Development of Courses or Workshops in Metabolomics (R25)

Development of Courses or Workshops in Metabolomics (R25) is sponsored by NIH Common Fund. Supports the development of educational programs to train researchers and clinicians in metabolomics methodologies and applications.

Expired RFA-RM-11-018: Development of Courses or Workshops in Metabolomics (R25) This notice has expired. Check the NIH Guide for active opportunities and notices. of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) of Participating Organizations This Funding Opportunity Announcement (FOA) is developed as a Common Fund initiative ( http://commonfund. nih. gov/ ) through the NIH Office of the NIH Director, Office of Strategic Coordination ( http://dpcpsi.

nih. gov/osc/ ). The FOA will be administered by the National Institute of General Medical Sciences (NIGMS/NIH), ( http://www.

nigms. nih. gov ) Funding Opportunity Title Development of Courses or Workshops in Funding Opportunity Announcement (FOA) Number Additional Information on Eligibility .

Catalog of Federal Domestic Assistance (CFDA) Number(s) Metabolomics represents a rapidly growing field that has the potential to advance our understanding of human diseases and patient responses to therapeutic procedures. This R25 grant program supports the development of innovative courses or workshops to educate students and investigators who wish to receive training in the field of metabolomics.

The ultimate goal of these programs is to prepare investigators to advance the use of metabolomics in translational research and to support highly interdisciplinary teams that are conducting metabolomic studies.

This award is intended to a) support planning and implementation of new workshops or courses in the varied disciplines needed for metabolomics or b) support the expansion of existing workshops or educational courses in metabolomics. Open Date (Earliest Submission Date) Letter of Intent Due Date 31, 2012 , by 5:00 PM local time of applicant organization.

AIDS Application Due Date(s) Required Application Instructions It is critical that applicants follow the instructions in 424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of the Announcement Section I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Full Text of Announcement Section I. Funding Opportunity Description This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact.

All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress Despite the early promise of metabolomics, challenges remain in the application of this approach to biomedical research.

The National Institutes of Health (NIH) Common Fund has developed a comprehensive program to advance the potential of metabolomics in understanding human health and combating disease ( http://commonfund. nih. gov/Metabolomics/ ).

The Common Fund Metabolomics Program includes a number of Funding Opportunity Announcements with the collective goal of Increasing Metabolomics Research Capacity. This FOA contributes to that goal by encouraging applications that propose creative and innovative educational courses or workshops in the field of metabolomics.

Researchers from a variety of research communities have become interested in metabolomics and this FOA is to encourage the development of courses and workshops to instruct interested investigators in the analytical procedures, experimental methodologies, and the informatic and computational tools that are necessary for this field to be effective in advancing biomedical and biohavioral research.

Metabolomics is the study of low molecular weight molecules or metabolites found within cells and biological systems and the metabolome is a measure of the functional output of biological pathways. Metabolites are conserved across various animal species, facilitating the extrapolation of research findings in laboratory animals to humans and thus clinical and translational research.

Common technologies for measuring the metabolome include mass spectrometry (MS) and nuclear magnetic spectroscopy (NMR), which can measure hundreds to thousands of unique entities (UCE).

The purpose of this FOA is to create an infrastructure that supports education in metabolomics research and dissemination of this topic to increase the number of well-trained investigators with the interdisciplinary skills required to perform these studies including analytical methodologies, data interpretation and study design that can address translational questions.

The NIH Research Education (R25) grant mechanism is designed to support the development of creative and innovative research education programs in metabolomics.

Courses or workshops may include, but are not limited to analytical techniques for metabolite identification, use of mass spectrometry and NMR in metabolomic research, bioinformatics and computational instruction including chemometrics, pathway or network analysis, multivariate data analysis, and database building and how to apply metabolomics to biomedical research projects including lab management procedures for sample collection, processing and storage.

