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FY26 Phase I Genesis Mission SBIR/STTR opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization. This SBIR/STTR opportunity targets AI-driven topic areas, including biotechnology, quantum computing, materials design, and autonomous laboratories, to support DOE's Genesis Mission.
It seeks to accelerate scientific discovery and unlock breakthroughs in AI, quantum information science, biotechnology, and advanced materials that strengthen U.S. scientific and technological leadership.
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Or search similar grants →According to the current listing, eligibility includes: For-profit U.S. small businesses that meet Small Business Administration eligibility requirements. Unlike a standard SBIR proposal, this program requires a short Pitch application first; only companies invited after Pitch review can submit a full application. Confirm the full requirements in the official notice before applying.
The current listing shows approximately 40 awards totaling $10,000,000 in Phase I, representing up to $44,000,000 in cumulative funding across the projects' full lifecycles. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was September 10, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
FY26 Phase I Genesis Mission SBIR/STTR opportunity is funded by U.S. Department of Energy (DOE) Office of Technology Commercialization. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
Small Business Innovation Research (SBIR) Program Phase I (DOE Genesis Mission) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This DOE SBIR Phase I opportunity focuses on the Genesis Mission, supporting breakthrough technologies in areas including "Scaling the Biotechnology Revolution." Projects related to Pichia pastoris, particularly in areas of biotechnology for energy production, biomaterials, or sustainable processes, would be relevant. This is a pitch-first application process.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (Genesis Mission Phase I) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I opportunity, focused on DOE's Genesis Mission, supports technologies in four areas including "Scaling the Biotechnology Revolution." Pichia pastoris is a significant host for biotechnology, particularly in the production of enzymes, biopharmaceuticals, and other biomolecules. Proposals advancing biotechnology, especially those with strong commercial potential and alignment with DOE mission areas, would be relevant.
On July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleOn August 24, 2026, DOE and SBA signed a memorandum of agreement creating the Small Business Investment Company-Energy Initiative, pointing a $58 billion SBA-leveraged investment program at DOE's technology priorities. No application, no NOFO, no deadline. Here is how SBIC capital actually works, why a January 2026 rule change made this possible, and what a company sitting on a DOE Phase II award should do about it.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
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