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"Targeted Genome Editor Delivery (TARGETED) Challenge" is currently closed and not accepting applications.
Targeted Genome Editor Delivery (TARGETED) Challenge is sponsored by Department of Health and Human Services - National Institutes of Health. Subject of the Challenge: Recent advancements in the genome editing technology field have enabled scientists to manipulate genomic sequences rapidly and efficiently. Despite revolutionary progress in this area, several challenges remain.
Existing gene editing technologies like CRISPR-cas9, base editors and prime editors have great potential, but existing delivery technologies are not able to deliver gene editing technologies to many target tissues and cell types in sufficient quantities, which hinders clinical applications.
While some cell types, like hepatocytes in the liver, have many delivery technologies capable of delivering genome editors, there are many other organs and cell types that are harder to reach. The Targeted Genome Editor Delivery (TARGETED) Challenge is a $6,000,000 challenge to improve the current state of in vivo delivery technologies for genome editors in two Target Areas: 1. Programmable Delivery System for Gene Editing, and 2.
Crossing the Blood-Brain Barrier.
The National Institutes of Health (NIH), through the Common Fund’s Somatic Cell Genome Editing (SCGE) program, is seeking Participants with ideas or early-stage solutions to join the Challenge with the chance to win up to $1,000,000 and have their solution independently tested and validated in large animal models through NIH-supported independent evaluation relevant to preclinical assessments of investigational products.
The Challenge is a three-phase competition. In Phase 1, Participants will be asked to submit a proposal describing their proposed solution and how it will address the requirements for one of the Target Areas. Participants may submit proposed solutions to both Target Areas but must do so with separate proposals that independently address each Target Area’s requirements.
Up to ten proposals that are judged to best meet the requirements will each be awarded up to $75,000. Additional prizes of $50,000 may be awarded to additional meritorious solutions on the basis of the Ju
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Or search similar grants →According to the current listing, eligibility includes: The following Eligibility and Participation Rules will apply to this Challenge. NIH reserves the right to modify or amend these Rules for any subsequent Phase in order to best achieve the goals of the Challenge and advance the mission of the NIH. NIH may consider amending the Participation Rule regarding intellectual property and licensing of technologies in order to more effectively promote the development of therapeutics for a large number of diseases, including diseases that rarely attract private sector interest. Participants will be notified of any such changes prior to the launch of each Phase. Only Phase 2 winners are eligible to participate in Phase 3. Eligibility Rules: Participants may register for and compete in this Challenge in one of two ways: either as a Team ( i.e., registering as a group of individuals competing together but not on behalf of an established organization, institution, or corporation), or as an Entity ( i.e., registering as a group of individuals competing together on behalf of a legally established organization, institution, or corporation). To be eligible to win a prize under this Challenge, a Participant (whether a Team or an Entity) — a. Shall have registered to participate in the Challenge under the rules promulgated by the National Institutes of Health (NIH) as published in this announcement; b. Shall have complied with all the requirements set forth in this announcement; c. In the case of an Entity, shall be incorporated in and maintain a primary place of business in the United States. In the case of a Team, the Team Leader shall be a citizen or permanent resident of the United States. However, non-U.S. citizens and non-permanent residents can participate as a member of a Team or Entity that otherwise satisfies the eligibility criteria. Non-U.S. citizens and non-permanent residents are not eligible to win a monetary prize (in whole or in part). Their participation as part of a winning Team or Entity, if applicable, may be recogn. Confirm the full requirements in the official notice before applying.
The current listing shows $6,000,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was May 4, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Yes — Targeted Genome Editor Delivery (TARGETED) Challenge is offered by Department of Health and Human Services - National Institutes of Health and this listing comes from Challenge.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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