PD(s)/PI(s) may propose holding multiple workshops or courses a year with some meetings covering more advanced or specialized topics to meet the needs of the metabolomics community The PD(s)/PI(s) is required to describe the workshop or course, explain how this workshop or course is distinguished from other existing courses from the applicant/participating institution(s); and describe the immediate and long term objectives of the award and how those objectives will meet the needs of the metabolomics community.

These educational programs can be directed at undergraduate or graduate students, postdoctoral and clinical fellows, and experienced investigators or combinations of these groups. The ultimate goal of these programs is to prepare investigators to advance the use of metabolomics in translational research and to direct highly interdisciplinary teams or collaborations in metabolomic studies.

The National Institutes of Health (NIH) has a longstanding commitment to fostering a diverse and highly capable biomedical and behavioral research workforce that helps achieve the NIH This award is intended to a) support planning and implementation of new workshops or courses or b) support the expansion of existing workshops or educational courses in metabolomics.

To achieve the breadth and diversity of courses or workshops needed to meet these goals, applicants must include multiple departments and may include multiple centers, schools or institutions. As part of this program, awardees will be expected to implement the courses or workshops that are developed in year 1 of the award in their institution(s) or at regional or national meetings in years 2 to 5 of the award.

It is expected that such courses or workshops will be models that could be transferable to other educational or research training settings in whole or in part.

The proposed educational program may complement ongoing research training and education occurring at the applicant institution, but the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support. The R25 grant program is not a substitute for an institutional research training program (T32) and cannot be used to circumvent or supplement Ruth L.

Kirschstein National Service Award (NRSA) mechanisms.

The budgets for applications to this FOA may include support for, but are not limited to, the following items: Purchase of necessary instructional aids Support for technical staff to oversee and Support for guest lecturers from academia and Support for web based programs that will be used Advertising to attract the best possible candidates to attend the workshops Participant costs for those individuals who will benefit from the proposed research education program PD(s)/PI(s) may seek additional funding from other sources to augment NIH funding to provide demonstrations and/or hands-on training with appropriate equipment and computational tools.

Descriptions of these other funding sources are not required at the time of submission, but the PD(s)/PI(s) should indicate if their training plans will include demonstrations or hands-on training to provide reviewers with sufficient information to properly evaluate Integral to the success of the Common Fund Metabolomics Programs is communication and interaction among the participants of the various complementary activities.

In order to facilatate this interaction, an annual Program retreat will be convened. PD(s)/PI(s) of grants funded by this FOA will be expected to attend and incorporate these meeting costs in their annual Section II.

Award Information Application Types Allowed Glossary and the SF 424 (R&R) Application Guide provide details on Funds Available and Anticipated Number of Awards The total amount of funds available for these awards is approximately $1,500,000 for FY2012-2016, contingent upon receiving scientifically meritoriousapplications.

Two to three awards are anticipated Applicants may request up to a total of $50,000 in direct costs for the first year planning of curricula for the workshop or course. Applicants may request up to a total of $100,000 annually in direct costs for years 2 to 5 to implement courses and workshops. Budgets need to reflect actual needs of the proposed project.

The total project period may not exceed 5 years. Individuals designing, directing, and implementing the research education program may request salary and fringe benefits appropriate for the person months devoted to the program. Salaries requested may not exceed the levels commensurate with the institution's policy for similar positions and may not exceed the congressionally mandated cap.

(If mentoring interactions and other activities with students/participants are considered a regular part of an individual's academic duties, then any costs associated with the mentoring and other interactions with students/participants are not allowable costs from grant funds). Participant costs for those individuals who will benefit from the proposed research education program may be covered from the grant award.

Participants may receive funds to defray partial tuition or fees for course credit and other education-related expenses and these charges may be treated as an allowable grant expense. Other tuition and fees that are not associated with participation in the workshops or courses may not be charged to the grant. Participant costs may include funds to cover travel and per diem expenses.

