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The NCI ITCR Early-Stage Development U01 funds the design, prototype, and pilot of novel AI/ML-driven informatics technologies that improve acquisition, management, and/or analysis of data across the cancer research continuum.
Funded projects include foundation models for cancer pathology, multimodal cancer foundation models, AI-driven clinical decision support, deep learning tumor microenvironment analysis, and AI clinical trial matching tools. Awards provide up to $300K direct costs per year for up to 3 years. Strong fit for academic medical centers, cancer centers, and informatics labs building open-source AI cancer tools.
RFA-CA-27-019 reissues the long-running ITCR program through 2027 with multiple receipt dates.
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Or search similar grants →According to the current listing, eligibility includes: U.S. and foreign organizations including higher education institutions, nonprofits, for-profit small businesses, federal and state government agencies, hospitals, and tribal organizations. Multiple PIs permitted. Foreign components allowed. Confirm the full requirements in the official notice before applying.
The current listing shows up to $300,000 direct costs per year for up to 3 years (~$900,000 direct costs total per project); total cost typically ~$1.5M including indirect costs. NCI plans multiple awards per cycle. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for NCI ITCR Early-Stage Development of Informatics Technologies for Cancer Research U01 RFA-CA-27-019 for AI and Machine Learning Cancer Tools are due October 20, 2027. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
NCI ITCR Early-Stage Development of Informatics Technologies for Cancer Research U01 RFA-CA-27-019 for AI and Machine Learning Cancer Tools is funded by National Cancer Institute (NCI) Informatics Technology for Cancer Research (ITCR) Program. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NCI ITCR Sustained Support U24 (RFA-CA-27-021) sustains widely-adopted cancer informatics technologies in production use by the cancer research community. Funds operational support, user experience improvement, security and accessibility hardening, and continued community engagement for mature AI/ML tools. Examples include cBioPortal, AI cancer imaging platforms, genomic data commons tools, and clinical informatics platforms. Up to $600K direct costs per year for up to 5 years. Strong fit for teams maintaining open-source cancer AI infrastructure with broad user communities.
NCI ITCR Advanced Development U24 (RFA-CA-27-020) funds the maturation, enhancement, validation, and dissemination of emerging informatics technologies for cancer research and clinical care. Awards support AI/ML platforms ready to move beyond prototype, including deep learning cancer imaging tools, AI clinical decision support systems, multimodal cancer foundation models, AI-driven genomics pipelines, and digital pathology AI. Up to $600K direct costs per year for up to 5 years allows substantial software engineering, validation, and community adoption activities. Strong fit for established cancer informatics teams with mature AI prototypes ready for production deployment.
On July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission — the government-wide 'AI for science' effort — announcing 278 first projects and 14 National Science and Technology Challenges spanning health, energy, infrastructure, manufacturing, and national security. More than 15 federal agencies are contributing awards, datasets, and facilities. Here is how the pieces fit, why it reorganizes the science-funding map, and how to position for the awards flowing out of it.
Read articleOn July 22, 2026 the White House announced more than $5 billion and 15-plus federal agencies behind the Genesis Mission — a national effort to point AI at the hardest problems in science. Here is what the mission actually funds, how its five National Science and Technology Challenges map to real solicitations already opening, and how a research team or small business should position for the money flowing out of it.
Read articleOn July 22, 2026 the White House committed more than $5 billion to expand the Genesis Mission, DOE announced its first 278 project selections, and 15+ agencies organized their AI-for-science funding around five National Science and Technology Challenges. Here is what the mobilization means for universities, small businesses, and nonprofits — and how to position for the funding that flows from it.
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