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AI for Science Funding Opportunities is sponsored by Department of Energy (DOE) Office of Science. The Genesis Mission: Transforming Science and Energy with AI is a grant from the U. S.
Department of Energy Office of Science that funds small and large teams applying AI to accelerate scientific and energy research.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
According to the current listing, eligibility includes: Not explicitly detailed in the provided snippets, but typically targets research institutions, national laboratories, and universities. Confirm the full requirements in the official notice before applying.
AI for Science Funding Opportunities is funded by Department of Energy (DOE) Office of Science. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Energy Frontier Research Centers (EFRC) program (NOFO: DE-FOA-0003554) is sponsored by U.S. Department of Energy (DOE) Office of Science. This Notice of Funding Opportunity (NOFO) from the Department of Energy's Office of Science aims to accelerate breakthroughs in critical minerals, quantum computing, and advanced manufacturing through fundamental energy technology research.
Energy Frontier Research Centers (EFRCs) (DE-FOA-0003614) is sponsored by U.S. Department of Energy (DOE) Office of Science (SC), Basic Energy Sciences (BES). This program supports fundamental research at Energy Frontier Research Centers to accelerate scientific breakthroughs in areas underpinning energy technologies, including alternative energy. Pre-applications are due April 1, 2026.
Building EPSCoR-State/National Laboratory Partnerships is a grant from Department of Energy (DOE) Office of Science that these partnerships advance understanding of the physical world by supporting fundamental, early-stage energy research collaborations with the DOE National Laboratories. DOE EPSCoR follows NSF EPSCoR Program eligibility determinations. Eligible institutions in EPSCoR states, including universities and research organizations, partnering with DOE National Laboratories. The application deadline is 2026-07-01 00:00:00+00.
The Energy Department's flagship Early Career Research Program is funded at $145M for FY2026 — $79M in current-year dollars, the rest contingent on FY27 appropriations. Full applications are due June 2 from the ~150 researchers DOE pre-cleared in March. Here's what the program rewards, why this year's announcement leans hard into Executive Order 14303 on Gold Standard Science, what untenured PIs at academic institutions vs. national labs should expect, and how to position for the FY27 pre-application gate next March.
Read articleThe DOE Genesis Mission RFA closed its Phase II window on May 19. With $293.76M, 21 topics, and 99 focus areas, it is the largest single federal AI-for-science procurement in 2026. Here is what survived the cut and what comes next.
Read articleDOE's Genesis Mission pairs 24 tech giants — Anthropic, Google, OpenAI, NVIDIA — with national labs to apply AI to 26 grand challenges. Phase II applications close May 19.
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