It is expected that preference will be given to undergraduate and predoctoral students, postdoctoral and clinical fellows, and experienced investigators who indicate a financial need to attend this educational program. . Participant costs must be itemized in the proposed budget Expenses for foreign travel must be exceptionally well justified.

Individuals supported by NIH training and career development mechanisms (K, T, or F awards) may receive, and indeed are encouraged to receive, educational experiences supported by the R25 mechanism, as participants, but may not receive salary or stipend supplementation from a research education program.

Because the R25 mechanism is not intended as a substitute for an NRSA institutional training program (T32), costs to support full-time participants (supported for 40 hours/week for a continuous, 12-month period) are not Other Program-Related Expenses Consultant costs, equipment, supplies, travel for key persons, and other program-related expenses may be included in the proposed budget.

These expenses must be justified as specifically required by the proposed program and must not duplicate items generally available at the applicant institution. Costs associated with the organization of courses, workshops, etc., that will not be offset by registration fees may be budgeted.

All requests for these other program related expenses support must Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees and expenditures for equipment), rather than on the basis of a negotiated rate agreement. described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Eligible Agencies of the Federal Government U.S. Territory or Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.

All registrations must be completed by the application due date. The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program.

Institutions with existing Ruth L. Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other Federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving NIH support.

In many cases, it is anticipated that the proposed research education program will complement ongoing research training occurring at the applicant institution. Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations must complete the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following Contractor Registration (CCR) must maintain an active registration, to be renewed at least annually All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.

All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least 4-6 weeks prior to the application due date.

Eligible Individuals (Program Director(s)/Principal Investigator(s)) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from diverse backgrounds, including underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PD(s)/PI(s), visit the Multiple Program Director(s)/Principal Investigator(s) Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) The PD(s)/PI(s) should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program.

The PD(s)/PI(s) will be expected to monitor and assess the program and submit all documents and reports as required. This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed.

Researchers from diverse backgrounds, including racial and ethnic minorities, persons with disabilities, and women are encouraged to participate. Faculty should have research expertise and experience relevant to Applications must describe the intended participants, and the eligibility and/or specific educational background characteristics that are essential for participation in the proposed research education program.

Identify the career levels essential for participation in the planned program. Because this is an educational and not a training mechanism, non-U.S. citizens may participate in this program. and Submission Information Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.

gov . 2. Content and Form of Application Submission It is critical that applicants follow the instructions in (R&R) Application Guide , except where instructed in this funding opportunity announcement to do otherwise.

Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed research Name, address, and telephone number of the PD(s)/PI(s) Names of other key personnel Participating institutions Number and title of this funding opportunity The letter of intent should be sent to: 45 Center Drive, MSC 6200 Required and Optional Components The forms package associated with this FOA includes all applicable components, mandatory and optional.

Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow the instructions in the SF 424 (R&R) Application Guide to ensure you complete all appropriate optional All page limitations described in the SF424 (R&R) Application Guide and the Table of Page Limits must be followed.

SF424 (R&R) Other Project Information Component Follow all instructions provided in the SF424 (R&R) Application Guide with the following modifications: Describe the educational environment, including the facilities, laboratories, participating departments, computer services, and any other resources to be used in the development and implementation of the proposed program.

List all thematically related sources of support for research training and education following the format for Current and Pending Support. Follow all instructions provided in the SF424 (R&R) Application Guide with the following modifications: Include all personnel other than the PD(s)/PI(s) in the Other Personnel section, including clerical and administrative staff.

Use the section on Participant/Trainee Support Costs to include all allowable categories of funds requested to support participants in the PHS 398 Research Plan Component All instructions in the SF424 (R&R) Application Guide must be followed, with the additional instructions described below: The Research Strategy section must be used to upload Program Plan , which must include the following components described below: Proposed Research Education Program, Institutional Environment and Commitment, Program Director(s)/Principal Investigator(s), Program Faculty/Staff, Program Participants, Diversity Recruitment and Retention Plan, Plan for Instruction in the Responsible Conduct of Research, Evaluation Plan,.

