Section III.
Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed. Grantor contact information NIH SEED (Small business Education and Entrepreneurial Development) NIH SEED (Small business Education and Entrepreneurial Development) File name Description Last updated PA-27-102-Revised-Full-Announcement. html PA-27-102-Revised-Full-Announcement.
html Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: For-profit small businesses (less than 500 employees), majority-owned and controlled by U. S. citizens or permanent residents, with a Unique Entity ID and registered with SAM. Confirm the full requirements in the official notice before applying.
The current listing shows up to $275,000 for Phase I; $750,000 - $1.8 million for Phase II. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Small Business Technology Transfer Grant Parent STTR [R41/R42] Clinical Trial Optional are due September 5, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Small Business Technology Transfer Grant Parent STTR [R41/R42] Clinical Trial Optional is funded by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Small Business Innovation Research Grant Parent SBIR [R43/R44] Clinical Trial Optional is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA). This program provides non-dilutive funding for early-stage research and development (R&D) in biomedical technology with strong commercialization potential. It supports investigator-initiated ideas through parent grant announcements.
NIH Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA). This program supports small businesses conducting research and development (R&D) to develop commercial products that enhance health and well-being. It is a major source of early-stage funding for U.S. technology development and commercialization in biomedical and behavioral research, including medical devices, health IT, and digital health. Phase I focuses on establishing technical merit and feasibility. The program is offered by NIH, CDC, and FDA.
NIH Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) (Clinical Trial Optional) is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA). This omnibus solicitation supports small business innovation research across a broad spectrum of topic areas, including those relevant to brain-computer interfaces. It is a parent announcement for SBIR grants where a clinical trial may be optional.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
Innovation Grant is a grant from the Delta Dental of Arizona Foundation that funds nonprofit organizations pursuing unique, high-impact projects that improve health and wellness in Arizona communities. This two-year award supports original initiatives with measurable real-world impact, including programs serving underserved and uninsured populations through oral health education, disease prevention, and nutritional access. Projects must demonstrate the potential to make a meaningful difference in the community and stand apart from conventional approaches. Eligible applicants are Arizona-based nonprofit organizations. Awards total $100,000 per recipient over two years. The 2026 application cycle closed October 16, 2025, with recipients notified in late 2025 and funding made available shortly after.
The HEAL Initiative's Studies to Enable Analgesic Discovery award (RFA-NS-25-023) puts federal money exactly where private capital won't go — the assay-building, screening, and hit-characterization stage of non-opioid pain therapeutics. It's a phased R61/R33, up to $350,000 in direct costs per year, with the next application deadline September 17, 2026. Here is how the two-phase structure works, who's eligible, and how to build a proposal that survives the R61-to-R33 milestone gate.
Read articleThe NIH Extramural Loan Repayment Program pays up to $50,000 a year against educational debt at roughly a 50% success rate — better odds than almost any NIH research grant. For FY2027 the six extramural subcategories collapse into three: L30, L40, and L70. Applicants who would have used L32, L50, or L60 must now pick a new lane. Here is the crosswalk, the 20% debt-to-salary rule, and why the consolidation changes how you frame the research.
Read articleNOT-OD-26-098 bars K award funds from supporting clinical trials, feasibility studies, and ancillary studies for due dates on or after October 12, 2027, and retires the Independent Clinical Trial Required K NOFOs. NIH has no replacement mechanism yet — only an RFI closing September 30, 2026. Here is what the policy actually says, who it hits, and how to sequence around it.
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