Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D and E Centers) (P30 Clinical Trial Optional)

Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D and E Centers) (P30 Clinical Trial Optional) is sponsored by NIH - National Institute on Aging. Supports research centers focusing on aging demographics and economics, including Alzheimer's and related dementias.

Expired RFA-AG-25-007: Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D&E Centers) (P30 Clinical Trial Optional) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Funding Opportunity Title Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D&E Centers) (P30 Clinical Trial Optional) October 16, 2024 - Notice of Change to Key Dates for RFA-AG-25-007 and RFA-AG-25-008, Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (D&E Centers) and D&E Coordinating Center.

See Notice NOT-AG-24-071 . April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 .

August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy.

See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Notice of Funding Opportunity Resource-Related Research Project (Cooperative Agreements) See Section III. 3.

Additional Information on Eligibility .

Assistance Listing Number(s) Notice of Funding Opportunity Purpose The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications to develop or renew a Research and Development Center (P30) to advance aging research in demography, economics, and related interdisciplinary population-based social science areas, including those with a focus on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD).

This NOFO will use a phased approach which provides 2 years of support for initial development activities and 4 years of support for expanded activities. The objectives of the Demography and Economics of Aging (D&E Centers) (P30) Program are to: 1) Seed new and innovative lines of aging research in demography, economics, and related interdisciplinary population-based social science areas.

2) Integrate approaches that address the disproportionate distribution of health within and/or across populations, including with respect to those defined as Health Disparity Priority Populations in the NIA Health Disparities Research Framework . 3) Incorporate strategies that will identify and engage scholars across disciplines, career stages, and institutions.

D&E Centers shall support the infrastructure and pilot data necessary for research and program development in Center-identified population-based social science aging research themes by investigators within an institution and/or across domestic institutions.

Open Date (Earliest Submission Date) New Date December 10, 2024 per NOT-AG-24-071 (Prior Date October 01, Letter of Intent Due Date(s) New Date December 10, 2024 per NOT-AG-24-071 (Prior Date October 01, Dates in bold and italics reflect changes per NOT-AG-24-071 . Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. No late applications will be accepted for this Notice of Funding Opportunity (NOFO).

New Date January 11, 2025 per NOT-AG-24-071 (Prior Date November 02, Required Application Instructions It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description The Centers on the Demography and Economics of Aging (D&E Centers) (P30) Program was initiated in 1994.

The program has supported high-impact and innovative social science on aging, created shared resources that benefit the broader scientific community, facilitated the career enhancement of early-career and new investigators to aging research, and enabled investigators to act on emerging and urgent scientific opportunities quickly and effectively through Center research infrastructure.

The program reflects the recognition that the collaboration between and among demography, economics, and related fields are integral to advancing population science.

Since its inception, the program has worked towards the objective of cultivating the fields of demography and economics of aging via a range of activities, including supporting pilot projects, establishing research networks, holding conferences and workshops on scientific areas of focus, developing and promoting research resources and infrastructure, and sharing results and resources with scientific and policy communities as well as the public.

In the current cycle of the D&E Centers Programs which began in 2020, almost 200 pilot grants have been funded, 22 networks and 10 external research resources have been established, and other types of activities have occurred such as providing reports and resources to the research community, holding seminars, conferences, and workshops, and bringing new investigators to aging studies.

​ As part of the current cycle, the program was expanded to include D&E Centers on AD/ADRD. These centers expand upon the overall program objectives by addressing areas of demography, economics, and health services research relevant to AD/ADRD. The current cycle of the program also added a separate R24 coordinating center.

In all, the D&E Centers Programs includes 15 P30s (3 focused on AD/ADRD) and one coordinating center R24. Information on the 15 currently active D&E Centers is available here . The goal of the Centers on the Demography and Economics of Aging (D&E Centers) (P30) Program is to seed new and innovative lines of aging research in demography, economics, and related interdisciplinary population-based social science fields.

Related interdisciplinary population-based social science research fields include (but are not limited to): health services research, epidemiology, sociology, geography, public health, and public policy. Centers may focus on population-based social science aging research themes within the demography and economics of aging relevant to AD/ADRD.

Centers must integrate approaches that address the disproportionate distribution of health within and/or across populations, including those defined as Health Disparity Priority Populations in the NIA Health Disparities Research Framework. Applications should incorporate strategies that will identify and engage scholars across disciplines, career stages, and institutions.

Centers should propose population-based social science aging research theme(s) that capitalize on existing investigator expertise and resources of applicant institution(s) and clearly describe plans to enhance these areas via three required Cores: Core A. Administrative and Research Support Core Core B. Program Development (Pilot) Core Core C.