Research Education Program (Component of Research Education Program Plan) While the proposed research education program may complement ongoing research training and education occurring at the applicant institution, the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support.

When research training programs are on-going in the same department, the applicant organization should clearly describe the distinction between the intended participants in the proposed research education program and the research training supported by the training program. The information should include a description of the education and/or career levels of the planned participants.

Environment and Commitment (Component of Research Education Program Plan) Describe the institutional environment, reiterating the availability of facilities and educational resources (described separately under Facilities & Other Resources ), that can contribute to the planned Research Education Program. Evidence of institutional commitment to the research educational program is required.

A letter of institutional commitment must be attached as part of Letters of Support. Appropriate institutional commitment should include the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education program.

Program Director(s)/Principal Investigator(s) (Component of Research Education Program Plan) Describe arrangements for administration of the program, provide evidence that the Program Director(s)/Principal Investigator(s) is actively engaged in research and/or teaching in an area related to the mission of NIH, and can organize, administer, monitor, and evaluate the research education program, as well as evidence of institutional and community commitment and support for the proposed program.

Program Faculty/Staff (Component of Research Education Program Plan) Describe the characteristics and responsibilities of the participating faculty; provide evidence that the participating faculty and preceptors are actively engaged in research or other scholarly activities related to the mission of NIH.

Participants (Component of Research Education Program Plan) Where the proposed program involves participants, provide details about the pool of expected participants, their qualifications, recruitment strategies and sources of applicant pool, etc. It is expected that the participants will come from a variety of institutions outside the and Retention Plan (Component of Research Education Program Plan) The NIH recognizes a unique and compelling need to promote diversity in the biomedical, behavioral, clinical and social sciences research workforce.

The NIH expects efforts to diversify the workforce to lead to the recruitment of the most talented researchers from all groups; to improve the quality of the educational and training environment; to balance and broaden the perspective in setting research priorities; to improve the ability to recruit subjects from diverse backgrounds into clinical research protocols; and to improve the Nation's capacity to address and eliminate health disparities.

Accordingly, the NIH continues to encourage institutions to diversify their student and faculty populations and thus to increase the participation of individuals currently underrepresented in the biomedical, clinical, behavioral, and social sciences such as: individuals from underrepresented racial and ethnic groups; individuals with disabilities; and individuals from socially, culturally, economically, or educationally disadvantaged backgrounds that have inhibited their ability to pursue a career in health-related research.

Institutions are encouraged to identify candidates who will increase diversity on a national or institutional basis. The NIH is particularly interested in encouraging the recruitment and retention of the following classes of participants: racial and ethnic groups that have been shown by the National Science Foundation to be underrepresented in health-related sciences on a national basis (see data at http://www. nsf.

gov/statistics/showpub. cfm? TopID=2&SubID=27 and the most recent report on Women, Minorities, and Persons with Disabilities in Science and Engineering ).

The following racial and ethnic groups have been shown to be underrepresented in biomedical research: African Americans, Hispanic Americans, Native Americans, Alaska Natives, Hawaiian Natives, and natives of the U.S. Pacific Islands.

In addition, it is recognized that underrepresentation can vary from setting to setting; individuals from racial or ethnic groups that can be convincingly demonstrated to be underrepresented by the grantee institution should be encouraged to participate in this program. disabilities, who are defined as those with a physical or mental impairment that substantially limits one or more major life activities.

disadvantaged backgrounds who are defined as: come from a family with an annual income below established low-income thresholds. These thresholds are based on family size; published by the U.S. Bureau of the Census; adjusted annually for changes in the Consumer Price Index; and adjusted by the Secretary for use in all health professions programs.

The Secretary periodically publishes these income levels at HHS - Poverty Guidelines, Research, and Measurement .

