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The DOE Genesis Mission is a $320 million initiative to build AI foundation models for American science, distributed across four components: the American Science Cloud (AmSC) for hosting AI models and datasets, the Transformational AI Models Consortium (ModCon) for self-improving scientific AI models, Robotics and Automation for intelligent laboratory systems, and Foundational AI Awards for data curation and model validation.
The FY2024 award round was $20 million across 37 foundational projects and 14 robotics projects, with the most recent allocation directing $68 million toward AI foundation models. The next round is expected later in FY2026. Multi-institution proposals with strong national laboratory partnerships dominated the first round.
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Or search similar grants →According to the current listing, eligibility includes: National laboratory researchers (primary pathway), university researchers as collaborators on lab-led teams, and small businesses through separate DOE Office of Science SBIR programs. Multi-institution proposals with lab partnerships are strongly favored. Confirm the full requirements in the official notice before applying.
The current listing shows $320 million total initiative with $68 million directed toward AI foundation models. Individual project awards typically $500,000 to $5,000,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
DOE Genesis Mission AI Foundation Models for Scientific Discovery is funded by Department of Energy Office of Science. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Violence Against Women Discretionary Grants for Indian Tribal Governments is sponsored by Department of Justice. To increase tribal capacity to respond to violent crimes against Indian women, and to develop and strengthen victim services in cases involving violent crimes against Indian women. This listing is currently active. Program number: 16.587. Last updated on 2024-11-26.
The NSF CISE Future Computing Research (Future CoRe) program supports research in computing and communication foundations, intelligent systems, and network systems. The program funds innovative research that advances the frontiers of computing including artificial intelligence, machine learning, computer vision, natural language processing, and robotics. This is one of NSF's largest computing research programs with $280 million in total budget. Projects can address fundamental computing challenges, novel AI architectures, scalable intelligent systems, and next-generation network infrastructure.
The Trump administration committed $5B and 278 projects across 15+ agencies to the Genesis Mission. Here's the structure — and how to position for the next wave.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleDOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
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