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Transforming Science and Energy with AI (FY26 Phase I and Phase II) is sponsored by Department of Energy (DOE) Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO).
This funding opportunity from the Department of Energy encourages interdisciplinary teams to address National Science and Technology Challenges by accelerating scientific discovery and R&D workflows using novel AI models and frameworks.
While the primary focus areas are broad (e.g., advanced manufacturing, biotechnology, discovery science), AI and machine learning for large-scale imaging data analysis is relevant across scientific fields and could potentially include biomedical applications, making it a broader but still relevant option for universities with strong AI and scientific computing programs.
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Or search similar grants →According to the current listing, eligibility includes: Interdisciplinary teams from DOE/National Nuclear Security Administration (NNSA), National Laboratories, U.S. industry, and academia are encouraged. Confirm the full requirements in the official notice before applying.
Transforming Science and Energy with AI (FY26 Phase I and Phase II) is funded by Department of Energy (DOE) Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
On July 20, 2026, the EDA announced it intends to invest $169 million across six Regional Technology and Innovation Hubs — quantum, nuclear, critical minerals, biosecure manufacturing, pharmaceuticals, and forest bioproducts — after the Trump administration rescinded the Biden-era Phase 2 awards and reran the competition. Only two of the original winners survived. Here is the full breakdown of the six hubs, why four prior awardees were dropped, and what the re-award teaches regional coalitions about competing for the next round.
Read articleOn August 24, 2026, DOE and SBA signed a memorandum of agreement creating the Small Business Investment Company-Energy Initiative, pointing a $58 billion SBA-leveraged investment program at DOE's technology priorities. No application, no NOFO, no deadline. Here is how SBIC capital actually works, why a January 2026 rule change made this possible, and what a company sitting on a DOE Phase II award should do about it.
Read articleThe Hydrocarbons and Geothermal Energy Office's University Training and Research program funds coal, oil and gas, and geothermal R&D at U.S. colleges and universities — but every proposal must include a non-academic partner and must build training modules that outlive the award. The LOI deadline is October 1, 2026, with full applications 15 days later. Here is what that compressed window means and why the workforce framing changes what a competitive proposal looks like.
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