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The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science, Basic Energy Sciences (BES). This funding opportunity focuses on transforming science and energy using Artificial Intelligence (AI). It supports research relevant to the mission of the DOE Office of Science, which includes Basic Energy Sciences.
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The Genesis Mission | Department of Energy A national initiative to build the world’s most powerful scientific platform. The Genesis Mission unites DOE National Labs, industry, academia, and more to harness AI for breakthroughs in energy dominance, discovery science, and national security. Inside the Genesis Mission The Genesis Mission is turning vision into action.
Building a national AI-for-science ecosystem. Advancing new partnerships. Developing cutting-edge capabilities.
All to accelerate scientific discovery. Addressing National Science and Technology Challenges in Key Areas DOE has identified national science and technology challenges to accelerate U.S. innovation and leadership. These challenges will deliver tangible benefits for the American people through the Genesis Mission’s AI platforms and partnerships.
American Science and Security Platform The American Science and Security Platform The Genesis Mission will build a complex integrated platform, connecting the world’s best supercomputers, experimental facilities, AI systems, and unique datasets.
Collaboration and Consortium Bringing Together World-Class Innovators The Genesis Mission brings together cross-sector and cross-functional leading experts to solve critical challenges at unprecedented speed. Learn More about Genesis Collaboration and Consortium In March 2026, DOE announced funding to advance the Genesis Mission’s efforts to tackle the nation’s most complex science and technology challenges.
Get details on the Request for Applications here: The Genesis Mission: Transforming Science and Energy with AI .
U.S. Department of Energy Announces More Than $800 Million in Partner Commitments to the Genesis Mission Secretary of Energy Chris Wright Announces First Genesis Mission Projects Selected to Accelerate AI-Driven Scientific Discovery United States and Japan Announce Historic $1 Billion Partnership Under President Trump’s Genesis Mission From CSIS: Betting on America | Can AI Accelerate Scientific Discovery?
Featuring Under Secretary Darío Gil From PowerMag: The Genesis Mission: How AI Supercomputing Is About to Reshape American Science and Energy Energy Department Announces $293 Million in Funding to Support Genesis Mission National Science and Technology Challenges Energy Department Launches ‘Genesis Mission’ to Transform American Science and Innovation Through the AI Computing Revolution Get Genesis Mission updates from the Under Secretary for Science.
Explore the Genesis Mission Genesis Mission National Science and Technology Challenges The American Science and Security Platform Genesis Mission Collaboration Office of the Under Secretary for Science Genesis Mission University Summit Report Genesis Mission Workforce Development RFI Summary Genesis Mission RFA Awards List Get Genesis Mission Updates Follow Under Secretary Gil on LinkedIn Follow Under Secretary Gil on X
According to the current listing, eligibility includes: May be open to one or more institution types; DOE National Laboratories and other Federal Agencies should review the announcement carefully for eligibility. Confirm the full requirements in the official notice before applying.
Applications for The Genesis Mission: Transforming Science and Energy with AI are due December 17, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
The Genesis Mission: Transforming Science and Energy with AI is funded by U.S. Department of Energy (DOE) Office of Science, Basic Energy Sciences (BES). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
FY26 Phase I Genesis Mission Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). The DOE SBIR/STTR Phase I Genesis Mission opportunity invites American small businesses to develop breakthrough technologies that advance the Genesis Mission. This includes projects applying AI in biotechnology, quantum computing, advanced materials, and autonomous laboratories. This initial release precedes a broader Phase I funding opportunity expected later in Fall 2026.
Small Business Innovation Research (SBIR) Program (FY26 Phase I Genesis Mission SBIR/STTR opportunity) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I funding opportunity encourages American small businesses to develop breakthrough technologies aligned with DOE's Genesis Mission across four topic areas: biotechnology, quantum computing and networking, advanced materials, and AI-driven autonomous laboratories.
DOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
Read articleThe DOE Genesis Mission RFA closed its Phase II window on May 19. With $293.76M, 21 topics, and 99 focus areas, it is the largest single federal AI-for-science procurement in 2026. Here is what survived the cut and what comes next.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
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