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The DOE Genesis Mission is a $320+ million Department of Energy initiative that leverages artificial intelligence to advance U.S. energy dominance, strengthen national security, and accelerate scientific discovery.
The funding portfolio supports four pillars: the American Science Cloud, which hosts and distributes AI models and AI-ready scientific data sets; the Transformational AI Models Consortium, which develops self-improving foundation AI models for scientific discovery; 14 projects in robotics, automated laboratories, and autonomous control of large-scale experiments that aim to transform laboratory environments using embodied AI, advanced automation, and robotics; and 37 foundational AI projects focused on organizing scientific data and developing rigorously tested AI models.
The Mission is led by Under Secretary for Science and Innovation Dario Gil and runs across DOE's national laboratory complex.
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Or search similar grants →According to the current listing, eligibility includes: National laboratories under the DOE complex, universities, research institutions, and industry partners participating in DOE Office of Science programs. Specific awards are made through DOE national lab consortia and competitive Office of Science solicitations tied to the Genesis Mission. Public-good outputs include open AI-ready scientific data sets and open foundation models. Confirm the full requirements in the official notice before applying.
The current listing shows more than $320,000,000 allocated by DOE across the Genesis Mission portfolio, distributed across the American Science Cloud, the Transformational AI Models Consortium, 14 projects in robotics, automated laboratories and autonomous experiment control, and 37 foundational AI projects organizing scientific data and developing tested AI models. Individual project award sizes vary by sub-component. Verify award ceilings, matching requirements, and allowable costs in the official notice.
DOE Genesis Mission $320 Million AI Initiative for Energy Dominance Scientific Discovery and Autonomous Laboratories is funded by U.S. Department of Energy (DOE) Office of the Under Secretary for Science and Innovation. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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Read articleThe Trump administration committed $5B and 278 projects across 15+ agencies to the Genesis Mission. Here's the structure — and how to position for the next wave.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
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