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LOI due August 8, 2025 by 8pm ET. Full application by invitation after LOI review. Stored deadline was null.
"Wiedemann-Steiner Syndrome Foundation Grant Program 2025" is currently closed and not accepting applications.
Wiedemann-Steiner Syndrome Foundation Grant Program 2025 is sponsored by Wiedemann-Steiner Syndrome Foundation (through University of Pennsylvania Orphan Disease Center). This program provides 2-year grants to support research related to Wiedemann-Steiner Syndrome (WSS), a rare genetic disorder caused by mutations in the MLL gene.
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The Wiedemann-Steiner Syndrome Grant Program 2025 — Orphan Disease Center The Wiedemann-Steiner Syndrome Grant Program 2025 The Wiedemann-Steiner Syndrome The Wiedemann-Steiner Syndrome Foundation will provide 2-year grants to support research related to Wiedemann-Steiner Syndrome. At least 3 awards will be granted.
Wiedemann-Steiner Syndrome (WSS) is a rare genetic disorder resulting from mutations in the MLL gene (also known as KMT2A) on the long arm of chromosome 11. The syndrome’s genetic underpinnings were clarified in 2012 by a group of researchers led by Dr. Wendy Jones. The gene encodes a histone methyl transferase which helps modify the expression of many other genes.
The condition is autosomal dominant, and in most cases, the mutation occurred de novo. From an unpublished survey of 76 WSS families, the symptom determined to be of “Very High Impact” by most families, was disruptive behaviors. This included aggressive behaviors, impulsivity, and behaviors outside of age-appropriate societal norms and the most important therapeutic goals were to reduce these behaviors and improve cognitive functioning.
The Orphan Disease Center, in collaboration with the WSS Foundation, is seeking grant applications that aim to further progress the understanding of the disease: Two $90,000 grants to support the development and characterization, for the advancement toward therapeutic goal, of patient-derived cell models of WSS Syndrome (ex. iPSCs, neurons, reporter lines). These cells model will be deposited into a publicly accessible biobank.
One $90,000 grant to support a Natural History Study. Proposals for this grant should focus on understanding the progression of the condition over time, often to support product development, especially for rare diseases. These studies are observational and aim to identify factors that influence disease development and outcomes.
All individuals holding a faculty-level appointment at an academic institution or a senior position at a non-profit institution or foundation are eligible to respond to this RFA. Letters of Interest (LOI) are due Friday, August 8, 2025 by 8pm ET. Please review the WIEDEMANN-STEINER SYNDROME FOUNDATION 2025 GRANT PROGRAM RFA Guidelines.
Complete the Application Form on Submittable. For any scientific inquiries regarding this grant please email Debbie Requesens For any administrative inquiries regarding this grant please email psom-odcadmin@pobox. upenn.
edu Posted In: 2025 , Wiedemann-Steiner Syndrome Tagged: JumpStart , 2025 , Wiedemann-Steiner Syndrome JACK BEAR FOUNDATION 2025 GRANT PROGRAM - Full Application (by invitation only) APBD RESEARCH FOUNDATION 2025 PILOT GRANT PROGRAM
According to the current listing, eligibility includes: Faculty-level appointment at an academic institution or senior position at a non-profit institution or foundation; international applicants eligible. Confirm the full requirements in the official notice before applying.
The current listing shows $90,000 per award. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was August 8, 2025, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Wiedemann-Steiner Syndrome Foundation Grant Program 2025 is funded by Wiedemann-Steiner Syndrome Foundation (through University of Pennsylvania Orphan Disease Center). Verify program details on the funder's official page before applying.
This listing is flagged as international in scope. Check the official notice for country-specific restrictions before applying.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
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