Understanding the Rules of Life: Epigenetics

IA Resilience call reinforcing Europe's strenght in health is sponsored by European Commission — Horizon Europe. Expected Outcome: the proposals under this call are expected to address one or more of the following subjects : • Enhanced personalized monitoring, care and treatments, focusing on the development of highly customized healthcare solutions, including the required research and diagnostic tools, tailored to individual needs, covering various scenarios such as chronic disease management, physiotherapy, precision diagnosis, personalized medicine/treatment, pre- and postoperative care, and daily assistance in homes and common spaces. It also targets effective management of chronic diseases and elderly care through personalized monitoring and interventions facilitated by advanced sensor technologies and edge-to-cloud solutions. This includes the development and integration of solutions for Hospitalization at Home, enabling patients to receive complex, remotely supervised care using intelligent medical devices capable of sensing, analysing, and transmitting real-time data. This requires a continuum, from in-hospital diagnostics to robust, long-term patient support at home via AI-driven care pathways and hospitalization at home. • Prevention and treatment of diseases, allowing the improved scientific understanding, early detection and proactive prevention of diseases through scientific research, continuous monitoring, predictive analytics, and timely alerts, possibly powered by AI algorithms. This preventive approach enables early intervention and significantly reduces risks associated with many illnesses such as viral infections (e.g. epi- and pan demics), cardiovascular diseases, diabetes complications affecting the health of the young and old. • Efficient, scalable, and cost-effective healthcare, demonstrating how ECS-based technologies can streamline clinical workflows, reduce administrative burdens, and improve resource allocation in healthcare systems. This includes automation and intelligent operations management across clinical, diagnostic, and homecare settings, ultimately improving cost-effectiveness and scalability. • Secure and compliant healthcare continuum, including solutions that ensure robust data protection and regulatory compliance (e.g. GDPR), particularly in handling sensitive health data. Projects should adopt privacy-by-design principles and implement secure data handling architectures using localized edge computing, encryption, authentication, and anonymization strategies within both clinical and assisted living environments. • Seamless interoperability across devices, systems, and platforms, addressing the integration of heterogeneous systems across the edge-to-cloud continuum. Solutions should rely on open standards and modular architectures to ensure interoperability, flexibility, and adaptability across various healthcare settings and use cases, fostering a unified European health-tech ecosystem. Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Digital, Industry and Space

Understanding biomass flows in Europe is sponsored by European Commission — Horizon Europe. Expected Outcome: Project results are expected to contribute to all the following expected outcomes: enhanced understanding of the environmental, social and economic potential of the supply of different biomass types (from local to international perspectives), as well as its sustainability implications, including biodiversity and (air, water and soil) pollution, synergies and tensions; enhanced capacity of private and public stakeholders to increase resource efficiency in utilising primary and secondary biomass as well as biomass processing and use, including through digital tools which may involve artificial intelligence and remote sensing, and roadmaps towards sustainable biomass management; without undermining food security; enhanced support to businesses and administrations that optimise biomass supply, processing, and use, such that ecosystems and biodiversity are protected and restored, emissions of greenhouse gases and pollutants reduced, and human needs for biomass satisfied in sufficient and fair way. Scope: There is a need to better understand the production and use of biomass, a limited resource, in its various types. Bioeconomy, and biomass as its essential feedstock, provides solutions on various dimensions (environmental, social and economic). However, there are biomass-related challenges to overcome: the EU forest carbon sink is below the target and declining in most countries and the need to restore ecosystems and halt biodiversity loss [1] . This implies that biomass supply is partly unsustainable. Simultaneously, companies see themselves challenged to satisfy the growing demand for biomass in the future. There are solutions to increase the sustainable production, including to reduce pollutants, and adjust the demand: e.g. better valorise unused or under-exploited sustainable biomass and degraded land, apply new breeding techniques and increase resource efficiency through circular design, new business models, consumption, recycling or repair. There is a need to better understand where biomass valorisation can be improved, to ensure local or regional added value increases and to drive innovative and competitive business solutions. For an optimal biomass production and effective use, matching supply and demand in the local or regional context, a better and more robust understanding of actual biomass flows is a fundamental prerequisite. Proposals should address all the following activities: Improve and develop innovative, administration-light biomass monitoring and modelling/assessment methods and digital tools at European level (regional, national, and continental scale) to optimise biomass flows, paying particular attention to areas with untapped (sustainable) biomass resources, in close cooperation with stakeholders. Provide an updated estimate of biomass supply and demand today and projected until 2050 at national and EU level, including associated countries, considering the quality of biomass, their potential use, the sustainability and risks (e.g. spread of pathogens) of supplied biomass, as well as potential non-satisfied (non-)industrial demand due to the limitation of availability of sustainable biomass. The 2050 outlook should be accompanied by scenarios on EU’s future bioresources regarding supply and demand. Test and demonstrate, in cooperation with stakeholders, the feasibility of biomass reporting in test regions of at least 10 countries across Europe with different potential of biomass supply. The European Commission’s Joint Research Centre (JRC) may participate as member of the consortium selected for funding since the monitoring and assessment tools developed may contribute to the EU level assessment of biomass flows of the Knowledge Centre for Bioeconomy. Proposals are encouraged to work together with additional relevant initiatives including those of the Circular Biobased Europe Joint Undertaking, the European Circular Economy Stakeholder Platform, the BIOEAST Initiative; build on results from Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy Keywords: Bioeconomy, Blue Economy, bio-economies, bio-economy, bioeconomies, bioeconomy, biological, biomass, circular, flows, hub, materials, region, renewable, resource, resources, sustainability, sustainable