Communication and Dissemination Core Centers may choose from up to three optional cores: Core D. External Network Core Core E. External Research Resources Support Core Core F.

Remote Data Enclave Core) Specific Center activities include: Pilot project support and mentoring Communication and dissemination of Center activities and achievements to diverse audiences The sharing of Center-produced data and related resources to the fullest extent possible The development of innovative national and international research networks of researchers Activities that expand the number of researchers and institutions with the capacity to apply for NIA funding The development and enhanced sharing of relevant databases The rapid application of research results from these databases The development of remote data enclaves and data sharing methods for the analysis of large-scale, often-longitudinal, databases with linked administrative, electronic health record, biological, and/or genetic information Centers are expected to work with the Coordinating Center for the Centers on the Demography and Economics of Aging, including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D&E CC) (U24) on collaborative research activities (including the Emerging Scholar Pilot Projects and Mentoring Program) across Centers; dissemination of Center advances, activities, and resources to relevant audiences; and tracking and reporting of Center activities.

NIA is particularly interested in supporting D&E Center applications that propose population-based social science aging and/or AD/ADRD research theme(s) that address one or more of the priority topic areas identified in the National Advisory Council on Aging's 2019 BSR Review Committee Report , including the application of population-level approaches to: a) improve understanding of health disparities in aging including modifiable mechanisms, b) study influences of macro-social trends on aging, c) enhance research on cognitive aging, and d) support research to improve care for persons with dementia and caregivers.

Examples of priority topic areas for population-based social science aging research themes include (but are not limited) to: Determinants of population trends at older ages in physical and cognitive functioning, disability, morbidity, mortality, health, and well-being. Life course pathways by which social, behavioral, environmental, and structural risk and protective factors lead to disparities in health outcomes.

Mechanisms through which socioeconomic status, race/ethnicity, and other factors operate as risk factors for poor health and health disparities at older ages. Interrelationships between work, family and health, and the consequences of work trajectories for health outcomes at older ages.

How environmental, social, economic, institutional, structural, and other factors affect health and well-being, including health-related behaviors, healthcare utilization, health disparities, and responses to public health interventions. Influence on the aging process and aging outcomes of different social, economic, familial, environmental, geographic, cultural, and institutional contexts.

Consequences of U.S. and global population aging/demographic change for the care and well-being of older people with disease and disability. Integration of genetic approaches and data on biological risk into social science population research on aging. Effects of population-level interventions on health, health delivery, quality of care, and disparities.

Impact of health care services, the health care system, and long-term supports and services, including organizational influences on the health and well-being of older persons with chronic disease and disability, and impacts on their care partners. Impacts of extreme weather, natural disasters, pollution, and other environmental exposures on health across the life course.

Effects of migration and integration on immigrant older adult health and well-being. Aging in global contexts. Impacts of racism, sexism, etc. on population health and inequities.

Demographic and/or economic causes and consequences of the COVID-19 pandemic.

In addition to the National Advisory Council on Aging's 2019 BSR Review Committee Report recommendations listed above, illustrative topics for AD/ADRD D&E Centers include (but are not limited to) those that examine the topics listed directly above in the context of the risk, development, progression, diagnosis, and clinical presentation of AD/ADRD, AD/ADRD health care (access, utilization, and quality), and aspects of caregiving experiences for care partners and persons living with dementia (PLWD).

Applications may integrate population-level biodemographic, social, economic, and/or healthcare system factors. In addition, applications may focus on AD+ADRD Research Implementation Milestones including (but not limited to) the following: AD+ADRD Milestone 1. P.

Population Studies: Exposome studies and health disparities AD+ADRD Milestone 1. R. Population Studies: Pollution and climate change AD+ADRD Milestone 1.

S. Health Equity: Understand and reduce barriers to health equity AD+ADRD Milestone 13. D.

Care & Caregiving: Secondary data analysis AD+ADRD Milestone 13. J. Care & Caregiving: Dementia care workforce AD+ADRD Milestone 13.

N. Care & Caregiving: Health care access, use, quality disparities AD+ADRD Milestone 13. P.

Care & Caregiving: Policy and payment models AD+ADRD Milestone 14. P. Partnerships: Global data sharing All applications must integrate approaches that address the disproportionate distribution of health within and across populations, including with respect to those defined as Health Disparity Priority Populations in the NIA Health Disparities Research Framework .

Applications must clearly identify the Center’s population-based social science aging research themes and relevant Health Disparity Priority Population(s) in the application, including in the Overall Specific Aims, as well as whether the application is focused primarily on AD/ADRD-related science or on general aging topics.