For individuals from low income backgrounds, the institution must be able to demonstrate that such participants have qualified for Federal disadvantaged assistance or they have received any of the following student loans: Health Professions Student Loans (HPSL), Loans for Disadvantaged Student Program, or they have received scholarships from the U.S. Department of Health and Human Services under the Scholarship for Individuals with Exceptional Financial Need.

come from a social, cultural, or educational environment such as that found in certain rural or inner-city environments that have demonstrably and recently directly inhibited the individual from obtaining the knowledge, skills, and abilities necessary to develop and participate in a research career.

Recruitment and retention plans related to a disadvantaged background (C1 and C2) are most applicable to high school and perhaps to undergraduate candidates, but would be more difficult to justify for individuals beyond that level of academic achievement. Under extraordinary circumstances the PHS may, at its discretion, consider an individual beyond the undergraduate level to be from a disadvantaged background.

Such decisions will be made on a case-by-case basis, based on appropriate New applications must include a description of plans to enhance recruitment of a diverse participant pool, including speakers, and may wish to include data in support of past accomplishments. Applications without a diversity recruitment and retention plan will be considered incomplete and will not be reviewed.

Instruction in the Responsible Conduct of Research (Component of Research Every participant supported by this Research Education grant must receive instruction in the responsible conduct of research. All applications must include a plan to provide such instruction. The plan must address five components (format; subject matter; faculty participation; duration of instruction; and frequency of instruction) as detailed in NOT-OD-10-019 .

Renewal (Type 2) applications must, in addition, describe changes in formal instruction over the past project period and plans for the future that address any weaknesses in the current instruction plan. All participating faculty who served as course directors, speakers, lecturers, and/or discussion leaders during the past project period must be named in the application.

Applications lacking a plan for instruction in responsible conduct of research may be delayed or not accepted for review. The background, rationale and more detail about instruction in the responsible conduct of research can be found in NOT-OD-10-019 . If such instruction is not appropriate for the proposed research education program, then the PD(s)/PI(s) must provide a strong justification for its exclusion.

Evaluation Plan (Component of Research Education Program Plan) Applications must include a plan for evaluating the activities supported by the award. The application must specify baseline metrics (e.g., numbers, educational levels, and demographic characteristics of participants), as well as measures to gauge the short or long-term success of the research education award in achieving its objectives.

Wherever appropriate, applicants are encouraged to obtain feedback from participants to help identify weaknesses and to provide suggestions for improvements.

are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies; GWAS) as provided in the SF424 (R&R) Application Guide, with the Applications are expected to include a software dissemination plan if support for development, maintenance, or enhancement of software is requested in the application.

There is no prescribed single license for software produced. However, the software dissemination plan should address, as appropriate, the following goals: Software source code should be freely available to biomedical researchers and educators in the non-profit sector, such as institutions of education, research institutions, and government laboratories.

Users should be permitted to modify the code and share their modifications with others. The terms of software availability should permit the commercialization of enhanced or customized versions of the software, or incorporation of the software or pieces of it into other software packages.

To preserve utility to the community, the software should be transferable such that another individual or team can continue development in the event that the original investigators are unwilling or unable to do so. Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Part I.

Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission. Organizations must submit applications via Grants.

gov , the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants administration. responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide. 4.

Intergovernmental Review This initiative is not subject to intergovernmental All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Pre-award costs are allowable only as described in the NIH Grants Requirements and Information Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide.

Paper applications will not be accepted. Applicants must complete all required registrations before the application due date. Section III.

Eligibility Information contains information about registration. For assistance with your electronic application or for more information on the electronic submission All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package .

Failure to register in the Commons and to include a valid PD(s)/PI(s) Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons and for the Central Contractor Registration (CCR).

Additional information may be found in the SF424 (R&R) Application Guide. tips for avoiding common errors. Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review and responsiveness byNIGMS, NIH.

Applications that are incomplete and/or nonresponsive will not be Post Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115 . Section V. Application Review Information Only the review criteria described below will be considered in the review process.

As part of the NIH mission , all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the