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The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is sponsored by U.S. Department of Energy (DOE) - Office of Science, Basic Energy Sciences (BES). This funding opportunity supports research at the intersection of artificial intelligence and basic energy sciences. It seeks to transform science and energy through the application of AI.
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GRANTS The Genesis Mission: Tra...
| U.S. DOE Office of Science(SC) The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026).
Genesis Mission: Informational Webinars The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026). Genesis Mission: Informational Webinars U.S. Department of Energy SC-43/Germantown Building 1000 Independence Ave. , SW sc.
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According to the current listing, eligibility includes: DOE National Laboratories and other Federal Agencies should carefully read the Funding Opportunity Announcement for eligibility. Confirm the full requirements in the official notice before applying.
Applications for The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) are due December 17, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is funded by U.S. Department of Energy (DOE) - Office of Science, Basic Energy Sciences (BES). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
DOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
Read articleThe DOE Genesis Mission RFA closed its Phase II window on May 19. With $293.76M, 21 topics, and 99 focus areas, it is the largest single federal AI-for-science procurement in 2026. Here is what survived the cut and what comes next.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
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