NIGMS Biomedical Technology Optimization and Dissemination (BTOD) Centers

The NIGMS Biomedical Technology Optimization and Dissemination (BTOD) Centers program is a grant from the National Institute of General Medical Sciences (NIH NIGMS) that supports the optimization and broad dissemination of late-stage biomedical technologies for use by expert and non-expert researchers alike. Awards provide up to $850,000 in direct costs per year under the RM1 mechanism (NOFO PAR-23-110).

Eligible technologies include analytical biochemistry, chemical biology, computational methods, spectroscopy, microscopy, structural biology, molecular biology, and cell manipulation. Eligible applicants are U.S.-based researchers and institutions whose proposed technology has demonstrated laboratory feasibility; significant technology development work is out of scope.

Applicants must contact NIGMS program directors at least 10 weeks before the submission deadline of January 27, 2026. Funded centers must establish an External Advisory Committee and a community engagement plan.

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Technologies of interest include but are not limited to analytical biochemistry, chemical biology, computational methods, high throughput biochemistry methods, molecular modeling, modeling of biological systems, data science, spectroscopy, microscopy, imaging, structural biology, molecular biology, and cell manipulation.

The BTOD Notice of Funding Opportunity (NOFO), an update of the Biomedical Technology Development and Dissemination (BTDD) program, is PAR-23-110 . Potential applicants are strongly advised to contact NIGMS staff at least 10 weeks prior to the application due date to discuss the suitability of a proposed project for the program.

Projects requiring significant technology development fall outside this program's scope, but may be appropriate for NIGMS Technology Development Program (R21 or R01) . Prospective applicants with mature technologies ready to serve as a user resource may consider applying for the NIGMS National and Regional Resources (R24) or the NIGMS Mature Synchrotron Resources (P30) ​​.

​ RPPR Guidance for Funded Centers Carolina Salvador Morales, Ph. D. ​ and Alvin Yeh, Ph.

D. ​ Division of Biophysics, Biomedical Technology, and Computational Biosciences National Institute of General Medical Sciences National Institutes of Health Center on Macromolecular Dynamics by NMR Spectroscopy (COMD/NMR) New York Structural Biology Center BTDD Grant Number: RM1-GM145397 Principal Investigator: Arthur G. Palmer, Ph.

D. The COMD/NMR Center develops advanced methods in NMR spectroscopy for studying conformation and dynamics of protein and nucleic acid during biological processes and makes these sophisticated methods accessible to a wider research community to facilitate applications to biomedical questions. This Center was previously supported by the BTRR Program (P41GM118302).

Center on Probes for Molecular Mechanotechnology (CPMM) BTDD Grant Number: RM1-GM145394 Principal Investigator: Khalid Salaita, Ph. D. CPMM optimizes and disseminates advanced technologies to measure forces at the surface of cells.

The CPMM team will develop probes for light microscopy, flow cytometry, and plate readers. These probes will enable studies of mechanobiology and mechanotransduction pathways in cells. ​ The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical Research BTDD Grant Number: RM1-GM144227 Principal Investigator: Ryan A.

Mehl, Ph. D. Genetic Code Expansion (GCE) technology – the engineering of cellular translation to express proteins containing non-canonical amino acids – provides unprecedented ways to probe and manipulate macromolecular structure and function, analyze protein malfunctions in disease, engineer bioanalytical tools, and create precision biotherapeutics.

The GCE4All Center's mission is to optimize and extend existing GCE technologies to enable facile use by non-specialists and broadly disseminate them via widespread education, effective training, and sustainable access so that powerful GCE approaches become standard widely-used biomedical research tools.

National Resource for Advanced NMR Technology Florida State University and University of Florida BTDD Grant Number: RM1-GM148766​ Principal Investigators: Robert W. Schurko, Ph. D.

; William W. Brey, Ph. D.

; Joanna R. Long, Ph. D.

The National Resource for Advanced NMR Technology leverages recent breakthroughs in materials science and instrumentation to develop technologies that advance the sensitivity and spectral resolution of biomolecular NMR spectroscopy.

These advances will lead to new tools that are needed to provide novel insights into biological processes and structures that are at the forefront of biomedical research, including enzyme mechanisms, metabolic flux, structure-function relationships, mechanisms of intrinsically disordered proteins, and cell wall structures.

This Resource aims to disseminate their technologies and advances to a broad user community through educational lectures and training activities, peer-reviewed publications and conference presentations, annual workshops, and a dedicated website with Resource materials and postings. This Resource was previously supported by the BTRR Program (P41GM122698).

Native Mass Spectrometry Guided Structural Biology Center (nMS->SB) Georgia Institute of Technology BTDD Grant Number: RM1-GM149374​ Principal Investigator: Vicki Wysocki, Ph. D.

The nMS-> SB Center empowers specialist and non-specialist biomedical researchers to use native MS workflows and instrumentation that permit rapid, accurate, and highly sensitive structural biology characterization of mass, subunit stoichiometry, connectivity and topology, conformational diversity/stability/flexibility, heterogeneity, hierarchy in assembly, and relative subunit binding strengths of macromolecular complexes.

Interdigitation of Center components with other structural biology tools will advance structural biology initiatives worldwide with integrated suites of nMS-based tools translated to users. This Center was previously supported by the BTRR Program (P41GM128577).

​ UTSW-UNC Center for Cell Signaling Analysis UT Southwestern Medical Center and the University of North Carolina Chapel Hill BTDD Grant Number: RM1-GM145399 Principal Investigators: Gaudenz Danuser, Ph. D. ; Kevin M.

Dean, Ph. D. ; K​laus M.

Hahn, Ph. D. The Center for Cell Signaling Analysis optimizes and disseminates advanced technologies for visualization and quantitative analysis of molecular events in living cells and tissues.

User-friendly and integrated technologies of the Center combine biosensors, optogenetics and chemogenetics; modular, high-speed, and high resolution light-sheet microscopes; and image analysis and computational modeling to derive signaling circuits, including the inference of causality and kinetics of connections.

Technologies are disseminated through existing infrastructure including imaging facilities throughout the U.S., the FIJI software ecosystem, and commercial and non-profit companies. This page last updated on HHS Vulnerability Disclosure U.S. Department of Health and Human Services National Institutes of Health: NIH...

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