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Small Business Transition Grant for New Entrepreneurs (SBIR) — R43 Phase I is a grant from the National Institutes of Health (NIH) that funds early-stage scientific innovation by small businesses aiming to bring biomedical breakthroughs to the commercial marketplace. The Phase I award supports feasibility research, evaluating technical merit and commercial potential of proposed innovations.
Eligible applicants are U.S. small business concerns, particularly new entrepreneurs, applying under PAR-24-131. Awards cover up to approximately $306,872 in total costs for Phase I. The most recent deadline is September 5, 2026.
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Small Business Innovation Research Grants (SBIR) - Phase I (R43) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health Small Business Innovation Research Grants (SBIR) - Phase I (R43) To help small businesses bring scientific innovations to the marketplace. The SBIR supports research and development (R&D) awards to eligible United States small business concerns only.
The focus of a Phase 1 award is on the feasibility, technical merit, and commercial potential of the research project. Carefully read the Eligibility section of the funding opportunity for opportunity-specific organization eligibility requirements. Project Director/ Principal Investigator (PD/PI) Eligibility PD/PI primary employment (> 50%) should be with the small business.
Carefully read the Eligibility section of the funding opportunity for opportunity-specific PD/PI eligibility requirements. Small Business Innovation Research Grants (SBIR) - Phase I Use the Explore NIH Grant Opportunities tool to search Grants. gov. Ready to develop your application?
Learn from a step-by-step guide. Standard Due Dates apply. AIDS and AIDS-Related Applications Beginning with applications for Advisory Council Review in January 2027 (i.e., application due dates on or after May 25, 2026), NIH will no longer accept applications submitted on dedicated AIDS application due dates.
( NOT-OD-26-029 ) Standard Application Due Dates (when applicable) NIH SEED: Understanding SBIR and STTR website NIH Grants Policy Statement Section 18. 5 Small Business Innovation Research and Small Business Technology Transfer Programs For technical issues E-mail OER Webmaster
According to the current listing, eligibility includes: United States small businesses (new entrepreneurs), Phase I SBIR (PAR‑24‑131). Confirm the full requirements in the official notice before applying.
The current listing shows up to approximately $306,872 total costs for Phase I. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The most recent published deadline was September 5, 2026, which has passed. This is an annual program, so a new cycle should follow. Check the funder's website for the next application window.
Small Business Transition Grant for New Entrepreneurs (SBIR) — R43 Phase I is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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