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The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks.
By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia.
The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Funding Opportunity Number: DE-FOA-0003612. Assistance Listing: 81.
049. Funding Instrument: O. Category: ST.
Award Amount: $500K – $16M per award.
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Or search similar grants →According to the current listing, eligibility includes: Eligible applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility. Cost sharing or matching funds are required. Confirm the full requirements in the official notice before applying.
The current listing shows $500K – $16M per award. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for The Genesis Mission: Transforming Science and Energy with AI are due December 17, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Yes — The Genesis Mission: Transforming Science and Energy with AI is offered by Office of Science and this listing comes from Grants.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
The U.S. Department of Energy issued 17,235 awards totaling roughly $60.7 billion to 3,453 recipients in FY2021-2025, with a median award of $540,000. The California Energy Commission ($1.43 billion) and X Energy, LLC ($931.3 million) were among the top recipients, and 41 percent of recipients won more than one separate award.
| Organization | Total awarded |
|---|---|
| State of California Energy Commission(CA) | $1.4B |
| US Sfr Owner LLC(WA) | $983.0M |
| X Energy, LLC(MD) | $931.3M |
| Department of Commerce Minnesota(MN) | $801.5M |
| Comptroller of Public Accounts(TX) | $782.3M |
| Department of Commerce Montana(MT) | $747.5M |
| Massachusetts Department of Energy Resources(MA) | $634.8M |
| Georgia Environmental Finance Authority(GA) | $630.1M |
Top recipients of U.S. Department of Energy assistance awards, FY2021–FY2025, ranked by total obligations (CFDA 81.x). Source: USAspending. Last verified July 2026.
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