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DOE Artificial Intelligence (AI) Program / Advanced Scientific Computing Research (ASCR) is sponsored by U.S. Department of Energy (DOE) Office of Science. This opportunity supports mission-aligned projects and measurable outcomes related to the co-design of learning systems and AI environments that significantly advance the field of AI for public benefit within DOE's Congressionally-authorized mission-space.
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Advanced Scientific Computing Research | Department of Energy Advanced Scientific Computing Research Scientific computing, including modeling, simulation and artificial intelligence, coupled with traditional theoretical and experimental approaches, enables breakthrough scientific discoveries and pushes innovation forward.
As scientific modeling and simulation become more complex and ambitious, high-performance computing (HPC), commonly known as supercomputing, provides the invaluable ability to perform these complex calculations at high speeds.
Supercomputers along with advances in software, algorithms, methods, tools and workflows equip researchers with powerful tools needed to study systems that would otherwise be impractical, or impossible, to investigate by traditional means due to their complexity or the danger they pose.
The Advanced Scientific Computing Research (ASCR) program leads the nation and the world in supercomputing, advanced networking and state-of-the-art research in computer science, mathematics and computational science. ASCR’s coordinated research efforts directed at exploiting the incredible power of HPC allow the scientists to solve the Nation’s most pressing grand challenge problems in energy, climate change and human health.
These discoveries will help shape our understanding of the universe, bolster US economic competitiveness, and contribute to a better future. Maintaining U.S. leadership in the fierce international competition requires computer scientists, applied mathematicians and computational scientists who know how to develop tools and methods to harness supercomputers to solve complex problems today and develop the technology of the future.
Supercomputers push the edge of what is possible for US science and innovation—enabling scientists and engineers to explore systems too large, too complex, too dangerous, too small, or too fleeting to do by experiments.
From atoms to astrophysics understanding these complex systems delivers new materials, new drugs, more efficient engines and turbines, better weather forecasts, and other technologies to maintain U.S. competitiveness in a wide array of industries. We support U.S. research at hundreds of institutions and deploy open-access supercomputing and network facilities at our National Laboratories.
Our supercomputers are some of the world’s most powerful, and our high-speed research network is specially built for moving enormous scientific data, at light speed. From artificial intelligence to quantum computing, our vibrant research community keeps the U.S. ahead in a rapidly evolving high-tech field and impacted industries.
Through strong partnerships with the industry and interdisciplinary collaborations between domain scientists, applied mathematicians and computer scientists, we maintain U.S. leadership in science, technology, and innovation. Learn more about the mission of Advanced Scientific Computing Research and how we support it.
U.S. scientists and collaborators have a powerful new instrument at their disposal—the Nation's first exascale supercomputer. In June, 2022, the international Top500 list of most powerful systems in the world named the Department of Energy (DOE) Office of Science system Frontier the world's fastest supercomputer.
Located at DOE's Oak Ridge National Laboratory, Frontier is a collaboration between DOE and U.S. technology companies HPE and AMD. This milestone marks the beginning of the long-awaited exascale era, following more than 10 years of research and development by the nation's brightest minds—not only for Frontier but other upcoming DOE exascale systems.
Exascale systems will provide the next-generation of computing desperately needed to understand climate change and prediction, design new materials for energy technologies and fusion reactors, build stronger and more adaptive power grid, develop new Cancer treatments, provide rapid near real-time data analysis for scientific facilities such as light sources, and address challenges in energy, environment, and national security.
The Frontier supercomputer at the Department of Energy’s Oak Ridge National Laboratory earned the top ranking on May 30, 2022, as the world’s fastest on the 59th TOP500 list, with 1. 1 exaflops of performance. Video courtesy of Oak Ridge National Laboratory Building a Flexible Control Framework for Quantum Networks A new control framework enables automated, reliable control of quantum networks, paving the way for practical deployment.
Learn More about Building a Flexible Control Framework for Quantum Networks Improving Computing Memory Performance for Scientific Discovery A new framework employs usage patterns to improve data placement.
Learn More about Improving Computing Memory Performance for Scientific Discovery Scientists Compare Throughput for Quantum vs. Conventional Networks A comparison of throughput measurements and analytical capacity estimates for quantum networks finds surprising patterns.
Learn More about Scientists Compare Throughput for Quantum vs. Conventional Networks Novel Hardware Approach Produces a New Quantum Computing Paradigm New theoretical approach to quantum computing hardware design via an algorithm avoids some of the complex difficulties in modern quantum computers.
Learn More about Novel Hardware Approach Produces a New Quantum Computing Paradigm Bringing FAIR Principles to AI Models Researchers extend findable, accessible, interoperable, and reusable principles for datasets to scientific datasets and software.
Learn More about Bringing FAIR Principles to AI Models Novel Hybrid Scheme Speeds the Way to Simulating Nuclear Reactions on Quantum Computers Classical and quantum chips combine to simulate the collision of two neutrons on a present-day quantum computer.
