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This program will advance scientific community datasets to enable scientific discovery and innovation using artificial intelligence (AI) and other methods. Its goal is to increase the value that can be derived from existing scientific datasets by leveraging novel methods and artificial intelligence (AI). This will unlock new AI-driven insights. It can enable interdisciplinary research. It also enables investigations outside of the original motivation for data collection and analysis.The program seeks to 1) apply AI-based capabilities to feature extraction and metadata generation, and the integration of multiple datasets. 2) Develop robust data pipelines necessary for automated analysis of existing datasets and similar use-cases by AI tools and systems. 3) Augment and/or harmonize existing datasets to better enable use by AI data pipelines and automated analysis. Proposals should address dataset security and integrity. Governance and the process for scientific communities to contribute to the datasets should also be addressed. Proposals are encouraged to leverage existing resources. These may include NSF data platforms, the NSF Integrated Data Systems and Services program, the NSF-led National AI Research Resource, the Genesis Mission platform, or other national infrastructure.NSF is open to exploring partnerships with philanthropy, private industry, or the non-profit sector to support additional proposals or collaborative opportunities that will advance AI-driven scientific discovery through unlocking the value of high-impact scientific datasets.Expanding Participation in STEM, NSF Priorities, and Gold Standard Science:NSF prioritizes cutting-edge discovery science and engineering research, advancing technology and innovation, and creating opportunities for all Americans. NSF has established priorities set forth by Congress, the administration and the NSF director to promote NSF's mission. Proposers should review the list of NSF priorities and are encouraged to align their proposals with them, where appropriate. NSF also expects the highest standards of scientific rigor, integrity and adherence tenets of Gold Standard Science in proposals, as appropriate for the field of science and research modality.
Funding Opportunity Number: 26-512. Assistance Listing: 47.041,47.049,47.050,47.074,47.084. Funding Instrument: G. Category: ST. Award Amount: $100M total program funding.
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Or search similar grants →According to the current listing, eligibility includes: Eligible applicants: Others (see text field entitled Additional Information on Eligibility for clarification). *Who May Submit Proposals: Proposals may only be submitted by the following: -For-profit organizations: U.S.-based commercial organizations, including small businesses, with strong capabilities in scientific or engineering research or education and a passion for innovation. -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Other Federal Agencies and Federally Funded Research and Development Centers (FFRDCs): Prospective proposers from other Federal Agencies and FFRDCs, including NSF sponsored FFRDCs, must follow the guidance in PAPPG Chapter I.E.2 regarding limitations on eligibility. -State and Local Governments -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus. -Tribal Nations: An American Indian or Alaska Native tribe, band, nation, pueblo, village, or community that the Secretary of the Interior acknowledges as a federally recognized tribe pursuant to the Federally Recognized Indian Tribe List Act of 1994, 25 U.S.C. §§ 5130-5131. Confirm the full requirements in the official notice before applying.
The current listing shows $100M total program funding. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Unlocking Dataset Value for AI-Enabled Scientific Discovery (AI Datasets) are due November 3, 2027. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Yes — Unlocking Dataset Value for AI-Enabled Scientific Discovery (AI Datasets) is offered by U.S. National Science Foundation and this listing comes from Grants.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
This opportunity targets applicants in Alaska. If your organization operates elsewhere, check the official notice for location requirements.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
NSF Unlocking Dataset Value for AI-Enabled Scientific Discovery is sponsored by National Science Foundation (NSF). This new program aims to advance scientific community datasets and enable discovery and innovation using artificial intelligence and other methods in national priority areas. It focuses on increasing the value of existing scientific datasets rather than primarily supporting new data collection, to enable new AI-driven insights and interdisciplinary research.
Fast Grants are lightweight, fast-turnaround gifts for researchers who want to explore an idea at the intersection of AI and health but lack the seed capital to try, and the programme is built around speed as its defining feature: roughly two weeks from deadline to decision. Cycle 1 of 2026 closed 15 June with decisions by 1 July; Cycle 2 closes 15 December 2026 at 11:59pm PT, with decisions around 1 January 2027 and funding approximately 1 February 2027. The foundation organises its interest around two pillars - AI-driven diagnostics and prediction, and personalised therapeutics and autonomous research - but the eligible project list is deliberately wide: training, fine-tuning or evaluating models on biomedical data; exploring or assembling datasets that could unlock new clinical or biological insight; building AI tools or agents that scale a scientist's leverage; and pilot experiments that de-risk a bigger funding ask. That last category is the strategic one. A Fast Grant is explicitly positioned as the preliminary-data vehicle for a subsequent NIH R01 or foundation application, and proposals that name the larger grant they are de-risking read well. The application itself is unusually short - seven bullet-pointed sections with character limits covering title, one-sentence summary, research question, methodology, team background, budget and intended outputs - so the effort-to-expected-value ratio is among the best available in biomedical AI funding.
NSF 27-500 replaces the MRI solicitation: no per-institution limit, no tracks, $50 million for about 60 awards, and a January 4–29, 2027 window. What changes for research offices.
Read articleOn October 28, 2026, NSF sent its revised Guidance on Financial Assistance to OMB after 3,277 public responses. The revision drops four provisions borrowed from OMB's unfinished 2 CFR 200 rewrite: no fixed-price awards, no publication costs, termination for convenience, and indirect costs subject to available funds. The final 30-day comment period runs through about November 27. Here is what changed, what didn't, and what research offices should do before the December 11 funding cliff.
Read articleNSF 26-022, the July 8, 2026 Dear Colleague Letter last updated October 27, says NSF will prohibit its funds from supporting research collaborations with entities on U.S. restricted-party lists in FY2027, on the same timeline as the Guidance on Financial Assistance. Authorized organizational representatives and senior/key personnel will certify compliance at proposal submission. Here is what is covered, what is still undefined, and a 60-day plan for research offices and PIs.
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