Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42, R43/R44 Clinical Trial Optional)

PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) is sponsored by National Institute on Drug Abuse (NIDA) / National Institutes of Health (NIH). NIDA participates in this omnibus solicitation which targets PI-initiated research with potential for technology commercialization and impact on public health in the area of substance use disorders. This program supports small businesses to develop technologies that can advance NIDA's mission, including basic neuroscience, translational and clinical research, clinical diagnosis and treatment, and dissemination and implementation of evidence-based research on mental disorders.

PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) is sponsored by National Institute on Drug Abuse (NIDA) / National Institutes of Health (NIH). NIDA offers funding through this STTR program to support small businesses in developing innovative technologies with commercial potential or significant societal benefits related to substance use disorders and mental health. This includes basic neuroscience research, translational and clinical research, clinical diagnosis and treatment, and dissemination and implementation of evidence-based research on mental disorders.

1. Project Background, Goals, and Objectives The Public Diplomacy Section invites proposals for programs that support one of the following U.S. Embassy priority program areas listed below. Applicants are strongly encouraged to propose collaborative approaches and programs that integrate multiple priority areas. Priority Program Areas/Goals: Applicants may submit a proposal to address one of the program goals below. Proposals should focus on one or more of the priority outcomes, but applicants may also recommend their own objective. Priority Program Areas: · Commercial Diplomacy and U.S.-Zimbabwe Trade · Artificial Intelligence for improved prosperity · Cybersecurity · Technology Literacy and Resilience · Free Speech · American Excellence in education, media, sports, creative industries, civil society GOAL 1. FREE SPEECH AND OPEN EXPRESSION Promote democratic principles including freedom of speech and civic participation; particularly if they share best practices for citizen advocacy or explore the challenges modern media houses face in a digital economy and the ethical standards needed to gain public confidence. Project Audience(s): Organizations and individuals that reflect American values, policies and priorities Priority Outcomes(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address the priority program areas. Outcome: A more informed and media-literate Zimbabwean public that can identify and resist disinformation, with stronger independent media institutions operating transparently and ethically. Strengthening independent media in Zimbabwe advances U.S. strategic interests in promoting open, stable societies across Africa. GOAL 2. ADVANCE U.S.- ZIMBABWE COMMERCIAL TIES AND ECONOMIC PROSPERITY Advance economic prosperity; particularly connecting social entrepreneurs and the creative community with online marketing tools. Project Audience(s): Organizations and individuals that reflect American values, policies, and priorities Priority Outcomes(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address the priority program areas. Outcome: Increased bilateral trade activity, expanded market access for U.S. goods and services, and a growing cohort of Zimbabwean entrepreneurs with direct ties to U.S. businesses and platforms. Deepening commercial relationships with Zimbabwe creates new markets for American exports, strengthens U.S. economic influence in the region, and reduces Zimbabwe's economic dependence on adversarial partners. This directly supports the America First economic agenda and commercial diplomacy priorities. GOAL 3. HARNESS EMERGING TECHNOLOGY AND ARTIFICIAL INTELLIGENCE FOR DEVELOPMENT Empower Zimbabweans to leverage American innovations in technology, AI, and digital tools, to drive economic growth, improve livelihoods, and improve digital trade opportunities between the United States and Zimbabwe. Project Audience(s): Organizations and individuals that reflect American values, policies, and priorities. Priority Outcomes(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address the priority program areas. Outcome: A growing base of Zimbabwean professionals and institutions equipped to adopt, adapt, and deploy emerging American technologies - including AI - for economic and social development, using U.S.-developed platforms and frameworks. Promoting U.S.-developed technology standards and platforms in Zimbabwe expands American technological influence and market share, and builds a digital ecosystem aligned with U.S. values of openness, security, and innovation. GOAL 4. EXPAND U.S.-ZIMBABWE PROFESSIONAL NETWORKS AND PEOPLE-TO-PEOPLE TIES Deepen bilateral relationships through targeted workshops, alumni engagement, and exchange partnerships that advance shared solutions and reinforce American values and influence. Project Audience(s): Organizations and individuals that reflect American values, policies, and priorities. Priority Outcomes(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address the priority program areas. Outcome: Strengthened alumni networks and new professional cohorts with sustained engagement with U.S. counterparts, resulting in collaborative projects, cross-sector partnerships, and ongoing people-to-people dialogue. Strong professional networks create durable channels of U.S. influence and goodwill in Zimbabwe. Alumni of U.S. exchange programs consistently demonstrate greater alignment with U.S. foreign policy interests and serve as credible advocates for American businesses, institutions, and values within their professional and social communities. Funding Opportunity Number: AF-HAR-FY26-03. Assistance Listing: 19.040. Funding Instrument: CA. Category: O. Award Amount: $10K – $15K per award.

