Vertex Innovation Awards (VIA) is a grant program from Vertex Pharmaceuticals that funds innovative and collaborative clinical research projects focused on cystic fibrosis. Up to four projects are selected annually, with total funding of up to $750,000 USD distributed across selected projects.

The program seeks researchers with established career interest in cystic fibrosis who are leading clinical research with a significant potential for patient impact. Eligible applicants are individuals or research teams conducting CF-focused clinical research. Applications are evaluated on scientific merit, innovation, collaboration, and relevance to advancing cystic fibrosis outcomes.

Funding is provided as a research grant through Vertex's investigator-sponsored studies program.

# Vertex Pharmaceuticals | Responsibility | Investigator Sponsored Studies, Grants, and Sponsorships Don't see your region/country listed? Visit our global website ###### Living Our Culture, Delivering For Patients Chief Human Resources Officer Stephanie Franklin discusses our unique culture at Vertex and how we bring our culture to life.

Learn more ###### Rethinking Education and the Future of Work Meet three students who flourished in our 2024 Learning Lab summer internship programs in Boston, San Diego and Oxford, U.K. Learn more ###### Record-breaking: Our 17th annual Global Week of Service Join us as we celebrate 17 years of giving back at Vertex.

Learn more * Clinical Trials and Data Sharing ###### R&D Pipeline Our scientists don’t see the impossible as an obstacle; they see it as a good place to start Learn more ###### R&D Locations See where our scientific discoveries happen Learn more ###### Find a Vertex Clinical Trial Volunteers who participate in clinical trials help make new medicines a reality Learn more * Reporting Adverse Events and/or Product Complaints ###### Early Access Information about our Early Access program and how we evaluate requests Learn more ###### CF Facts and Figures Facts about cystic fibrosis (CF), including prevalence and the numbers of people with CF around the world estimated to be on CFTR modulators Learn more ###### Reporting Adverse Events and/or Product Complaints Instructions on how to submit a report Learn more ###### Kidney Diseases We work with the kidney disease community to ensure their voices are represented in all that we do Learn more ###### Sickle Cell Disease See how we're engaging with the sickle cell disease community Learn more ###### Find a Vertex Clinical Trial Volunteers who participate in clinical trials help make new medicines a reality Learn more * Environmental Sustainability * Vertex Volunteers and Employee Giving * Investigator Sponsored Studies, Grants, and Sponsorships * Reports, Position Statements and Programs ###### Our STEAM Commitment Discover how we're inspiring and equipping the next generation to love science and pursue a career in STEM Learn more ###### Environmental Sustainability Explore our commitment to limiting our environmental impacts and operating our business in a sustainable manner Learn more * Career Growth and Opportunities * Innovation and Education * Rewards and Recognition ###### Caring For Our People; Helping Improve Lives Chief Human Resources Officer Stephanie Franklin discusses Vertex’s inclusive benefits and how they are helping Vertexians.

Learn more ###### Benefits We're continually adapting our benefit offerings to support our unique culture. Learn more ###### Career Growth and Opportunities We invest in each of our employees so they can continue to grow and thrive professionally. Learn More * [](https://www.

vrtx. com/en-global) / Responsibility / Investigator Sponsored Studies, Grants and Sponsorships # Investigator Sponsored Studies, grants and sponsorships Vertex funds a variety of programs in the countries in which we operate to educate health care professionals, strengthen scientific research, encourage innovation and fulfill unmet needs in the community.

Vertex is committed to funding programs and initiatives that advance the knowledge and care for people around the world living with cystic fibrosis and other serious diseases where we focus our research. Vertex supports independent research, educational programs and initiatives aimed at educating health care professionals, patients, caregivers and the scientific community.

We also provide organizational sponsorships and corporate memberships to fund programs and initiatives for leading scientists, researchers, doctors and public health experts who share our vision for transforming the lives of people with serious diseases, their families and society.

Vertex will not consider requests from organizations that discriminate on the basis of race, gender, sexual orientation, marital status, religion, age, national origin, veteran status or disability. Learn more about our external funding process by reading our Common Questions and Funding Information or visiting the Vertex Request Management System by clicking one of the "Learn More and Apply" buttons below.

Common Questions and Funding Information ## Investigator Sponsored Studies We offer Investigator Sponsored Studies to fuel the next generation of researchers who want to dedicate their careers to improving the lives of people with serious diseases.

We work with leading researchers, doctors, public health experts and other collaborators who share our vision for transforming the lives of people with serious diseases, their families and society.

Our **Investigator Sponsored Study** program supports independent, investigator-sponsored research designed to advance scientific knowledge of disease states, patient populations and medical treatments that align with our clinical and scientific areas of interest.

