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Find similar grantsMaternal Mortality and Morbidity Research is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI seeks to fund high-quality comparative clinical effectiveness research projects focusing on maternal morbidity and mortality.
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* PCORI's Research Funding Process * What You Need to Know to Apply ### Applicant and Awardee Resources * Research & Related Projects #### Research & Related Projects * CER Results On the Path to Impact * PCORI in the Literature #### Engagement in Research * Foundational Expectations for Partnerships in Research * Foundational Expectations for Partnerships * Background on the Foundational Expectations * Benefits of Engagement in Research * Real-World Examples by Foundational Expectation * Frequently Asked Questions * Why Patient Engagement in Research Matters * The Science of Engagement in Research * Tools and Resources To Support Engagement in Research * Engagement in Health Research Literature Explorer * Engagement Award Program * Get Involved: Participate in the Research Process * Implementation of Evidence #### Implementation of Evidence * Putting Evidence to Work * Evidence Synthesis Reports and Interactive Visualizations * Emerging Topics: Reports and Horizon Scans * Intellectual and Developmental Disabilities * Maternal Morbidity and Mortality * 2026 PCORI Annual Meeting * Financial Statements and Reports * Governing & Operations Documents * Monitoring and Evaluating Progress * Advisory Panel Openings * Application Review and Selection Process * Procurement Opportunities * PCORI's Research Funding Process * What You Need to Know to Apply * Research & Related Projects Toggle Menu * CER Results On the Path to Impact * PCORI in the Literature * Engagement in ResearchToggle Menu * Foundational Expectations for Partnerships in ResearchToggle Menu * Foundational Expectations for Partnerships * Background on the Foundational Expectations * Benefits of Engagement in Research * Real-World Examples by Foundational Expectation * Frequently Asked Questions * Why Patient Engagement in Research Matters * The Science of Engagement in Research * Tools and Resources To Support Engagement in Research * Engagement in Health Research Literature Explorer * Engagement Award Program * Get Involved: Participate in the Research Process * Implementation of Evidence Toggle Menu * Putting Evidence to Work * Evidence Synthesis Reports and Interactive Visualizations * Emerging Topics: Reports and Horizon Scans * Health TopicsToggle Menu * Intellectual and Developmental Disabilities * Maternal Morbidity and Mortality * News & Events Toggle Menu * 2026 PCORI Annual Meeting * Financial Statements and Reports * Governing & Operations Documents * Monitoring and Evaluating Progress * PCORI Advisory PanelsToggle Menu * Advisory Panel Openings * Application Review and Selection Process * Procurement Opportunities 3.
Maternal Morbidity and Mortality (MMM) # Maternal Morbidity and Mortality (MMM) PCORI funds comparative clinical effectiveness research (CER) and related projects related to maternal health to fill evidence gaps and provide information so patients, caregivers, clinicians and other decision makers can make informed decisions about their health and health care.
View PCORI's MMM Portfolio ## Study Results that Support Informed Decisions ### Testing the Effectiveness of Adding Group Therapy to Home Visiting Services on Reducing Postpartum Depression in Women with Low Incomes: A Randomized Controlled Trial Adding a group therapy program called Mothers and Babies to home visiting services did not reduce depressive symptoms in perinatal women more than home visiting services alone, according to this PCORI-funded research study.
However, group therapy led by a community health worker was comparably effective as group therapy led by a mental health professional in reducing depressive symptoms. The study included 824 perinatal women enrolled in 37 home visiting programs in seven midwestern states. The trial results were published in the _Archives of Women’s Mental Health_ in March 2021.
### Can an Online Program Help Women with a History of Preeclampsia Reduce Their Risk of Heart Disease?
A Randomized Controlled Trial Health 4 Moms, an online intervention designed for and by women with a history of preeclampsia to improve healthy lifestyle choices improved patients’ knowledge of heart disease risk, self-efficacy to achieve a healthy diet, and reduced physical inactivity among women with recent preeclampsia, according to this PCORI-funded research study. The study enrolled 151 mothers nationwide with recent preeclampsia.
The trial results were published in the _Journal of Women's Health_ in July 2019. ## Studies and Projects Spotlights ### Comparing Methods for Treating Depression and Anxiety among Pregnant and Postpartum Women Talk therapy is effective for treating depression and anxiety, and women often prefer it over medication.
The **research study** team is comparing the effectiveness of behavioral activation (BA), a form of talk therapy, provided by a mental health professional versus a nurse or midwife, in addition to the comparison of in-person BA with BA given through telemedicine, or by videoconference.
### Engaging Stakeholders in Perinatal Depression Research in the Context of COVID-19 Depression can be a major pregnancy complication that can cause adverse outcomes for both mothers and their infants if left untreated. This **engagement project** will explore ways to engage participants in patient-centered and clinical effectiveness research and build the capacity to engage stakeholders in the research process.
### Bridging the Chasm between Pregnancy and Women’s Health over the Life Course Women with gestational diabetes (GDM) and other pregnancy complications have a high risk for chronic illnesses in later life. This **engagement project** uses GDM as a case in point to galvanize diverse stakeholders to build systems-based bridges addressing the fragmentation in women’s health care.
## PCORI Systematic Reviews PCORI has commissioned several reviews with the goal to produce up-to-date, actionable evidence to inform important healthcare choices.
### Impact of Doula Support During Pregnancy, Childbirth and Beyond ### Peripartum and Postpartum Management of Women with Hypertensive Disorders of Pregnancy ### Postpartum Care for Women up to One Year After Birth ### Telehealth Strategies for the Delivery of Maternal Health Care PCORI commissioned a rapid review to assess evidence on the effectiveness of telehealth strategies for the delivery of maternal healthcare.
Because telemedicine has experienced a swift and widespread adoption in the United States, PCORI sought to understand the evidence base on a compressed timeline in order to inform our future research investments. The evidence synthesized in this rapid review indicates that telehealth for maternal health care delivery is a promising alternative and/or supplement to usual, in-person care.
Equally important are the evidence gaps identified in this review that point us to future research priorities. Full results of this rapid review are also available in the _Annals of Internal Medicine_. View Rapid Review ReportRead Related Blog ## Additional Studies and Projects View a selection of additional PCORI-funded research studies and Engagement projects that focus on maternal morbidity and mortality.
View PCORI's MMM Portfolio ### California's Refugee Reproductive Health Network (ReproNet): Engaging Refugee Women in Research Partnerships ### Comparing Two Ways To Provide Mental Health Treatment During and After Pregnancy ### Exploring Ways To Reduce Depressive Symptoms During Pregnancy ### Charting the Course for Patient-Centered Research to Address Inequities in Perinatal Mental Health & Maternal Mortality 1333 New Hampshire Avenue NW, Suite 1200 Phone: (202) 827-7700 | Fax: (202) 355-9558 * Frequently Asked Questions * Trademark Usage Guidance
According to the current listing, eligibility includes: Researchers and organizations capable of conducting comparative clinical effectiveness research. Confirm the full requirements in the official notice before applying.
Maternal Mortality and Morbidity Research is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
PCORI launched five simultaneous research funding tracks with $120 million in direct costs for pragmatic studies. Why this non-NIH funder deserves a place in your grant strategy.
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