Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases

Mitochondrial Disease Sequence Data Resource Consortium is a grant from NIH National Center for Advancing Translational Sciences (NCATS) that funds research infrastructure and clinical studies for rare mitochondrial diseases. Administered through the North American Mitochondrial Disease Consortium (NAMDC), a member of the Rare Diseases Clinical Research Network, the program supports a network of 17 clinical centers focused on improving diagnosis and care, establishing natural history, supporting translational research, and investigating treatment for mitochondrial diseases caused by mutations in mitochondrial or nuclear DNA. The consortium collaborates with the United Mitochondrial Disease Foundation and maintains a Clinical Registry and Biorepository. Eligible applicants include nonprofits, universities, state and local governments, and for-profit organizations.