Tracking Criteria and Reporting The continued success and sustainability of the D&E Centers Programs requires that the Centers complete their proposed Core activities.

Throughout the project period, NIA expects that a Center will be able to demonstrate how its Core activities advance the following Center Program objectives: 1) Seed new and innovative lines of research in the demography and economics of aging and related interdisciplinary population-based social science areas.

2) Integrate approaches that address the disproportionate distribution of health within and/or across populations, including with respect to those defined as Health Disparity Priority Populations in the NIA Health Disparities Research Framework . 3) Incorporate strategies that will identify and engage scholars across disciplines, career stages, and institutions.

Centers are responsible for tracking and monitoring progress and success through Core tracking criteria described in Section IV via semi-annual reporting to the D&E CC to be funded through RFA-AG-25-008 and the annual non-competing continuation (Type 5).

Based on tracking criteria and other considerations, staff in the Office of Planning, Analysis, and Evaluation at NIA may evaluate the overall D&E Centers Program and may provide recommendations for continuation and/or modification of the D&E Centers Program. Timeline of the Phased Award This NOFO uses a phased award approach. Proposed projects must include an overall timeline of both phases of the award.

The timeline should incorporate the milestones for Phase 1 (2 years) as outlined below as well as the major goals of the entire project. Milestones: This funding opportunity include milestones that must be met at the end of Year 2. Funding of Phase 1 does not guarantee support of Phase 2.

If milestones are not achieved, as determined by the NIA Program Official assessment of recipient progress, NIA can choose to terminate the award, provide a mid-project extension (without additional funds), or modify aspects or conditions of the D&E Center at NIA’s discretion. Milestones will be included in the Terms and Conditions of the grant, if awarded.

As with any award, continuation, even during the period recommended for support, is conditional upon satisfactory progress. By the end of Phase 1/Year 2, D&E Centers are expected to accomplish the following milestones: Successful establishment of a public-facing website. The website should minimally include an overview of the D&E Center and promote activities and achievements (publications, pilot project calls, pilot project findings).

Successful establishment of an Emerging Scholars Pilot Projects and accompanying Mentorship Program and recruitment and support (made awards) of the first cohort of scholars and mentors, including the initiation of at least 2 mentorship activities (i.e. at least 2 presentations/seminars according to the application’s plan).

Successful establishment of the Advisory Board and the successful organization of at least one meeting of the Advisory Board, PI team, and NIA staff. Successful reporting (semi-annually) of tracking criteria to the Coordinating Center. Prior to the end of the first phase, awardees will submit a package that requests transition to the second phase of support.

This package will include a progress report that describes progress towards each of the initial milestones and a clear description of how research during the Phase 2 will be impacted by attainment of those milestones. These materials will be reviewed by NIA program staff and then, if approved, the grant will transition to Phase 2 of support without the need to submit a new grant application.

Decisions on transitioning to Phase 2 will be based on the successful completion of the originally described milestones, program priorities, and availability of funds. Non-responsiveness Criteria The following types of applications will be considered non-responsive and will be withdrawn prior to review: Applications that do not include the three required Cores (Core A. Administrative and Research Support Core, Core B.

Program Development (Pilot) Core, and Core C. Communication and Dissemination Core). Applications that do not devote at least half of Core B.

Program Development (Pilot) Core funds to the Emerging Scholars Pilot Projects and an accompanying Mentorship Program. Applications that do not identify the Center’s population-based social science aging research theme(s) in the Overall section’s Specific Aims.

Applications that do not identify the Center’s focus on the disproportionate distribution of health within and/or across populations, including with respect to those defined as Health Disparity Priority Populations in the NIA Health Disparities Research Framework in the Overall section’s Specific Aims.

Applications that do not clearly articulate relevance of the project for AD/ADRD in the identified Center themes, including in the Overall Specific Aims, will not be considered for AD/ADRD set-aside funds.

NIA shares reports outlining Institute priorities, including: National Advisory Council on Aging’s 2019 BSR Review Committee Report AD and ADRD Research Implementation Milestones NIA Health Disparities Framework NASEM’s Decadal Survey of Behavioral and Social Science Research on AD/ADRD Notice of NIH’s Interest in Diversity NIA provides a variety of research resources to facilitate population-based behavioral and social research including: NIA-supported Behavioral and Social Research Centers NIA-supported Behavioral and Social Research Networks NIA Global Aging Behavioral & Social Research Overview Responses to frequently asked questions about this NOFO will be posted here .

Clinical Research Operations Management System NIA uses a central resource to NIA staff and extramural investigators to facilitate/support the conduct and management of clinical research.

