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FY26 Phase I Genesis Mission Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization. This SBIR/STTR Phase I opportunity supports DOE's Genesis Mission, focusing on transforming advances in AI, quantum information science, biotechnology, and advanced materials into breakthroughs.
The initial release targets four AI-driven topic areas: Scaling the Biotechnology Revolution, Realizing Quantum Systems for Discovery: AI for Quantum Computing and Networking, Designing Materials with Predictable Functionality, and Achieving AI-Driven Autonomous Laboratories. This program requires a short Pitch application first.
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GRANTS The Genesis Mission: Tra...
| U.S. DOE Office of Science(SC) The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026).
Genesis Mission: Informational Webinars The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026). Genesis Mission: Informational Webinars U.S. Department of Energy SC-43/Germantown Building 1000 Independence Ave. , SW sc.
grantsandcontracts@science. doe. gov Leaving Office of Science The link you have requested will take you to a website outside the Office of Science.
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According to the current listing, eligibility includes: For-profit U.S. small businesses that meet Small Business Administration eligibility requirements. Confirm the full requirements in the official notice before applying.
The current listing shows anticipated 40 awards totaling $10,000,000 (Phase I). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for FY26 Phase I Genesis Mission Opportunity are due September 10, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
FY26 Phase I Genesis Mission Opportunity is funded by U.S. Department of Energy (DOE) Office of Technology Commercialization. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
NIH SBIR/STTR Phase I award opportunity supporting the Genesis Mission is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This program invites American small businesses to develop breakthrough technologies that advance the U. S. Department of Energy's Genesis Mission, focusing on areas like biotechnology, quantum information science, advanced materials, and AI-driven autonomous laboratories.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (FY26 Phase I Genesis Mission Opportunity) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This funding opportunity invites American small businesses to develop breakthrough technologies that advance the U.S. Department of Energy's Genesis Mission, which aims to accelerate scientific discovery and unlock breakthroughs in AI, quantum information science, biotechnology, and advanced materials. The focus areas include 'Realizing Quantum Systems for Discovery: AI for Quantum Computing and Networking' and 'Achieving AI-Driven Autonomous Laboratories', which could encompass AI for modular energy systems and microgrids.
NVIDIA Graduate Fellowship Program is a grant from NVIDIA providing up to $60,000 per award to PhD students conducting research that advances accelerated computing and its applications. Now in its 25th year, the program invites nominations from doctoral students pushing the boundaries of artificial intelligence, robotics, autonomous vehicles, and related fields. Recipients receive not only research funding but also access to NVIDIA technology, products, and engineering expertise, along with a mandatory in-person summer internship. Students are nominated by their faculty advisors and selected based on academic achievement and research area alignment.
CalSEED Concept Award is a grant from the California Energy Commission that provides $150,000 in funding to early-stage clean energy innovators in California. The program targets individuals, businesses, and nonprofits developing hardware, software, or integrated solutions at Technology Readiness Levels 2-4. Eligible technology areas rotate each cycle and have included battery recycling and reuse, long-duration energy storage, medium- and heavy-duty vehicle electrification, industrial electrification, and advanced EV charging. Applicants must be located in California, have under $1 million in private funding, and propose innovations that benefit California ratepayers. Concept Award winners also receive professional development resources and access to accelerator programs, and may compete for a subsequent $450,000 Prototype Award.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
Read articleOn July 22, 2026 the White House announced more than $5 billion and 15-plus federal agencies behind the Genesis Mission — a national effort to point AI at the hardest problems in science. Here is what the mission actually funds, how its five National Science and Technology Challenges map to real solicitations already opening, and how a research team or small business should position for the money flowing out of it.
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