Advancing the Use of Genomic Information Into Clinical Care

Advancing the Use of Genomic Information Into Clinical Care is sponsored by National Institutes of Health (NIH). This topic promotes research that improves health by generating genomic evidence and/or implementing genomic findings into healthcare, including preventive strategies for managing patients with genomic risk.

Advancing the Use of Genomic Information Into Clinical Care | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health Advancing the Use of Genomic Information Into Clinical Care When beginning your next investigator-initiated application, consider the following NIH highlighted topic. The area of science described below is of interest to the listed NIH Institutes, Centers, and Offices (ICOs).

This is not a notice of funding opportunity (NOFO). Apply through an appropriate NIH Parent Funding Announcement or another broad NIH opportunity available on Grants. gov .

Learn how to interpret and use Highlighted Topics . Post Date: September 10, 2025 Expiration Date: August 29, 2027 This topic seeks to promote research that improves health by generating genomic evidence and/or implementing genomic findings into healthcare. Despite substantial evidence showing genomic variants increase risk for numerous diseases, evidence is limited that using genomic results improves short and long-term outcomes.

This topic addresses this gap by encouraging studies on the impact of genomic information on clinical outcomes while also encouraging research on the most effective methods for implementation of evidence-based genomic medicine interventions into healthcare. Exemplary topics include: 1.

Generating Genomic Medicine Evidence: Pilot Studies: Testing whether use of genomic information improves short-term clinical outcomes or cost-effectiveness, with potential for follow-up to assess long-term impact and real-world application. Outcome Metrics: Developing metrics to evaluate clinical utility, including patient outcomes and cost-effectiveness. Generalizability: Ensuring findings apply across populations and settings.

2. Integrating Genomic Evidence into Clinical Care: Implementation Research: Investigating facilitators and barriers to implementing genomic medicine across a wide range of clinical settings. Frameworks for Study: Identifying, assessing, and applying implementation science frameworks to the study of genomic medicine.

Integration Strategies: Developing and researching strategies to integrate genomic evidence into clinical workflows in ways that optimize health outcomes. Preventive Strategies: Researching preventive strategies to the management of patients with genomic risk while optimizing access, risk, cost, and convenience. 3.

Developing and/or expanding resources relevant to genomic medicine: Clinical resources: defining relevance of genes and variants, developing, implementing, and maintaining genomic-based clinical tools and services for use in genomic medicine.

Translational resources: advancing the creation of repositories of curated multi-omic genetic data to facilitate the investigation of genetic influences on traits, diseases and treatments, enabling better disease prediction, prevention, and therapy strategies.

In summary, this topic promotes innovative research that advances the implementation of genomic information in clinical care, ensuring its benefits are broadly accessible and effectively integrated into routine healthcare. Central Scientific Contact: National Human Genome Research Institute (NHGRI) NHGRI is interested in all of the exemplary topics above.

National Institute of Allergy and Infectious Diseases (NIAID) NIAID is interested in supporting projects that focus on research that advance the use of genomic evidence (human, microbiome, and/or pathogen) to improve clinical diagnosis, care and resolution of infectious diseases, including HIV/AIDS; immunologic and allergic diseases, or organ transplantation; and other areas arising that are relevant to NIAID's scientific mission.

National Institute on Drug Abuse (NIDA) NIDA is interested in studies defining the relevance of genes and gene variants, developing and implementing and maintaining genomic based tools for substance use and addiction.

National Institute of Neurological Disorders and Stroke (NINDS) National Institute of Nursing Research (NINR) The NINR leverages a person-centered holistic nursing perspective to support rigorous solution-oriented research conducted by scientists from any discipline. NINR leads discoveries of innovative systems and models of care, breakthroughs in disease prevention and health promotion, and advances in population and community health.

Our research empowers individuals, families, communities, and populations to optimize their health and well-being. NINR supports research that addresses health differences, intervenes on the conditions in which people live, uses multilevel approaches to prevent disease and promote health, and implements clinical and organizational solutions to maximize positive outcomes of care delivery.

Mary Elizabeth Bowen, PhD Office of Research on Women's Health (ORWH) The areas of interest of the Office of Autoimmune Disease Research in the Office of Research on Women’s Health (OADR-ORWH) include: Develop and use genomic data resources for multilevel approaches to diagnose, prevent, and treat chronic conditions in women. Translate genetic research advancements in women's health across the life course.

Accelerating scientific discovery, developing data science and computational tools to integrate the interactions of genetics with environmental factors for diagnosis, treatment, prevention, and cures, and enhancing health for people with autoimmune disease. This office does not award grants. Applications must be relevant to the objectives of at least one of the participating NIH Institutes and Centers listed in this topic.

Elena Gorodetsky, M. D. , Ph.

D. Victoria Shanmugam, MBBS, MRCP, FACR, CCD National Institute of Dental and Craniofacial Research (NIDCR) Lorena Baccaglini, DDS, MS, PhD, NE-CPhT National Cancer Institute (NCI) Sarah Kalia, PhD, SM, ScM For technical issues E-mail OER Webmaster