NIA Clinical Research Operations & Management System (CROMS) is a comprehensive data management system to support the business functions, management, and oversight responsibilities of NIA grants that support the conduct of clinical research with human subjects.

NIA investigators of grants, contracts, and cooperative agreements that are active as of July 1, 2021, including clinical trials funded as pilots, exploratory studies, or other projects through this Consortium, and support human subjects research as defined by the DHS HHS OHRP regulations at 45 CFR 46 will be required to interact with and use existing and future components of CROMS as required by NIA throughout the lifecycle of the grant, as described in NOT-AG-23-017 .

Data to be submitted to NIA CROMS includes those elements reported in the standard NIH requirement annual progress report (GPS 4. 1. 15.

7). Details regarding the standard operating procedures for CROMS can be found on the NIA CROMS website . When applicable, all NIA grantees must ensure: 1.

The study’s Informed Consent Document (ICD) lists “The National Institutes of Health (NIH) and its authorized representatives” as one of the organizations that may look at or receive copies of information in participants’ study records. According to DHS HHS OHRP 45 CFR 46 §46. 116 , all ICDs must contain “A statement describing the extent, if any, to which confidentiality of records identifying the participant will be maintained.

” If using the NIA informed consent template , please see Section 6: Statement of Confidentiality. 2. An assigned NIH ClinicalTrials.

gov identifier (NCT number) is reported in its respective CROMS study record within three months after assignment, and the reporting of final enrollment data to CROMS is consistent with final enrollment data reported in ClinicalTrials. gov. See Section VIII. Other Information for award authorities and regulations.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards NIA intends to commit approximately $9,000,000 in FY 2025 to fund 9 to 12 general aging awards. NIA intends to commit approximately $2,250,000 in FY 2025 to fund 2 to 4 AD/ADRD awards.

NIA expects to fund Centers of different sizes. Applications are limited to $600,000 in first-year direct costs. The maximum project period is 6 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISIs) Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations A D&E Center (P30) grant requires substantial pre-existing research activity on population aging at the applicant institution.

A minimum of at least two peer-reviewed, externally funded, and currently active research projects are required that are directly relevant to aging and that are rooted in population-based social science research in demography or economics or related fields. Ideally, applicant institutions will have a substantial base of such externally funded research relevant to the Center’s population-based social science research theme(s).

Sub-projects of NIA P01 grants may be counted as individual projects. In the case of multi-institution applications, at least one institution should meet this criterion.

Institutions with complementary expertise (e.g., current active externally-funded population-based social science aging research; expertise in aging research on NIA Health Disparities Priority Populations; experience and ability to identify and engage scholars across disciplines, career stages, and institutions) are encouraged to partner together to develop applications that achieve the D&E Centers Program goals.

Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed.

Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3. 9.

2 Electronically Submitted Applications for additional information. System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from diverse backgrounds, including individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019 .

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2- Definitions of Terms.

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed in this notice of funding opportunity to do otherwise and where instructions in the How to Apply - Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: National Institute on Aging (NIA) All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Component Type for Submission Core A - Administrative and Research Support Core Core B - Program Development Pilot Core Core C - Communication and Dissemination Core Core D - External Innovative Network Core Core E - External Research Resources Support Core Core F - Remote Data Enclave Core Instructions for the Submission of Multi-Component Applications The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application.

When preparing the application, use Component Type ‘Overall’. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted. SF424(R&R) Cover (Overall) PHS 398 Cover Page Supplement (Overall) Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in Overall component.

Research & Related Other Project Information (Overall) Follow standard instructions. Timeline : (2 page limit) All applications must include a project timeline labeled “Timeline” under Other Attachments.

The Timeline must contain separate sections for Phase 1 and 2 of the proposed project, outlining the major goals of the project plan, as well as a sub-section devoted to describing milestones to be achieved during Phase 1, to qualify for the transition to Phase 2.

Project/Performance Site Locations (Overall) A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application. In the Project Director/Principal Investigator section of the form, use Project Role of ‘Other’ with Category of ‘Project Lead’ and provide a valid eRA Commons ID in the Credential field.

In the additional Senior/Key Profiles section, list Senior/Key persons that are working in the component. If more than 100 Senior/Key persons are included in a component, the Additional Senior Key Person attachments should be used.

Key personnel should be leaders in aging and demography, economics, and related interdisciplinary population-based social science areas, including those with a focus on AD/ADRD; Health Disparity Priority Populations in the NIA Health Disparities Research Framework; D&E Center themes; and/or identifying, developing, training, and mentoring scholars, including in the development of successful R-series/K-series awards.

A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon