Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed)

Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) is sponsored by NIH Common Fund. This program encourages applications for outstanding research in epitranscriptomics, focusing on the chemical modifications of RNA and their roles in developmental processes and disease states.

Funded Research | NIH Common Fund Please note this webpage is being maintained as an archive and will not be updated on a regular basis.

Extracellular RNA Communication (ExRNA) Extracellular RNA Communication (ExRNA) NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-21-151 PI Name Institution Name Title KASHANCHI, FATAH GEORGE MASON UNIVERSITY American Society for Intercellular Communication (ASIC) Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-028 In September 2021, the awards below transitioned into their UH3 phase.

The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on demonstrating isolation effectiveness using human biofluids.

PI Name Institution Name Title CHIU, DANIEL T UNIVERSITY OF WASHINGTON Single Extracellular Vesicle Sorting and Analysis DAS, SAUMYA (contact) VAN KEUREN-JENSEN, KENDALL MASSACHUSETTS GENERAL HOSPITAL Molecular dissection and imaging of extracellular vesicles to define their origin and targets GHIRAN, IONITA CALIN (contact) MILOSAVLJEVIC, ALEKSANDAR BETH ISRAEL DEACONESS MEDICAL CENTER Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry REATEGUI, EDUARDO (contact) KIM, YON SON BETTY OHIO STATE UNIVERSITY Microfluidics Array Based Sorting, Isolation, and RNA Analysis in Single Extracellular V csicles ROUTENBERG, DAVID AARON MESO SCALE DIAGNOSTICS, LLC Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures WONG, DAVID T (contact) XIE, YA-HONG UNIVERSITY OF CALIFORNIA LOS ANGELES Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids Advancing Extracellular RNA (exRNA) Communication Research: Improved Isolation and Analysis of exRNA-Carrier Subclasses (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-027 In September 2021, the awards below transitioned into their UH3 phase.

The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on UH3 optimizing, refining, and scaling-up of validated separation technologies using human biofluids. PI Name Institution Name Title CHANG, HSUEH-CHIA UNIVERSITY OF NOTRE DAME High-Throughput Electrokinetic Fractionation and Analysis of Extracellular RNA Nano-Carriers COFFEY, ROBERT J.

(contact) CHAREST, ALAIN VANDERBILT UNIVERSITY MEDICAL CENTER Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma LAURENT, LOUISE CHANG UNIVERSITY OF CALIFORNIA, SAN DIEGO Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargo RAFFAI, ROBERT (contact) VAN KEUREN-JENSEN, KENDALL NORTHERN CALIFORNIA INSTITUTE/RES/EDU P.

R. I. S.

M: Purification of exRNA by Immuno-capture and Sorting using Microfluidic WITWER, KENNETH W JOHNS HOPKINS UNIVERSITY Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates Data Management and Resource Repository (DMRR) on Extracellular RNA (U54 Clinical Trial Not Allowed) RFA-RM-18-026 PI Name Institution Name Title MILOSAVLJEVIC, ALEKSANDAR (contact) GERSTEIN, MARK BENDER BAYLOR COLLEGE OF MEDICINE DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE EXRNA ATLAS PHASE II NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-18-648 PI Name Institution Name Title HERMANN, THOMAS C UNIVERSITY OF CALIFORNIA, SAN DIEGO 2019 RNA Nanotechnology GRC/GRS Clinical Utility of Extracellular RNA for Biomarker Development (UH2/UH3) RFA-RM-12-013 In 2015, the awards below transitioned into their UH3 phase.

The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the biomarkers.

PI Name Institution Name Title CARTER, BOB S (contact) HOCHBERG, FRED H UNIVERSITY OF CALIFORNIA SAN DIEGO exRNA Biomarkers for Human Glioma DAS, SAUMYA (contact) SABATINE, MARC S BETH ISRAEL DEACONESS MEDICAL CENTER Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI FREEDMAN, JANE E UNIV OF MASSACHUSETTS MED SCH WORCESTER Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease JENSEN, KENDALL(contact) KALANI, YASHAR TRANSLATIONAL GENOMICS RESEARCH INST exRNA signatures Predict Outcomes after brain injury LAURENT, LOUISE C UNIVERSITY OF CALIFORNIA SAN DIEGO ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction PATEL, TUSHAR MAYO CLINIC JACKSONVILLE Extracellular non-coding RNA biomarkers of hepatocellular cancer SAUGSTAD, JULIE ANNE (contact) QUINN, JOSEPH F OREGON HEALTH AND SCI UNIVERSITY Clinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimers Disease TUSCHL, THOMAS (contact) SUTHANTHIRAN, MANIKKAM ROCKEFELLER UNIVERSITY Clinical utility of extracellular RNA as marker of kidney disease progression WEINER, HOWARD L BRIGHAM AND WOMEN'S HOSPITAL Circulating MicroRNAs as Disease Biomarkers in Multiple Sclerosis WONG, DAVID T UNIVERSITY OF CALIFORNIA LOS ANGELES Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection Clinical Utility of Extracellular RNA for Therapy Development (UH2/UH3) RFA-RM-12-014 In August 2015, the awards below transitioned into their UH3 phase.

The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the therapeutics.

PI Name Institution Name Title ABDEL-MAGEED, ASIM, B TULANE UNIVERSITY OF LOUISIANA Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni ARONIN, NEIL UNIV OF MASSACHUSETTS MED SCH WORCESTER Exosome based therapeutics in Huntingtons disease KRAIG, RICHARD P UNIVERSITY OF CHICAGO Exosome RNA-Therapeutics to Promote CNS Myelination MATIN, AC STANFORD UNIVERSITY HER2-targeted exosomal delivery of therapeutic mRNA for enzyme pro-drug therapy QUESENBERRY, PETER J RHODE ISLAND HOSPITAL Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN SCHMITTGEN, THOMAS D (contact) PHELPS, MITCH A UNIVERSITY OF FLORIDA Targeted delivery of microRNA-loaded microvesicle for cancer therapy SOOD, ANIL K (contact) LOPEZ-BERESTEIN, GABRIEL UT MD ANDERSON CANCER CTR Novel extra cellular RNA-based combinatorial RNA inhibition therapy ZHANG, HUANG-GE (contact) GUO, PEIXUAN UNIVERSITY OF LOUISVILLE Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs NIH Support for Conferences and Scientific Meetings (Parent R13/U13) PA-13-347 PI Name Institution Name Title GUO, PEIXUAN GORDON RESEARCH CONFERENCES 2 015 RNA Nanotechnology Gordon Research Conference QUESENBERRY, PETER J GORDON RESEARCH CONFERENCES 2016 Extracellular Vesicles Gordon Research Conference WITWER, KENNETH W JOHNS HOPKINS UNIVERSITY International Society for Extracellular Vesicles - Education Day & Meeting WOODLAND, DAVID L.

KEYSTONE CONFERENCE CENTER Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA (U01) RFA-RM-13-014 PI Name Institution Name Title FREEDMAN, JANE E (contact) ODONNELL, CHRISTOPHER J UNIV OF MASSACHUSETTS MED SCH WORCESTER Racial and Ethnic Diversity in Human Extracellular RNA GALAS, DAVID J.

(contact) WANG, KAI PACIFIC NORTHWEST RESEARCH INSTITUTE Reference Profiles of Extracellular RNA in 4 Body Fluids of Healthy Humans GHIRAN, IONITA CALIN BETH ISRAEL DEACONESS MEDICAL CENTER Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy in healthy individuals LAURENT, LOUISE C UNIVERSITY OF CALIFORNIA SAN DIEGO Reference Profiles of ExRNAs in Normal Human Pregnancy TEWARI, MUNEESH UNIVERSITY OF MICHIGAN AT ANN ARBOR Reference Profiles of ExRNA in Biofluids from Well-Defined Human Cohorts WOODRUFF, PRESCOTT G (contact) ERLE, DAVID J UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA Data Management and Resource Repository (DMRR) on Extracellular RNA (U54) RFA-RM-12-010 PI Name Institution Name Title MILOSAVLJEVIC, ALEKSANDAR (contact) GERSTEIN, MARK BENDER BAYLOR COLLEGE OF MEDICINE Data management and Resource Repository for the exRNA Atlas Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function (U19) RFA-RM-12-012 PI Name Institution Name Title BLELLOCH, ROBERT H UNIVERSITY OF CALIFORNIA-SAN FRANCISCO In Vivo Regulated Release and Function of Extracellular Small RNAs BREAKEFIELD, XANDRA OWENS (contact) MEMPEL, THORSTEN ROMAN MASSACHUSETTS GENERAL HOSP exRNA released by glioblastoma alters brain microenvironment COFFEY, ROBERT J.

VANDERBILT UNIVERSITY MED CTR Secreted RNA during CRC progression biogenesis function and clinical markers MCMANUS, MICHAEL T UNIVERSITY OF CALIFORNIA-SAN FRANCISCO Genetic models for exRNA communication TUSCHL, THOMAS ROCKEFELLER UNIVERSITY Definition of Serum Ribonucleoprotein Composition and its Regulation and Function This page last reviewed on