AI integration in CCSI work practice: catalysing innovation and competitiveness is sponsored by European Commission — Horizon Europe. Expected Outcome: Projects should contribute to all of the following expected outcomes: Insights, recommendations, strategies, guidelines, methods and tools supporting full AI integration in CCSI practices become available to CCSI, policymakers, and stakeholders. Scenarios for co-created solutions tailored to CCSI needs, utilizing quality data and federated data sources, along with digital infrastructures, and inclusive cooperation processes, become available. Generally made available AI-powered and ethically designed solutions, tools and services in several CCSI areas benefit creators, cultural professionals, and society, including persons with disabilities and other specific needs, fostering innovative creative expressions and improving creative business models while preserving and enhancing cultural diversity, and inclusion. By mastering ethical and inclusive AI, CCSI are empowered drivers of culture, innovation, competitiveness and societal wellbeing. Scope: AI technologies are transformative, providing unprecedented opportunities for human creativity, experimentations and co-creations. AI profoundly impacts cultural and creative sectors and industries, changing practices, facilitating new ways of working and making innovative services and products possible. Artists, industry players, and cultural organisations increasingly use AI, for assistance in content creation, production, and management, to predict trends, personalise market content, engage audiences, enhance cultural heritage preservation and accessibility, and many more purposes. Cultural and creative sectors and industries (CCSI) [1] need to fully harness AI's potential to maintain relevance, expand their impact and value, increase competitiveness, and keep their vibrant, inclusive nature. Embracing and co-creating ethical AI solutions tailored to CCSI needs will, among other benefits, enable the automation of low-creativity tasks, allowing to increase focus on high-value activities that enhance creativity and productivity, thus unlocking unprecedented possibilities. Production times and costs can be reduced, market reach expanded, preservation, interpretation and inclusive access to cultural heritage enhanced, and new job categories could emerge. Although several initiatives are on the ground, a comprehensive understanding of enabling frameworks and factors and of what is still lacking in terms of data, standards, infrastructures, computing power, tools, knowledge and capacity for the CCSI to fully embrace the opportunities opened by AI is essential for effectively integrating AI technologies into CCSI practices and workflows. Proposals should assess the current level of AI readiness in the CCSI, investigate the specific barriers to AI adoption in the sectors, and highlight areas where AI can offer the most benefits. In continuous engagement with the sectors, based on the analysis of current practices and through concrete use cases, proposals should produce strategic guidance to extensively and seamlessly integrate AI into CCSI operations, enhancing efficiencies, averting risks, and facilitating cross-sector collaboration. Based on this analysis, they should develop a set of tailored tools designed to address the specific gaps and leverage the opportunities uncovered during the assessment. These tools should be strategically aligned with the sector's needs, ensuring they provide targeted solutions to enhance AI adoption and maximize its potential benefits. They should be scalable, affordable for smaller, less-resourced CCSI actors and accompanied by related documentation and training materials and documentation. Proposals should address one of the following two options, and are allowed to address both: Develop scalable pilots for innovative AI-enabled products and services across diverse segments of sectoral value chains, in cooperation with CCSI. These pilots are expected to address identified gaps in CCSI operations and prioritise solutions that catalyse innov Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Culture, creativity and inclusive society, Cultural Heritage Keywords: Artificial intelligence, intelligent systems, multi agent systems, Business models, Capacity building, Creativity management, Cultural heritage, cultural memory, Data and image processing, Digitalisation/ICT and cultural heritage, Entrepreneurship, Experimentally-driven research and innovation, High performance computing, Intangible cultural heritage, Knowledge transfer, Machine learning, statistical data processing and applications using signal processing (e.g. speech, image, video), Open innovation, Public administration, Social innovation, Tangible cultural heritage, Trustworthy ICT, Visual arts, performing arts, design, AI adoption, AI integration, CCSI, accessibility, audience engagement, automation, business models, capacity building, co-creation, content creation, creative industries, creative innovation, creators’ rights, cross-sector collaboration, cultural and creative sectors, cultural diversity, cultural inclusion., data-driven creativity, digital infrastructures, digital transformation, emerging jobs, ethical AI, federated data, heritage preservation, inclusive AI, innovation ecosystem, knowledge transfer, market reach, multilingual access, personalization, sustainable creative economy, sustainable models, underserved audiences, upskilling

Biological Technologies Broad Agency Announcement (HR001126S0003) is sponsored by Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO). DARPA BTO is soliciting proposals that leverage biological properties and processes to revolutionize the ability to protect the nation's warfighters. This includes harnessing advances in artificial intelligence (AI) and machine learning (ML) to create new opportunities for transformative science across the biological spectrum. Specific interests include discovering interventions that utilize biotechnology, biochemistry, molecular biology, microbiology, neuroscience, psychology, cognitive science, social and behavioral science, and related disciplines to assess and optimize human performance and teaming.