We consider funding and/or drug support for the following categories of research: * Clinical studies investigating a specific intervention * Observational studies evaluating a disease state (e.g., epidemiological and outcomes studies) * Nonclinical studies using Vertex compounds for _in vitro_ assays or _in vivo_ models We review Investigator Sponsored Study requests related to: * Beta thalassemia and sickle cell disease * _Please note, Vertex is only accepting applications in response to an RFP_ * _Please note, Vertex is only accepting pain study proposals in the U.S._ We review applications for the following areas: * Studies involving approved Vertex medicines Beta thalassemia and sickle cell disease * Impact of exa-cel on cerebrovascular outcomes including hemodynamics in patients with sickle cell disease * Patient factors and/or preparation (e.g., transfusion regimen or concomitant therapies) impacting hematopoietic stem cell mobilization and collection in sickle cell disease and/or thalassemia For beta thalassemia and sickle cell disease, Vertex is currently not prioritizing applications for: * Prospective clinical trials or interventional studies with exa-cel * Use of alternative conditioning regimens in patients treated with exa-cel * Studies measuring quality of life and/or patient-reported outcomes in patients treated with exa-cel * Evaluation of biomarkers and outcome measures of CFTR function in patients with CF on CFTR modulators * Disease modification with CFTR modulators including living longer * Impact of treatment with CFTR modulators early in disease course * Non-pulmonary effects of CFTR modulators * Impact of CFTR modulator use on patient and caregiver burden _Vertex is currently prioritizing applications for vanzacaftor/tezacaftor/deutivacaftor.

_ For cystic fibrosis, Vertex is currently not prioritizing applications for: * Therapeutic drug monitoring * Drug-drug interaction (DDI) studies * Biomarkers & risk factors * Patient reported endpoints * Kidney biopsy & imaging * Gd-IgA1 antibodies, anti-Gd-IgA1 autoantibodies, and immune complexes For IgA nephropathy, Vertex is currently not prioritizing applications for: * Therapeutic drug monitoring * Drug-drug interaction (DDI) studies * Response-guided therapy * Studies to evaluate impact on opioid prescription and utilization, including impact on hospitalization, length of stay, and/or Opioid Related Adverse Events (ORADES).

​ * Suzetrigine use patterns, effectiveness, and other attributes in real-world multimodal setting​ * Effect of suzetrigine in different acute pain settings/procedures * Natural history and real-world practice patterns and outcomes in pain * Innovative ways to capture clinical effectiveness and safety in the real world (e.g., case series, novel endpoints, retrospective studies) Pain procedures/conditions prioritized for applications: For pain, Vertex is currently not prioritizing applications for: * Therapeutic drug monitoring * Drug-drug interaction (DDI) studies * Response-guided therapy * Prospective randomized controlled trials * Studies on acute pain related to migraines * Active cancer studies, or in cancer patients actively taking or anticipated to take future chemotherapeutics * All chronic pain conditions Learn moreReady to submit?

Apply here We support enhancing medical and scientific knowledge and patient education to improve overall care for patients.

In the areas where our research is focused, we consider requests from organizations for grants related to: Independent medical education programs (accredited and non-accredited) * We review grant requests related to: * APOL1-mediated kidney disease Patient education and advocacy programs, projects and initiatives * We review grant requests related to: * APOL1-mediated kidney disease (U.S. only) Vertex is committed to supporting the medical, scientific and local nonprofit communities through sponsorships of meetings, events or other initiatives in exchange for tangible benefits, such as exhibit space, tickets or registration to a funded meeting or event or other forms of recognition.

We review requests for sponsorships, exhibits and corporate memberships related to: * APOL1-mediated kidney disease * Autosomal dominant polycystic kidney disease * Duchenne muscular dystrophy * Myotonic dystrophy type 1 ## Cystic fibrosis (CF) award programs Vertex offers three competitive grant programs focused on advancing scientific and clinical research in the field and in support of the CF community.

Circle of Care is a global competitive grant opportunity that funds innovative patient-centric programs for the CF community. Each grant cycle, Vertex awards programs that support people with CF to live fuller, more engaged lifestyles. An independent steering committee, comprised of individuals who are part of the CF community, selects the recipients.

The submission period for the Circle of Care program is closed. The next award cycle will open in late summer/early fall. For more information, please contactvertex_grants@vrtx.

com. ## CF Research Innovation Awards Vertex CF Research Innovation Awards (RIA) are highly competitive grants created to inspire and support the next generation of M. D.

s and Ph. Ds. who are working to advance the understanding of CF and establish their careers as CF researchers.

There are two categories of awards: Independent Research and Mentored Research. Applications are reviewed and selected by an independent steering committee. * **Independent RIAs** provide grants of $750,000 USD distributed over three years to support newly independent faculty members as they establish their own research programs with outstanding promise in CF.

Up to two awards are given annually. * **Mentored RIAs** provide grants of up to $125,000 USD distributed over two years to support mentored projects with established CF researchers. Up to four awards are given annually.

The submission period for the RIA Awards program is closed. For more information, including the next application cycle, please contactRIAProgram@vrtx. com.

## Vertex Innovation Awards Vertex Innovation Awards (VIA) support innovative and collaborative clinical research aimed toward improving the care of people with CF. Applications for clinical research projects are welcomed from across the entire field of CF and are to be led by an individual or individuals who have established their career interest in CF. Each year, Vertex awards up to $750,000 USD to four selected projects.

Applications are reviewed and selected by an independent committee of experts outside of Vertex. The submission period for the VIA Awards program is closed. For more information, including the next application cycle, please contactVIAProgram@vrtx.

com. ##### News Stay current on all things Vertex and discover the latest news, information and updates on our company. _Intended for media_ ##### Investors Through our transformative medicines for patients, we drive value for our company, shareholders and society.

##### Stories Discover more about our relentless efforts to improve the lives of patients, employees and our communities. You are about to leave the Vertex website. Vertex assumes no responsibility for information or statements you may encounter on the Internet outside of Vertex's website.

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