Learn More about Novel Hybrid Scheme Speeds the Way to Simulating Nuclear Reactions on Quantum Computers Artificial Atoms Power a Novel Quantum Processor Architecture Fluxonium qubits can build cutting-edge quantum devices that will harness the potential of quantum computing.
Learn More about Artificial Atoms Power a Novel Quantum Processor Architecture Fair Play for Data: Researchers Develop Practical FAIR Principles for Data Sets FAIR (findable, accessible, interoperable, reusable) principles facilitate the use of large data sets by human and machine researchers.
Learn More about Fair Play for Data: Researchers Develop Practical FAIR Principles for Data Sets Advanced Computing Brings Autonomous Investigations to Nanostructured Surfaces Machine learning and artificial intelligence accelerate nanomaterials investigations.
Learn More about Advanced Computing Brings Autonomous Investigations to Nanostructured Surfaces Modeling Polymers for Next-Generation Manufacturing and Sustainability New computational methods “fingerprint” polymer motions under flow.
Learn More about Modeling Polymers for Next-Generation Manufacturing and Sustainability Department of Energy Announces $6 Million for Research Toward a More Robust and Reliable Electric Grid Learn More about Department of Energy Announces $6 Million for Research Toward a More Robust and Reliable Electric Grid DOE, ORNL Announce Opportunity to Define Future of High-Performance Computing Learn More about DOE, ORNL Announce Opportunity to Define Future of High-Performance Computing Department of Energy Announces $68 Million in Funding for Artificial Intelligence for Scientific Research Learn More about Department of Energy Announces $68 Million in Funding for Artificial Intelligence for Scientific Research Department of Energy Announces $30 Million for Research to Accelerate Scientific Advances at User Facilities Learn More about Department of Energy Announces $30 Million for Research to Accelerate Scientific Advances at User Facilities Department of Energy Announces $24 Million for Research on Quantum Networks Learn More about Department of Energy Announces $24 Million for Research on Quantum Networks Department of Energy Announces $16 Million for Research on Scientific Machine Learning for Complex Systems Learn More about Department of Energy Announces $16 Million for Research on Scientific Machine Learning for Complex Systems https://science.
osti. gov/ascr/Research/Applied-Mathematics Applied Mathematics Research The applied mathematics research program develops the key mathematical advances, algorithms, and software for using high-performance scientific computing to solve real-world problems. https://science.
osti. gov/ascr/Research/Computer-Science Computer Science Research The computer science research program supports research to enable computing and networking at extreme scales and generate innovative advancements in computer performance. https://science.
osti. gov/ascr/Research/Partnerships Computational Partnerships Our partnership program supports deep collaborations between discipline scientists, applied mathematicians and computer scientists to accelerate scientific computing. https://science.
osti. gov/ascr/Research/Advanced-Computing-Technology Computer technology is a rapidly advancing field. Emerging technologies are supported through the Research and Evaluation Prototypes program and addresses the challenges of next-generation technologies.
https://science. osti. gov/ascr/Facilities/User-Facilities Supercomputing and Network Facilities Open to researchers from industry, academia, and the national laboratories, ASCR supercomputers are among the fastest in the world and our network is specifically engineered to quickly moving large scientific data.
Funding Opportunity Announcements Learn More about Funding Opportunity Announcements Accessing ASCR Facilities Learn More about Accessing ASCR Facilities ASCR Leadership Computing Challenge (ALCC) Learn More about ASCR Leadership Computing Challenge (ALCC) Learn More about ASCR Workshop Reports Learn More about Benefits of ASCR Advanced Scientific Computing Research U.S. Department of Energy 1000 Independence Avenue. , SW E: sc.
ascr@science. doe. gov
According to the current listing, eligibility includes: All types of applicants are eligible, except FFRDC contractors and 501(c)(4) nonprofit organizations engaged in lobbying activities after December 31, 1995. Confirm the full requirements in the official notice before applying.
DOE Artificial Intelligence (AI) Program / Advanced Scientific Computing Research (ASCR) is funded by U.S. Department of Energy (DOE) Office of Science. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NVIDIA Graduate Fellowship Program is a grant from NVIDIA providing up to $60,000 per award to PhD students conducting research that advances accelerated computing and its applications. Now in its 25th year, the program invites nominations from doctoral students pushing the boundaries of artificial intelligence, robotics, autonomous vehicles, and related fields. Recipients receive not only research funding but also access to NVIDIA technology, products, and engineering expertise, along with a mandatory in-person summer internship. Students are nominated by their faculty advisors and selected based on academic achievement and research area alignment.
Nebius Research Grants Program is sponsored by Nebius. The Nebius research grants program provides researchers with free access to GPU cloud, AI models, and Tavily's agentic search engine, along with Nebius' expertise to accelerate discovery and deployment in AI. It supports academic or scientific projects with clear objectives, innovative use of GPUs for AI, machine learning, data analytics or HPC, and demonstrated feasibility and potential impact.
The Trump administration committed $5B and 278 projects across 15+ agencies to the Genesis Mission. Here's the structure — and how to position for the next wave.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleDOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
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