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The Wellcome Prize for Mental Health Science with Nature is the world's largest global prize for mental health science, launched by Wellcome Trust in partnership with Nature in May 2026. The prize recognizes and supports breakthrough advances for anxiety, depression and psychosis that deliver measurable health impact.
The award explicitly champions digital and AI-based interventions alongside new pharmacological, psychological, and social interventions from around the world.
AI-relevant categories include: digital therapeutics powered by AI, generative AI for mental health interventions, AI clinical decision support for mental health, digital biomarkers and machine learning for early detection, AI-driven personalized treatment matching, and software-based scalable interventions.
Entries are assessed by an expert panel against four core criteria: novelty, credibility, effectiveness, and adoptability, alongside the strength of lived experience engagement. The overall winner receives USD 1 million, and three finalists each receive USD 250,000 to support continued development.
The prize complements Wellcome's existing $30M+ portfolio supporting Mental Health Awards for digital interventions and generative AI for anxiety, depression, and psychosis research.
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Or search similar grants →According to the current listing, eligibility includes: Open globally to researchers, clinicians, technologists, startups, and organizations who have developed evidence-based interventions for anxiety, depression, or psychosis. Eligible entries include digital therapeutics, AI-driven tools, software interventions, pharmacological compounds, psychological therapies, and social interventions. Multidisciplinary teams encouraged. Strong emphasis on lived experience engagement throughout development. Interventions must demonstrate evidence of effectiveness and potential for scaling and adoption. Confirm the full requirements in the official notice before applying.
The current listing shows overall winner receives $1,000,000 USD. Three finalists each receive $250,000 USD. Total prize pool of $1,750,000 USD. Funds support continued development, validation, and scaling of the recognized intervention. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Wellcome Prize for Mental Health Science with Nature Recognizing Digital and AI Mental Health Innovations are due September 30, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Wellcome Prize for Mental Health Science with Nature Recognizing Digital and AI Mental Health Innovations is funded by Wellcome Trust in partnership with Nature (Springer Nature). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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