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Find similar grantsHealth Systems Implementation Initiative (HSII) Implementation Projects - Hypertension is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI's HSII funds health systems to implement evidence-based approaches for addressing hypertension, including team-based care and home blood pressure monitoring.
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* **Letter of Intent (LOI) Deadline** April 28, 2026; 5 pm (ET) * **LOI Status Notification** * **Application Deadline** The intent of this Call for Proposals (CFP) for Health Systems Implementation Initiative (HSII) Implementation Projects is to provide an opportunity for HSII Participants to propose projects that promote the uptake of specific evidence from PCORI-funded patient-centered comparative clinical effectiveness research within their healthcare delivery settings.
Each HSII Participant may propose one project in response to this CFP. Applicants will have the opportunity to propose one of two project types: 1. **HSII Implementation Projects.
** These projects will have the goal of broadly integrating evidence into care delivery within the health system’s settings. HSII Implementation Projects should accomplish the desired practice change in ways that are sustainable within the HSII Participant delivery setting and scalable within their system, as relevant.
Projects will include rigorous program evaluation that documents the execution of implementation activities, as well as the impact on health and healthcare outcomes. 2. **HSII Pilot Projects.
** These projects will have the goal of developing and/or refining a proposed implementation approach — i.e., a bundle of implementation strategies — and then piloting the use of the approach by integrating use of the evidence on a small scale.
Project evaluation will be designed to demonstrate the feasibility and readiness of that approach, paving the way for a broader effort within the health system once the HSII Pilot Project is complete. The following topics will be offered in the CFP.
* Topic 5: Telepsychiatry Collaborative Care for Complex Psychiatric Disorders * Topic 6: Family-Based Behavioral Treatment for Healthy Child Weight This CFP will no longer offer the **Antibiotics, Weight Loss, Hypertension** or **ePROs** topics that were included in the previous CFPs for HSII Implementation Projects.
For HSII Implementation Projects, **maximum project budgets** that applicants may request will vary based on project type, the evidence topic selected as the focus for implementation and project scale in terms of the number of participating care delivery sites. The maximum project budgets in the table below are total costs.
**Number of Participating Care Delivery Sites****Topic 5: Telepsychiatry Collaborative Care for Complex Psychiatric Disorders** 100-150 Up to $1. 5 million **Number of Participating Primary Care Delivery Sites****Topic 6: Family-Based Behavioral Treatment for Healthy Child Weight** 100-150 Up to $1. 5 million For **HSII Pilot Projects**, maximum project budgets are $200,000 total costs.
* For **HSII Implementation Projects:** Up to 48 months (four years). Project timelines should be structured to include these phases: * **Pre-Implementation**(up to 12 months): Preparation for implementation. * **Active Implementation Phase** (at least 12 months and up to 24 months for all participating care delivery sites): Delivery of the intervention/program as part of standard care with implementation support.
* **Maintenance Phase** (at least six months for all participating care delivery sites): Continued delivery of the intervention/program with reduced or no implementation support. * **Final Reporting and Project Close-Out**: Final evaluation activities (e.g., data collection, analysis) and preparation of the final report. * For **HSII Pilot Projects:**At least six months and up to 24 months.
Project timelines should account for when the implementation approach will be finalized, when the pilot will launch and when data collection and analysis activities will be completed.
* Eligible HSII Participant Organizations: Health systems that are participating in the Health Systems Implementation Initiative (i.e., that have a fully executed HSII Master Funding Agreement (MFA) with PCORI for HSII) are eligible to submit a proposal in response to this CFP.
* Eligible principal investigators: The principal investigator must be an MFA project lead designated in the MFA entered into by the HSII Participant Organization. If proposing a dual-principal investigator structure, at least one principal investigator must be an MFA project lead designated in the MFA; the other can be another leader, or a second MFA project lead if there are two MFA project leads designated in the MFA.
HSII Participants are encouraged to refer to the HSII FAQs web page for further information and any updates. Download Full Announcement
According to the current listing, eligibility includes: Health systems and institutions that are HSII Participants. Universities that are part of health systems would be eligible. Confirm the full requirements in the official notice before applying.
Health Systems Implementation Initiative (HSII) Implementation Projects - Hypertension is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
PCORI launched five simultaneous research funding tracks with $120 million in direct costs for pragmatic studies. Why this non-NIH funder deserves a place in your grant strategy.
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