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"Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 2 2026" is currently closed and not accepting applications.
Funds patient-centered comparative clinical effectiveness research addressing broad pragmatic studies.
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Or search similar grants →According to the current listing, eligibility includes: Universities, Nonprofits, State/local governments, Private entities. Confirm the full requirements in the official notice before applying.
The current listing shows up to $12 million. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was April 28, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 2 2026 is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Past winners and funding trends for this program
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
PCORI launched five simultaneous research funding tracks with $120 million in direct costs for pragmatic studies. Why this non-NIH funder deserves a place in your grant strategy.
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