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2026 Clinical and Translational Science AI Innovation (CTS-AI) Award RFA is sponsored by The Ohio State University (through CTSI). This funding opportunity supports the development of new concepts, methods, and projects in clinical and translational science using AI. It aims to foster innovation and facilitate the application of AI in health outcomes, with an emphasis on interdisciplinary collaboration.
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2027 Clinical and Translational Science AI Innovation (CTS-AI) Award RFA | Clinical and Translational Science Institute 2027 Clinical and Translational Science AI Innovation (CTS-AI) Award RFA Please read all of the RFA instructions below before submitting your application. Up to $125,000 per year in direct costs can be budgeted for a two-year period, for a maximum amount of $250,000.
Carryover and no-cost extensions are not allowed, thus unspent funds become unavailable after 12 months. Salary support for faculty may be requested under the following guidelines: Assistant Professor 15% effort up to NIH CAP Associate professor 10% effort up to NIH CAP Full professor 5% effort up to NIH CAP Salary and fringe support are permitted for students, graduate students, clinical trainees, post-doctoral, and clinical fellows.
Subcontracts are not allowed for personnel or services outside Ohio State or Nationwide Children’s Hospital. Travel funds are permitted if necessary to conduct the study (e.g., participant travel). International travel is not allowed.
Equipment may be requested that is essential for the study and not otherwise available, but equipment expenditures greater than $3,000 are discouraged. Awards include in-kind support for disseminating validated methods across the regional and national CTSA networks for broader translational science impact. MPIs must have Principal Investigator (PI) status with Ohio State or Nationwide Children’s Hospital.
MPIs cannot have had a CTSI pilot award that activated on or after Aug. 1, 2025, or a CTS-AI Award that activated on or after Aug. 1, 2024.
For pre-applications invited for full applications, before submitting their full applications: MPIs must be members of CTSI. Click here to join CTSI . All project personnel must complete all necessary research training for proposed projects involving human subjects (Responsible Code of Research, Human Subject Protection and Good Clinical Practice).
CTS-AI proposals must include an innovative AI/data science approach/technology that drives translational science and should clearly identify the translational research challenges or barriers that it addresses. Pre-clinical projects are not eligible. Proposed work must be innovative, equitable and generalizable.
Proposed work must be completed within two years. The NIH does not allow carryover or no cost extensions on these funds. Feasibility for completing the work within 24 months is an important review criterion.
Application and Review Process A pre-application is required and must be submitted via REDCap in the following format: Translational Science Statement Regulatory Considerations 1-Page Abstract of the proposed work that includes the translational science-directed research question, translational research challenge(s) addressed, significance, methods, and specific aims Pre-applications will be evaluated by CTS-AI Award co-directors for significance, innovation, and relevance to CTSI’s mission, and selected pre-applicants will be invited to submit full applications.
Full applications are by invitation only. CTSI participates in a national Center for Translational Science Award External Reviewer Exchange Consortium to improve fairness in the scientific review process and better match applicants with feedback from experts in their respective fields. Trained patient and practitioner reviewers are also included in the grant review process.
In submitting your application, you agree to allow access to your application to reviewers external to The Ohio State University and Nationwide Children’s Hospital. Applications are reviewed by 1-2 scientific reviewers with subject matter expertise and 1 community reviewer, utilizing the NIH 9-point scale.
They are then assessed in an NIH-style study section that considers reviewer feedback on significance, rigor and feasibility, and translational and overall impact; institutional context; and relevance to CTSI’s mission. Projects selected for a CTSI award must obtain NCATS prior approval—which requires IRB approval or determination of non-human subject research—before funds can be released.
The awarded team must meet with CTSI’s Regulatory Program Manager before March 15, 2027, and submit to IRB by March 31, 2027, or the offer for funding will be withdrawn. Optional Information Session The award program’s co-directors and program manager will host an optional information session that includes Q&A time for participants. Virtual.
Optional Ideation Workshop Prospective applicants have the opportunity to present proposal ideas in a virtual workshop designed to elevate the strength and quality of proposals through early peer and panel feedback. Submission Window for Pre-Applications Opens Pre-applications are mandatory.
Mandatory Pre-Applications Due Submission window opens September 28, 2026 Invitations to Submit Full Application Late applications will not be accepted. Notifications will be sent out. Mandatory Consult with CTSI Regulatory Program Manager Due Regulatory Program Manager: April Green Late submissions will not be accepted.
NCATS Prior Approval Documents Due to Regulatory Manager Regulatory Program Manager: April Green Contingent upon NCATS prior approval.
According to the current listing, eligibility includes: Applicants must have Principal Investigator (PI) status as defined by The Ohio State University or Nationwide Children's Hospital and be members of CTSI. Confirm the full requirements in the official notice before applying.
The current listing shows up to $125,000 per year for two years (maximum $250,000). Verify award ceilings, matching requirements, and allowable costs in the official notice.
2026 Clinical and Translational Science AI Innovation (CTS-AI) Award RFA is funded by The Ohio State University (through CTSI). Verify program details on the funder's official page before applying.
This opportunity targets applicants in Ohio. If your organization operates elsewhere, check the official notice for location requirements.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
HCU Global Grants Program is sponsored by HCU Network America. HCU Network America provides research grants to support novel proposals for the treatment and prevention of clinical manifestations for Classical Homocystinuria and/or Cobalamin G, a Methionine Synthase deficiency. These grants are intended to support innovative seed or pilot projects to produce preliminary data that would facilitate more substantial funding from federal agencies, foundations, or corporations. An Expression of Interest (EOI) was due May 31, 2026, with full applications due August 31, 2026, and funding decisions by October 31, 2026.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Broad Pragmatic Studies PCORI Funding Announcement – Cycle 2 2026 is a grant from the Patient-Centered Outcomes Research Institute that funds large-scale, high-impact patient-centered comparative clinical effectiveness research (CER). PCORI invites proposals for pragmatic randomized controlled trials, natural experiments, and well-designed observational studies that address clinically meaningful outcomes important to patients. Awards reach up to $12,000,000 in direct costs for Categories 2-3, and up to $5,000,000 for Category 1. Proposals must align with PCORI's Foundational Expectations for Partnerships in Research. The Letter of Intent deadline is April 28, 2026, and the full application deadline is September 1, 2026.
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