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FY26 Phase I Genesis Mission Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). The DOE SBIR/STTR Phase I Genesis Mission opportunity invites American small businesses to develop breakthrough technologies that advance the Genesis Mission. This includes projects applying AI in biotechnology, quantum computing, advanced materials, and autonomous laboratories.
This initial release precedes a broader Phase I funding opportunity expected later in Fall 2026.
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Energy Department Announces $293 Million in Funding to Support Genesis Mission National Science and Technology Challenges | Department of Energy Energy Department Announces $293 Million in Funding to Support Genesis Mission National Science and Technology Challenges The U.S. Department of Energy today announced funding to advance the Genesis Mission’s efforts to tackle the nation’s most complex science and technology challenges.
WASHINGTON— The U.S. Department of Energy (DOE) today announced funding to advance the Genesis Mission’s efforts to tackle the nation’s most complex science and technology challenges. This includes a $293 million Request for Application (RFA),“The Genesis Mission: Transforming Science and Energy with AI.
” Through this RFA, DOE invites interdisciplinary teams to leverage novel AI models and frameworks to address over 20 national challenges spanning advanced manufacturing, biotechnology, critical materials, nuclear energy, and quantum information science.
“The Genesis Mission has caught the imagination of our scientific and engineering communities to tackle national challenges in the age of AI,” said Under Secretary for Science Darío Gil and Genesis Mission Director. “With these investments we seek breakthrough ideas and novel collaborations leveraging the scientific prowess of our National Laboratories, the private sector, universities, and science philanthropies.
” The RFA is open to interdisciplinary teams from DOE National Laboratories, U.S. industry, and academia. Phase I awards will range from $500,000 to $750,000 and will support a nine month project period. Phase II awards will range from $6 million to $15 million over a three year project period.
Teams may apply directly to either phase in FY 2026, and successful Phase I teams will be eligible to compete for larger Phase II awards in future cycles. Phase I applications and Phase II letters of intent are due April 28, 2026. Phase II applications are due May 19, 2026.
DOE plans to hold an informational webinar about this RFA on March 26, 2026. For full eligibility, application instructions, and challenge details, see the official NOFO: DE-FOA-0003612 . Registration instructions and other details will be posted here .
NNSA Achieves Milestone in Uranium Purification at Y-12 NSC View Previous Press Release Trump Administration Keeps Coal Plant Open to Ensure Affordable, Reliable and Secure Power in the Northwest Explore more on these topics: (202) 586-4940 or DOENews@hq. doe. gov
According to the current listing, eligibility includes: American small businesses. Information to determine eligibility for SBIR and STTR can be found online. Confirm the full requirements in the official notice before applying.
The current listing shows up to $250,000 (Phase I); likely $1.5 million (Phase II). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for FY26 Phase I Genesis Mission Opportunity are due September 10, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
FY26 Phase I Genesis Mission Opportunity is funded by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
Small Business Innovation Research (SBIR) Program (FY26 Phase I Genesis Mission SBIR/STTR opportunity) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I funding opportunity encourages American small businesses to develop breakthrough technologies aligned with DOE's Genesis Mission across four topic areas: biotechnology, quantum computing and networking, advanced materials, and AI-driven autonomous laboratories.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs - FY26 Phase I Genesis Mission Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). The DOE SBIR/STTR programs offer competitive non-dilutive funding to small businesses developing innovative technologies with strong commercial potential. This specific Phase I opportunity focuses on the Genesis Mission, which aims to unleash AI-accelerated innovation and discovery across various fields, including advanced materials and potentially microelectronics. The initial release supports projects in areas such as 'Achieving AI-Driven Autonomous Laboratories', which could encompass AI in microelectronics.
NVIDIA Graduate Fellowship Program is a grant from NVIDIA providing up to $60,000 per award to PhD students conducting research that advances accelerated computing and its applications. Now in its 25th year, the program invites nominations from doctoral students pushing the boundaries of artificial intelligence, robotics, autonomous vehicles, and related fields. Recipients receive not only research funding but also access to NVIDIA technology, products, and engineering expertise, along with a mandatory in-person summer internship. Students are nominated by their faculty advisors and selected based on academic achievement and research area alignment.
CalSEED Concept Award is a grant from the California Energy Commission that provides $150,000 in funding to early-stage clean energy innovators in California. The program targets individuals, businesses, and nonprofits developing hardware, software, or integrated solutions at Technology Readiness Levels 2-4. Eligible technology areas rotate each cycle and have included battery recycling and reuse, long-duration energy storage, medium- and heavy-duty vehicle electrification, industrial electrification, and advanced EV charging. Applicants must be located in California, have under $1 million in private funding, and propose innovations that benefit California ratepayers. Concept Award winners also receive professional development resources and access to accelerator programs, and may compete for a subsequent $450,000 Prototype Award.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
Read articleOn July 22, 2026 the White House announced more than $5 billion and 15-plus federal agencies behind the Genesis Mission — a national effort to point AI at the hardest problems in science. Here is what the mission actually funds, how its five National Science and Technology Challenges map to real solicitations already opening, and how a research team or small business should position for the money flowing out of it.
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