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Find similar grantsThis program encourages proposals focused on using or modifying living organisms, systems, or biological processes to develop new technologies to produce biochemicals and medical and agricultural products.
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Or search similar grants →According to the current listing, eligibility includes: Small businesses (fewer than 500 employees) located in the United States, with at least 50% equity owned by U. S. citizens or permanent residents. Confirm the full requirements in the official notice before applying.
Biological Technologies is funded by National Science Foundation (NSF) SBIR/STTR. Verify program details on the funder's official page before applying.
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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (NCI) is sponsored by National Cancer Institute (NCI) - NIH. The NCI SBIR and STTR programs support small businesses in developing innovative cancer technologies with strong potential to improve health outcomes. This includes therapeutics, diagnostics, imaging technologies, and tools for cancer biology research.
Biological Technologies is sponsored by Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO). Supports revolutionary research leveraging biological properties/processes to advance national security and protect warfighters; excludes incremental improvements. Key focus areas include advanced machine learning and AI for biological data and systems, combat casualty care, human performance optimization, bio-inspired materials, sensors, manufacturing, agricultural, ecological, and environmental security, biosafety, biosecurity, next-generation surveillance, and biomedical and biodefense technologies. Foreign companies may be eligible as DARPA aims for international collaboration for national security.
Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) Broad Agency Announcement (BAA) (HR001126S0003) is sponsored by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). This BAA seeks high-impact, revolutionary research ideas in biological technologies that are not currently addressed by existing programs or solicitations. It supports fundamental and applied research, including new tools, platforms, and capabilities in biotechnology with potential national security impact. Interests include AI and ML for biology, combat casualty care, and advanced biomanufacturing.
NSF's restarted SBIR/STTR program carries two transition rules almost nobody has calendared. Project Pitch invitations issued on or after July 3, 2025 must be converted to a full proposal by November 4, 2026. Phase I awardees whose awards started on or after November 6, 2023 must submit Phase II by the same date. Both cohorts were created by the program lapse, and both cliffs are hard.
Read articleNSF's rebuilt SBIR/STTR program (NSF 26-510) pairs a $305,000 Phase I with a brand-new Strategic Breakthrough award worth up to $30 million for the strongest Phase II companies. The next Project Pitch deadline is July 27, 2026. Here is how the non-dilutive funding ladder now works, why the Project Pitch gate decides everything, and how a founder should sequence the next twelve months.
Read articleAfter a disruptive pause, NSF has reopened its SBIR/STTR programs with $250 million for deep-tech startups — including a $40M scientific-instrumentation pilot and a new Strategic Breakthrough track that can reach $30 million. The first Project Pitch deadline is July 27, 2026. Here is how the reopened pipeline works, why the Project Pitch is the real gate, and how founders should sequence a submission before the window narrows.
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